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SMCO4 single-pass membrane protein with coiled-coil domains 4 [ Homo sapiens (human) ]

Gene ID: 56935, updated on 9-Jun-2025
Official Symbol
SMCO4provided by HGNC
Official Full Name
single-pass membrane protein with coiled-coil domains 4provided by HGNC
Primary source
HGNC:HGNC:24810
See related
Ensembl:ENSG00000166002 MIM:609477; AllianceGenome:HGNC:24810
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FN5; C11orf75
Summary
Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Ubiquitous expression in salivary gland (RPKM 8.9), prostate (RPKM 7.3) and 25 other tissues See more
Orthologs
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See SMCO4 in Genome Data Viewer
Location:
11q21
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (93478472..93553979, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (93394933..93470364, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (93211638..93276557, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATP synthase subunit ATP5MJ, mitochondrial-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5388 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5389 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3835 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:93063547-93064048 Neighboring gene uncharacterized LOC124902734 Neighboring gene deuterosome assembly protein 1 Neighboring gene NANOG hESC enhancer GRCh37_chr11:93131833-93132334 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:93154443-93155082 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:93177550-93178122 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5390 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5391 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5393 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5394 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5395 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5396 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:93270830-93271376 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3836 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3837 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3838 Neighboring gene SRP14 pseudogene 2 Neighboring gene RNA, 7SL, cytoplasmic 223, pseudogene Neighboring gene HemK methyltransferase 2, ETF1 glutamine and histone H4 lysine pseudogene

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Characterization of the Fugu rubripes NLK and FN5 genes flanking the NF1 (Neurofibromatosis type 1) gene in the 5' direction and mapping of the human counterparts. Kehrer-Sawatzki H, et al. Gene, 2000 Jun 13. PMID 10863097
  2. Systematic identification of pathological lamin A interactors. Dittmer TA, et al. Mol Biol Cell, 2014 May. PMID 24623722, Free PMC Article
  3. Assessment of community efforts to advance network-based prediction of protein-protein interactions. Wang XW, et al. Nat Commun, 2023 Mar 22. PMID 36949045, Free PMC Article
  4. Next-generation sequencing to generate interactome datasets. Yu H, et al. Nat Methods, 2011 Jun. PMID 21516116, Free PMC Article
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
single-pass membrane and coiled-coil domain-containing protein 4
Names
UPF0443 protein C11orf75

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020179.3 → NP_064564.1  single-pass membrane and coiled-coil domain-containing protein 4

    See identical proteins and their annotated locations for NP_064564.1

    Status: VALIDATED

    Source sequence(s)
    AF197137, AP003499, BC031564
    Consensus CDS
    CCDS8292.1
    UniProtKB/Swiss-Prot
    Q9NRQ5
    UniProtKB/TrEMBL
    E9PQ76
    Related
    ENSP00000298966.2, ENST00000298966.7
    Conserved Domains (1) summary
    pfam15012
    Location:1 → 55
    DUF4519; Domain of unknown function (DUF4519)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    93478472..93553979 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542909.1 → XP_011541211.1  single-pass membrane and coiled-coil domain-containing protein 4 isoform X2

  2. XM_011542907.1 → XP_011541209.1  single-pass membrane and coiled-coil domain-containing protein 4 isoform X1

  3. XM_017018020.1 → XP_016873509.1  single-pass membrane and coiled-coil domain-containing protein 4 isoform X3

  4. XM_047427266.1 → XP_047283222.1  single-pass membrane and coiled-coil domain-containing protein 4 isoform X4

  5. XM_011542911.3 → XP_011541213.1  single-pass membrane and coiled-coil domain-containing protein 4 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    93394933..93470364 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369383.1 → XP_054225358.1  single-pass membrane and coiled-coil domain-containing protein 4 isoform X2

  2. XM_054369382.1 → XP_054225357.1  single-pass membrane and coiled-coil domain-containing protein 4 isoform X1

  3. XM_054369384.1 → XP_054225359.1  single-pass membrane and coiled-coil domain-containing protein 4 isoform X3

  4. XM_054369386.1 → XP_054225361.1  single-pass membrane and coiled-coil domain-containing protein 4 isoform X4

  5. XM_054369385.1 → XP_054225360.1  single-pass membrane and coiled-coil domain-containing protein 4 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NRQ5.1 GenPept UniProtKB/Swiss-Prot:Q9NRQ5

Gene LinkOut

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