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SHD Src homology 2 domain containing transforming protein D [ Homo sapiens (human) ]

Gene ID: 56961, updated on 5-Aug-2022

Summary

Official Symbol
SHDprovided by HGNC
Official Full Name
Src homology 2 domain containing transforming protein Dprovided by HGNC
Primary source
HGNC:HGNC:30633
See related
Ensembl:ENSG00000105251 MIM:610481; AllianceGenome:HGNC:30633
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable phosphotyrosine residue binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 6.5), heart (RPKM 2.0) and 5 other tissues See more
Orthologs
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Genomic context

See SHD in Genome Data Viewer
Location:
19p13.3
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (4279069..4290722)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (4262345..4273993)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4279066..4290719)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Epstein-Barr virus induced 3 Neighboring gene YJU2 splicing factor homolog Neighboring gene transmembrane and immunoglobulin domain containing 2 Neighboring gene fibronectin type III and SPRY domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphotyrosine residue binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
SH2 domain-containing adapter protein D
Names
src homology 2 domain-containing transforming protein D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001372011.1NP_001358940.1  SH2 domain-containing adapter protein D

    Status: VALIDATED

    Source sequence(s)
    AC008616, BC007206
    UniProtKB/Swiss-Prot
    Q96NC2
    Conserved Domains (1) summary
    cd10390
    Location:238335
    SH2_SHD; Src homology 2 domain found in SH2 domain-containing adapter proteins D (SHD)
  2. NM_020209.4NP_064594.3  SH2 domain-containing adapter protein D

    See identical proteins and their annotated locations for NP_064594.3

    Status: VALIDATED

    Source sequence(s)
    AC008616, BC007206
    Consensus CDS
    CCDS12125.1
    UniProtKB/Swiss-Prot
    Q96IW2, Q96NC2
    Related
    ENSP00000446058.1, ENST00000543264.7
    Conserved Domains (1) summary
    cd10390
    Location:238335
    SH2_SHD; Src homology 2 domain found in SH2 domain-containing adapter proteins D (SHD)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    4279069..4290722
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    4262345..4273993
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)