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NMUR2 neuromedin U receptor 2 [ Homo sapiens (human) ]

Gene ID: 56923, updated on 8-Jul-2021

Summary

Official Symbol
NMUR2provided by HGNC
Official Full Name
neuromedin U receptor 2provided by HGNC
Primary source
HGNC:HGNC:16454
See related
Ensembl:ENSG00000132911 MIM:605108
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FM4; FM-4; TGR1; NMU2R; TGR-1; NMU-R2
Summary
This gene encodes a protein from the G-protein coupled receptor 1 family. This protein is a receptor for neuromedin U, which is a neuropeptide that is widely distributed in the gut and central nervous system. This receptor plays an important role in the regulation of food intake and body weight. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See NMUR2 in Genome Data Viewer
Location:
5q33.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (152391546..152405279, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (151771107..151784840, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378236 Neighboring gene uncharacterized LOC105378237 Neighboring gene ribosomal protein L36a pseudogene 20 Neighboring gene tRNA-Cys (anticodon ACA) 1-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association identifies ATOH7 as a major gene determining human optic disc size.
GeneReviews: Not available
Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
GeneReviews: Not available
Genome-wide association study of chronic periodontitis in a general German population.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables intracellular calcium activated chloride channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables neuromedin U binding IDA
Inferred from Direct Assay
more info
PubMed 
enables neuromedin U receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables neuropeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in activation of phospholipase A2 activity by calcium-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in arachidonic acid secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in calcium-mediated signaling NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
involved_in central nervous system development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in feeding behavior TAS
Traceable Author Statement
more info
PubMed 
involved_in grooming behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in inorganic anion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in inositol phosphate-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in reduction of food intake in response to dietary excess IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of smooth muscle contraction NAS
Non-traceable Author Statement
more info
PubMed 
involved_in response to pain IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
neuromedin-U receptor 2
Names
G-protein coupled receptor FM-4
G-protein coupled receptor TGR-1
growth hormone secretagogue receptor family, member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020167.5NP_064552.3  neuromedin-U receptor 2

    See identical proteins and their annotated locations for NP_064552.3

    Status: REVIEWED

    Source sequence(s)
    AC008571, AI023570, BC067776
    Consensus CDS
    CCDS4321.1
    UniProtKB/Swiss-Prot
    Q9GZQ4
    Related
    ENSP00000255262.4, ENST00000255262.4
    Conserved Domains (1) summary
    pfam00001
    Location:62327
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    152391546..152405279 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537670.2XP_011535972.1  neuromedin-U receptor 2 isoform X1

    Conserved Domains (1) summary
    pfam00001
    Location:62286
    7tm_1; 7 transmembrane receptor (rhodopsin family)
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