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MAP3K7CL MAP3K7 C-terminal like [ Homo sapiens (human) ]

Gene ID: 56911, updated on 7-Oct-2019

Summary

Official Symbol
MAP3K7CLprovided by HGNC
Official Full Name
MAP3K7 C-terminal likeprovided by HGNC
Primary source
HGNC:HGNC:16457
See related
Ensembl:ENSG00000156265 MIM:611110
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TAKL; TAK1L; TAKL-1; TAKL-2; TAKL-4; C21orf7; HC21ORF7
Expression
Ubiquitous expression in heart (RPKM 4.1), prostate (RPKM 2.4) and 24 other tissues See more
Orthologs

Genomic context

See MAP3K7CL in Genome Data Viewer
Location:
21q21.3
Exon count:
18
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (29077114..29175889)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (30449659..30548210)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 16 Neighboring gene chaperonin containing TCP1 subunit 8 Neighboring gene Sharpr-MPRA regulatory region 4059 Neighboring gene ribosomal protein L12 pseudogene 9 Neighboring gene uncharacterized LOC105372767 Neighboring gene long intergenic non-protein coding RNA 189 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association scan of dental caries in the permanent dentition.
NHGRI GWA Catalog

Pathways from BioSystems

  • Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
    Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytosol HDA PubMed 
nucleus HDA PubMed 

General protein information

Preferred Names
MAP3K7 C-terminal-like protein
Names
TAK1-like protein 1
TAK1-like protein 2
TAK1-like protein 4
TGF-beta activated kinase

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286617.2NP_001273546.1  MAP3K7 C-terminal-like protein isoform 2

    See identical proteins and their annotated locations for NP_001273546.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks 2 exons in the 5' region and contains 2 additional exons, which result in translation initiation from an alternate start codon compared to variant 1. The resulting shorter isoform (2) has a distinct N-terminus compared to isoform 1. Variants 3-6 encode the same isoform.
    Source sequence(s)
    AF129075, AF269162, EF219157
    Consensus CDS
    CCDS68182.1
    UniProtKB/Swiss-Prot
    P57077
    UniProtKB/TrEMBL
    B0EVZ6, B0EVZ8
    Related
    ENSP00000382817.2, ENST00000399935.6
    Conserved Domains (1) summary
    TIGR04211
    Location:39142
    SH3_and_anchor; SH3 domain protein
  2. NM_001286618.2NP_001273547.1  MAP3K7 C-terminal-like protein isoform 2

    See identical proteins and their annotated locations for NP_001273547.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks 2 exons in the 5' region and contains an additional exon, which results in translation initiation from an alternate start codon compared to variant 1. The resulting shorter isoform (2) has a distinct N-terminus compared to isoform 1. Variants 3-6 encode the same isoform.
    Source sequence(s)
    AF129075, AF269163, EF219157
    Consensus CDS
    CCDS68182.1
    UniProtKB/Swiss-Prot
    P57077
    UniProtKB/TrEMBL
    B0EVZ6, B0EVZ8
    Related
    ENSP00000382816.1, ENST00000399934.5
    Conserved Domains (1) summary
    TIGR04211
    Location:39142
    SH3_and_anchor; SH3 domain protein
  3. NM_001286619.1NP_001273548.1  MAP3K7 C-terminal-like protein isoform 2

    See identical proteins and their annotated locations for NP_001273548.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has an alternate 5' end and contains 3 additional exons, which result in translation initiation from an alternate start codon compared to variant 1. The resulting shorter isoform (2) has a distinct N-terminus compared to isoform 1. Variants 3-6 encode the same isoform.
    Source sequence(s)
    AF269162, AK122780, AK294287, BG566433, BX108010
    Consensus CDS
    CCDS68182.1
    UniProtKB/Swiss-Prot
    P57077
    UniProtKB/TrEMBL
    B0EVZ8, B4DFW0
    Related
    ENSP00000345777.4, ENST00000339024.8
    Conserved Domains (1) summary
    TIGR04211
    Location:39142
    SH3_and_anchor; SH3 domain protein
  4. NM_001286620.2NP_001273549.1  MAP3K7 C-terminal-like protein isoform 2

