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NIT2 nitrilase family member 2 [ Homo sapiens (human) ]

Gene ID: 56954, updated on 1-Jun-2020

Summary

Official Symbol
NIT2provided by HGNC
Official Full Name
nitrilase family member 2provided by HGNC
Primary source
HGNC:HGNC:29878
See related
Ensembl:ENSG00000114021 MIM:616769
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HEL-S-8a
Expression
Ubiquitous expression in kidney (RPKM 49.7), liver (RPKM 37.5) and 25 other tissues See more
Orthologs

Genomic context

See NIT2 in Genome Data Viewer
Location:
3q12.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (100334757..100361635)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (100053483..100075844)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene vesicle transport through interaction with t-SNAREs 1B pseudogene 1 Neighboring gene TBC1 domain family member 23 Neighboring gene translocase of outer mitochondrial membrane 70 Neighboring gene leukemia NUP98 fusion partner 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC111199

Gene Ontology Provided by GOA

Function Evidence Code Pubs
omega-amidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
omega-amidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
asparagine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
asparagine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
glutamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutamine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
oxaloacetate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxaloacetate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
specific granule lumen TAS
Traceable Author Statement
more info
 
tertiary granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
omega-amidase NIT2
Names
Nit protein 2
epididymis secretory sperm binding protein Li 8a
nitrilase homolog 2
NP_064587.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020202.5NP_064587.1  omega-amidase NIT2

    See identical proteins and their annotated locations for NP_064587.1

    Status: VALIDATED

    Source sequence(s)
    AC093003, AF284574, BM748852, DB466042
    Consensus CDS
    CCDS33806.1
    UniProtKB/Swiss-Prot
    Q9NQR4
    UniProtKB/TrEMBL
    V9HW91
    Related
    ENSP00000377696.3, ENST00000394140.9
    Conserved Domains (1) summary
    cd07572
    Location:5265
    nit; Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    100334757..100361635
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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