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jade2 jade family PHD finger 2 [ Danio rerio (zebrafish) ]

Gene ID: 569359, updated on 9-Sep-2025
Official Symbol
jade2provided by ZNC
Official Full Name
jade family PHD finger 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-120215-66
See related
Ensembl:ENSDARG00000053389 AllianceGenome:ZFIN:ZDB-GENE-120215-66
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
phf15; si:ch73-202g8.3
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of histone acetyltransferase complex. Orthologous to human JADE2 (jade family PHD finger 2). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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Location:
chromosome: 21
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 21 NC_133196.1 (49542071..49570133)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 21 NC_007132.7 (45385672..45411509)

Chromosome 21 - NC_133196.1Genomic Context describing neighboring genes Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 Neighboring gene CDKN2A interacting protein N-terminal like Neighboring gene uncharacterized LOC137488873 Neighboring gene ubiquitin-conjugating enzyme E2B (RAD6 homolog) Neighboring gene uncharacterized LOC141380040

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Destabilizing LSD1 by Jade-2 promotes neurogenesis: an antibraking system in neural development. Han X, et al. Mol Cell, 2014 Aug 7. PMID 25018020
  2. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
  3. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
protein Jade-2; E3 ubiquitin-protein ligase Jade-2
Names
PHD finger protein 15

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RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133196.1 Reference GRCz12tu Primary Assembly

    Range
    49542071..49570133
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_692739.11 → XP_697831.5  E3 ubiquitin-protein ligase Jade-2

    UniProtKB/TrEMBL
    A0A8N7TBV7, E7F8E2
    Related
    ENSDARP00000069915.4
    Conserved Domains (3) summary
    COG5141
    Location:107 → 515
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15680
    Location:196 → 241
    PHD_JADE2; PHD finger found in protein Jade-2 and similar proteins
    cd15705
    Location:249 → 359
    ePHD_JADE2; Extended PHD finger found in protein Jade-2 and similar proteins

RNA

  1. XR_012396995.1 RNA Sequence

  2. XR_012396996.1 RNA Sequence

  3. XR_012396997.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials