grk3 G protein-coupled receptor kinase 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: grk3provided by ZNC
Official Full Name: G protein-coupled receptor kinase 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-030616-382
See related: Ensembl:ENSDARG00000104094 AllianceGenome:ZFIN:ZDB-GENE-030616-382
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: adrbk2; si:dz221d18.1
Summary: Enables protein kinase activity. Acts upstream of or within several processes, including heart rudiment formation; muscle cell development; and smoothened signaling pathway. Is expressed in several structures, including heart; immature eye; nervous system; notochord; and tail bud. Orthologous to several human genes including GRK3 (G protein-coupled receptor kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 10

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (44055656..44198656)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (44208831..44351911)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

beta-arrestin 2 and GRK2 colocalize with S1p2 in developing zebrafish embryos and depletion of GRK2 in the S1p2 R150H miles apart zebrafish partially rescued cardia bifida.
Title: Phenotypic regulation of the sphingosine 1-phosphate receptor miles apart by G protein-coupled receptor kinase 2.
GRK2 and GRK5 control cardiac function as well as morphogenesis during development although with different morphological outcomes.
Title: Overlapping and opposing functions of G protein-coupled receptor kinase 2 (GRK2) and GRK5 during heart development.
These data thus reveal a novel kinase activity-independent function for GRK and establish a role for GRK2 as a cell-cycle regulator during early embryonic development.
Title: Kinase activity-independent regulation of cyclin pathway by GRK2 is essential for zebrafish early development.
Data suggest that a G protein-coupled receptor kinase, perhaps GRK2 or 3, functions as a vertebrate kinase for Smoothened, promoting Hedgehog signal transduction during early development.
Title: Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chordate embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart rudiment formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within muscle cell development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in postsynapse	IEA Inferred from Electronic Annotation more info
located_in presynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: beta-adrenergic receptor kinase 2

Names: G-protein coupled receptor kinase 2/3; GRK2/3; adrenergic, beta, receptor kinase 2

NP_001128197.1

EC 2.7.11.15

XP_009303964.1

EC 2.7.11.15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134725.1 → NP_001128197.1 beta-adrenergic receptor kinase 2

See identical proteins and their annotated locations for NP_001128197.1

Status: PROVISIONAL

Source sequence(s)

EU924796

UniProtKB/TrEMBL

A0A8M1NL83, B5LZ08

Related

ENSDARP00000132518.1, ENSDART00000164610.3

Conserved Domains (5) summary

cd08747
Location:30 → 186

RGS_GRK2_GRK3; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 2 (GRK2) and G protein-coupled receptor kinase 3 (GRK3)

cd01240
Location:553 → 670

PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain

cd05633
Location:185 → 530

STKc_GRK3; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 3

pfam00069
Location:191 → 453

Pkinase; Protein kinase domain

pfam00169
Location:560 → 650

PH; PH domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007121.7 Reference GRCz11 Primary Assembly

Range

44055656..44198656

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009305689.3 → XP_009303964.1 beta-adrenergic receptor kinase 2 isoform X1

UniProtKB/TrEMBL

A0A2R8QPB8, A0A8M3B3P8

Related

ENSDARP00000157494.1, ENSDART00000183868.1

Conserved Domains (5) summary

cd08747
Location:30 → 186

RGS_GRK2_GRK3; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 2 (GRK2) and G protein-coupled receptor kinase 3 (GRK3)

cd01240
Location:553 → 683

PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain

pfam00069
Location:191 → 453

Pkinase; Protein kinase domain

pfam00169
Location:560 → 663

PH; PH domain

cl21453
Location:185 → 530

PKc_like; Protein Kinases, catalytic domain