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DUS3L dihydrouridine synthase 3 like [ Homo sapiens (human) ]

Gene ID: 56931, updated on 1-Jun-2020

Summary

Official Symbol
DUS3Lprovided by HGNC
Official Full Name
dihydrouridine synthase 3 likeprovided by HGNC
Primary source
HGNC:HGNC:26920
See related
Ensembl:ENSG00000141994
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DUS3
Expression
Ubiquitous expression in testis (RPKM 13.5), bone marrow (RPKM 10.1) and 25 other tissues See more
Orthologs

Genomic context

See DUS3L in Genome Data Viewer
Location:
19p13.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (5785136..5791210, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (5785151..5791249, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene lon peptidase 1, mitochondrial Neighboring gene cation channel sperm associated auxiliary subunit delta Neighboring gene proline rich 22 Neighboring gene neurturin Neighboring gene fucosyltransferase 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13896

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
tRNA dihydrouridine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
tRNA dihydrouridine synthesis IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like
NP_001155091.1
NP_064560.2
XP_016882509.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161619.2NP_001155091.1  tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like isoform 2

    See identical proteins and their annotated locations for NP_001155091.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    BC004549
    Consensus CDS
    CCDS54202.1
    UniProtKB/Swiss-Prot
    Q96G46
    Related
    ENSP00000315558.7, ENST00000320699.12
    Conserved Domains (2) summary
    COG0042
    Location:55334
    DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
    cd02801
    Location:64296
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
  2. NM_020175.3NP_064560.2  tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like isoform 1

    See identical proteins and their annotated locations for NP_064560.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC011499, AK315691, BC008362
    Consensus CDS
    CCDS32880.1
    UniProtKB/Swiss-Prot
    Q96G46
    UniProtKB/TrEMBL
    B2RDV7
    Related
    ENSP00000311977.5, ENST00000309061.12
    Conserved Domains (2) summary
    COG0042
    Location:297576
    DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
    cd02801
    Location:306538
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    5785136..5791210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027020.1XP_016882509.1  tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like isoform X1

RNA

  1. XR_936193.2 RNA Sequence

  2. XR_244033.1 RNA Sequence

    Related
    ENST00000589085.5
  3. XR_002958335.1 RNA Sequence

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