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OLFML3 olfactomedin like 3 [ Homo sapiens (human) ]

Gene ID: 56944, updated on 4-Oct-2020

Summary

Official Symbol
OLFML3provided by HGNC
Official Full Name
olfactomedin like 3provided by HGNC
Primary source
HGNC:HGNC:24956
See related
Ensembl:ENSG00000116774 MIM:610088
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OLF44; HNOEL-iso
Summary
This gene encodes a member of the olfactomedin-like gene family which also includes genes encoding noelin, tiarin, myocilin, amassin, optimedin, photomedin, and latrophilin. The encoded protein is a secreted extracellular matrix glycoprotein with a C-terminal olfactomedin domain that facilitates protein-protein interactions, cell adhesion, and intercellular interactions. It serves as both a scaffold protein that recruits bone morphogenetic protein 1 to its substrate chordin, and as a vascular tissue remodeler with pro-angiogenic properties. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Expression
Broad expression in ovary (RPKM 65.9), endometrium (RPKM 56.6) and 23 other tissues See more
Orthologs

Genomic context

See OLFML3 in Genome Data Viewer
Location:
1p13.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (113979474..113982254)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (114522030..114524875)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene GATA motif-containing MPRA enhancer 196 Neighboring gene HIPK1 antisense RNA 1 Neighboring gene homeodomain interacting protein kinase 1 Neighboring gene ribosomal protein L13a pseudogene 10 Neighboring gene synaptotagmin 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular vesicle HDA PubMed 

General protein information

Preferred Names
olfactomedin-like protein 3
Names
olfactomedin, 44-kd

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053036.1 RefSeqGene

    Range
    5084..7863
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001286352.3NP_001273281.1  olfactomedin-like protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001273281.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate exon in the 5' UTR and coding region and initiates translation from an alternate start codon compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AA576955, AK092766, AL731797
    Consensus CDS
    CCDS65618.1
    UniProtKB/Swiss-Prot
    Q9NRN5
    Related
    ENSP00000358564.1, ENST00000369551.5
    Conserved Domains (1) summary
    pfam02191
    Location:119377
    OLF; Olfactomedin-like domain
  2. NM_001286353.3NP_001273282.1  olfactomedin-like protein 3 isoform 3

    See identical proteins and their annotated locations for NP_001273282.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an an alternate splice site in the 5' UTR which results in the use of a downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AA576955, AL731797, BP201458
    Consensus CDS
    CCDS72839.1
    UniProtKB/TrEMBL
    B4DNG0
    Related
    ENSP00000376977.3, ENST00000393300.6
    Conserved Domains (1) summary
    pfam02191
    Location:78336
    OLF; Olfactomedin-like domain
  3. NM_020190.5NP_064575.1  olfactomedin-like protein 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_064575.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AY464015
    Consensus CDS
    CCDS870.1
    UniProtKB/Swiss-Prot
    Q9NRN5
    UniProtKB/TrEMBL
    M1LAK4
    Related
    ENSP00000322273.4, ENST00000320334.5
    Conserved Domains (2) summary
    pfam02191
    Location:139397
    OLF; Olfactomedin-like domain
    cl28015
    Location:25100
    PspA_IM30; PspA/IM30 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    113979474..113982254
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001848.2XP_016857337.1  olfactomedin-like protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q9NRN5
    Conserved Domains (1) summary
    pfam02191
    Location:119377
    OLF; Olfactomedin-like domain
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