hpn hepsin [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hpnprovided by ZNC
Official Full Name: hepsinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-141212-373
See related: Ensembl:ENSDARG00000027609 AllianceGenome:ZFIN:ZDB-GENE-141212-373
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkey-33i11.3; si:ch73-124g13.3
Summary: Predicted to enable serine-type endopeptidase activity and serine-type exopeptidase activity. Acts upstream of or within blood coagulation, fibrin clot formation and regulation of serine-type endopeptidase activity. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human HPN (hepsin). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	16	NC_133191.1 (49711850..49751678, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (45248867..45288699, complement)

Chromosome 16 - NC_133191.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hepsin plays a physiologically important role in factor VII activation and hemostasis in zebrafish.
Title: Role of hepsin in factor VII activation in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type exopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood coagulation, fibrin clot formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of serine-type endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine protease hepsin

NP_001091657.2

EC 3.4.21.106

XP_021322406.1

EC 3.4.21.106

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001098187.2 → NP_001091657.2 serine protease hepsin

Status: VALIDATED

Source sequence(s)

JBMGRA010000016

UniProtKB/TrEMBL

A5D6S2, A8DZG9

Related

ENSDARP00160014820.1, ENSDART00160027204.1

Conserved Domains (2) summary

cd00190
Location:164 → 404

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

cl02509
Location:54 → 160

SRCR_2; Scavenger receptor cysteine-rich domain

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

NC_133191.1 Reference GRCz12tu Primary Assembly

Range

49711850..49751678 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021466731.3 → XP_021322406.1 serine protease hepsin isoform X1

UniProtKB/TrEMBL

A0A8M9PJK7, A5D6S2

Conserved Domains (2) summary

cd00190
Location:152 → 392

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

cl02509
Location:42 → 148

SRCR_2; Scavenger receptor cysteine-rich domain