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CA10 carbonic anhydrase 10 [ Homo sapiens (human) ]

Gene ID: 56934, updated on 8-Oct-2018

Summary

Official Symbol
CA10provided by HGNC
Official Full Name
carbonic anhydrase 10provided by HGNC
Primary source
HGNC:HGNC:1369
See related
Ensembl:ENSG00000154975 MIM:604642; Vega:OTTHUMG00000177544
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CARPX; CA-RPX; HUCEP-15
Summary
This gene encodes a protein that belongs to the carbonic anhydrase family of zinc metalloenzymes, which catalyze the reversible hydration of carbon dioxide in various biological processes. The protein encoded by this gene is an acatalytic member of the alpha-carbonic anhydrase subgroup, and it is thought to play a role in the central nervous system, especially in brain development. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 15.3), kidney (RPKM 2.4) and 2 other tissues See more
Orthologs

Genomic context

See CA10 in Genome Data Viewer
Location:
17q21.33-q22
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (51630313..52160017, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (49707674..50237377, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2073 Neighboring gene ribosomal protein L7 pseudogene 48 Neighboring gene carbonic anhydrase 10 repeat instability region Neighboring gene uncharacterized LOC105371829 Neighboring gene long intergenic non-protein coding RNA 1982

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
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NHGRI GWA Catalog
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
NHGRI GWA Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
NHGRI GWA Catalog
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbonate dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
brain development NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
carbonic anhydrase-related protein 10
Names
CA-RP X
CARP X
carbonic anhydrase X
carbonic anhydrase-related protein X
cerebral protein-15
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082533.1NP_001076002.1  carbonic anhydrase-related protein 10 precursor

    See identical proteins and their annotated locations for NP_001076002.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC005883, AW135066, BC047456, DA110822
    Consensus CDS
    CCDS32684.1
    UniProtKB/Swiss-Prot
    Q9NS85
    Related
    ENSP00000285273.4, OTTHUMP00000256923, ENST00000285273.8, OTTHUMT00000437480
    Conserved Domains (1) summary
    cd03121
    Location:46302
    alpha_CARP_X_XI_like; Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are ...
  2. NM_001082534.1NP_001076003.1  carbonic anhydrase-related protein 10 precursor

    See identical proteins and their annotated locations for NP_001076003.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC005883, AF288385, AW135066, DA518921
    Consensus CDS
    CCDS32684.1
    UniProtKB/Swiss-Prot
    Q9NS85
    Related
    ENSP00000390666.2, OTTHUMP00000256920, ENST00000442502.6, OTTHUMT00000437477
    Conserved Domains (1) summary
    cd03121
    Location:46302
    alpha_CARP_X_XI_like; Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are ...
  3. NM_020178.4NP_064563.1  carbonic anhydrase-related protein 10 precursor

    See identical proteins and their annotated locations for NP_064563.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC005883, AW135066, BC047456, DA128892
    Consensus CDS
    CCDS32684.1
    UniProtKB/Swiss-Prot
    Q9NS85
    Related
    ENSP00000405388.2, OTTHUMP00000256922, ENST00000451037.6, OTTHUMT00000437479
    Conserved Domains (1) summary
    cd03121
    Location:46302
    alpha_CARP_X_XI_like; Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    51630313..52160017 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024878.2XP_016880367.1  carbonic anhydrase-related protein 10 isoform X1

    Related
    ENSP00000459619.1, OTTHUMP00000256919, ENST00000570565.5
    Conserved Domains (1) summary
    cd03121
    Location:1205
    alpha_CARP_X_XI_like; Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are ...
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