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NCLN nicalin [ Homo sapiens (human) ]

Gene ID: 56926, updated on 7-Aug-2021

Summary

Official Symbol
NCLNprovided by HGNC
Official Full Name
nicalinprovided by HGNC
Primary source
HGNC:HGNC:26923
See related
Ensembl:ENSG00000125912 MIM:609156
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NET59
Expression
Ubiquitous expression in colon (RPKM 14.1), duodenum (RPKM 12.9) and 25 other tissues See more
Orthologs
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Genomic context

See NCLN in Genome Data Viewer
Location:
19p13.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (3185930..3209575)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (3185928..3209573)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 13242 Neighboring gene G protein subunit alpha 15 Neighboring gene sphingosine-1-phosphate receptor 4 Neighboring gene CUGBP Elav-like family member 5 Neighboring gene uncharacterized LOC105372244 Neighboring gene skeletal muscle cis-regulatory module in NFIC intron Neighboring gene nuclear factor I C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metalloexopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ribosome binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of protein complex stability IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane HDA PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nicalin
Names
nicalin homolog
nicastrin-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321463.2NP_001308392.1  nicalin isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC011547, BC025926, BG420915, BU508470, GD158011
    UniProtKB/Swiss-Prot
    Q969V3
    Conserved Domains (1) summary
    cd03882
    Location:130429
    M28_nicalin_like; M28 Zn-Peptidase Nicalin, Nicastrin-like protein
  2. NM_020170.4NP_064555.2  nicalin isoform 1 precursor

    See identical proteins and their annotated locations for NP_064555.2

    Status: VALIDATED

    Source sequence(s)
    AL136567, AL365369, BC003076, BC007275, BC008920, BC010064, BC013283, BC025926
    Consensus CDS
    CCDS32869.1
    UniProtKB/Swiss-Prot
    Q969V3
    Related
    ENSP00000246117.3, ENST00000246117.9
    Conserved Domains (1) summary
    cd03882
    Location:127429
    M28_nicalin_like; M28 Zn-Peptidase Nicalin, Nicastrin-like protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    3185930..3209575
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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