    See identical proteins and their annotated locations for NP_001273549.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains alternate 5' end exons that result in translation initiation from an alternate start codon compared to variant 1. The resulting shorter isoform (2) has a distinct N-terminus compared to isoform 1. Variants 3-6 encode the same isoform.
    Source sequence(s)
    AF269161, BC008567
    Consensus CDS
    CCDS68182.1
    UniProtKB/Swiss-Prot
    P57077
    UniProtKB/TrEMBL
    B0EVZ8
    Related
    ENSP00000382812.1, ENST00000399928.5
    Conserved Domains (1) summary
    TIGR04211
    Location:39142
    SH3_and_anchor; SH3 domain protein
  5. NM_001286622.2NP_001273551.1  MAP3K7 C-terminal-like protein isoform 3

    See identical proteins and their annotated locations for NP_001273551.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks 2 exons in the 5' region and contains an additional exon, which results in translation initiation from an alternate start codon compared to variant 1. The resulting shorter isoform (3) has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AF129075, AF269161, AK294287, EF219157
    Consensus CDS
    CCDS74775.1
    UniProtKB/Swiss-Prot
    P57077
    UniProtKB/TrEMBL
    B0EVZ6, B4DFW0
    Related
    ENSP00000437846.1, ENST00000545939.5
    Conserved Domains (1) summary
    cl09232
    Location:54124
    YqaJ; YqaJ-like viral recombinase domain
  6. NM_001286623.2NP_001273552.1  MAP3K7 C-terminal-like protein isoform 4

    See identical proteins and their annotated locations for NP_001273552.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks a non-coding exon in the 5' region and contains an alternate 3' terminal exon compared to variant 1. The resulting shorter isoform (4) has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF129075, EF219157
    UniProtKB/TrEMBL
    B0EVZ6
  7. NM_001286624.2NP_001273553.1  MAP3K7 C-terminal-like protein isoform 5

    See identical proteins and their annotated locations for NP_001273553.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks many exons from the 5' and mid region and contains an alternate 5' terminal exon, which results in translation initiation from an in-frame downstream start codon compared to variant 1. The resulting isoform (5) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AF269161, AK309998, BI911525
    UniProtKB/Swiss-Prot
    P57077
    UniProtKB/TrEMBL
    B0EVZ7
    Conserved Domains (1) summary
    pfam04111
    Location:1281
    APG6; Autophagy protein Apg6
  8. NM_001286634.2NP_001273563.1  MAP3K7 C-terminal-like protein isoform 1

    See identical proteins and their annotated locations for NP_001273563.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks 2 exons in the 5' non-coding region compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AF129075, AF269161, EF219157
    Consensus CDS
    CCDS13584.1
    UniProtKB/Swiss-Prot
    P57077
    UniProtKB/TrEMBL
    B0EVZ6
    Related
    ENSP00000343212.4, ENST00000341618.8
    Conserved Domains (2) summary
    TIGR04211
    Location:118242
    SH3_and_anchor; SH3 domain protein
    pfam08647
    Location:173234
    BRE1; BRE1 E3 ubiquitin ligase
  9. NM_001371369.1NP_001358298.1  MAP3K7 C-terminal-like protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AF124730, AF129075
  10. NM_001371370.1NP_001358299.1  MAP3K7 C-terminal-like protein isoform 6

    Status: VALIDATED

    Source sequence(s)
    AF124730, AF129075
  11. NM_001371371.1NP_001358300.1  MAP3K7 C-terminal-like protein isoform 7

    Status: VALIDATED

    Source sequence(s)
    AF124730, AF129075, BP290461, DA021298
  12. NM_001371372.1NP_001358301.1  MAP3K7 C-terminal-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AF124730, EF219159
    Related
    ENSP00000382809.1, ENST00000399925.5
  13. NM_001371373.1NP_001358302.1  MAP3K7 C-terminal-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AF124730, AF129075, CB963708
    Related
    ENSP00000382810.1, ENST00000399926.5
  14. NM_001371374.1NP_001358303.1  MAP3K7 C-terminal-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AF124730, AF129075
  15. NM_001371376.1NP_001358305.1  MAP3K7 C-terminal-like protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AF124730, AF129075, EF219158
  16. NM_020152.4NP_064537.1  MAP3K7 C-terminal-like protein isoform 1

    See identical proteins and their annotated locations for NP_064537.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AF129075, AF269161, AY171599, EF219157
    Consensus CDS
    CCDS13584.1
    UniProtKB/Swiss-Prot
    P57077
    UniProtKB/TrEMBL
    B0EVZ6
    Related
    ENSP00000382828.2, ENST00000399947.6
    Conserved Domains (2) summary
    TIGR04211
    Location:118242
    SH3_and_anchor; SH3 domain protein
    pfam08647
    Location:173234
    BRE1; BRE1 E3 ubiquitin ligase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    29077114..29175889
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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