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rerea arginine-glutamic acid dipeptide (RE) repeats a [ Danio rerio (zebrafish) ]

Gene ID: 569081, updated on 9-Sep-2025
Official Symbol
rereaprovided by ZNC
Official Full Name
arginine-glutamic acid dipeptide (RE) repeats aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060718-1
See related
Ensembl:ENSDARG00000077353 AllianceGenome:ZFIN:ZDB-GENE-060718-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
rere; atrophin2
Summary
Enables transcription corepressor binding activity. Acts upstream of or within several processes, including closure of optic fissure; pharyngeal system development; and regulation of signal transduction. Predicted to be active in nucleus. Is expressed in several structures, including germ ring; gut; head; nervous system; and pectoral fin bud. Orthologous to human RERE (arginine-glutamic acid dipeptide repeats). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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See rerea in Genome Data Viewer
Location:
chromosome: 23
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 23 NC_133198.1 (25629267..25867489)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 23 NC_007134.7 (22690374..22928600)

Chromosome 23 - NC_133198.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 2 member 5 Neighboring gene carbonic anhydrase VI Neighboring gene enolase 1a, (alpha) Neighboring gene uncharacterized LOC101883493 Neighboring gene uncharacterized LOC141380490 Neighboring gene sterile alpha motif domain containing 11

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Mutation of the atrophin2 gene in the zebrafish disrupts signaling by fibroblast growth factor during development of the inner ear. Asai Y, et al. Proc Natl Acad Sci U S A, 2006 Jun 13. PMID 16754885, Free PMC Article
  2. Fat-Dachsous signaling coordinates cartilage differentiation and polarity during craniofacial development. Le Pabic P, et al. PLoS Genet, 2014 Oct. PMID 25340762, Free PMC Article
  3. Zebrafish model of RERE syndrome recapitulates key ophthalmic defects that are rescued by small molecule inhibitor of shh signaling. George A, et al. Dev Dyn, 2023 Apr. PMID 36576487, Free PMC Article
  4. Atrophin-Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR. Zhang Z, et al. J Cell Biol, 2013 Nov 25. PMID 24385484, Free PMC Article
  5. REREa/Atrophin-2 interacts with histone deacetylase and Fgf8 signaling to regulate multiple processes of zebrafish development. Plaster N, et al. Dev Dyn, 2007 Jul. PMID 17576618

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zebrafish model of RERE syndrome recapitulates key ophthalmic defects that are rescued by small molecule inhibitor of shh signaling.
    Title: Zebrafish model of RERE syndrome recapitulates key ophthalmic defects that are rescued by small molecule inhibitor of shh signaling.
  2. Results suggest that atrophin2 plays a role in the feedback regulation of Fgf8 signaling.
    Title: Mutation of the atrophin2 gene in the zebrafish disrupts signaling by fibroblast growth factor during development of the inner ear.
  3. the Atro-Rpd3 complex plays a conserved role to function as a Ci(R) corepressor.
    Title: Atrophin-Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR.
  4. Tissue-specific transcriptional repression, by means of an REREa-Histone Deacetylase complex, modulates growth factor signaling during embryogenesis.
    Title: REREa/Atrophin-2 interacts with histone deacetylase and Fgf8 signaling to regulate multiple processes of zebrafish development.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cartilage development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cartilage morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within closure of optic fissure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within inner ear development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pharyngeal system development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within pharyngeal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of fibroblast growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
arginine-glutamic acid dipeptide repeats protein
Names
atrophin 2
bab
babyface
gap
gaping mouth
rereb

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133198.1 Reference GRCz12tu Primary Assembly

    Range
    25629267..25867489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073938963.1 → XP_073795064.1  arginine-glutamic acid dipeptide repeats protein isoform X1

    UniProtKB/TrEMBL
    A0A8M2B939, E7F226

  2. XM_021469958.3 → XP_021325633.1  arginine-glutamic acid dipeptide repeats protein isoform X1

    UniProtKB/TrEMBL
    A0A8M2B939, E7F226
    Conserved Domains (5) summary
    cd11661
    Location:352 → 397
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:460 → 509
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:101 → 264
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:243 → 293
    ELM2; ELM2 domain
    cl26464
    Location:525 → 1530
    Atrophin-1; Atrophin-1 family

  3. XM_073938965.1 → XP_073795066.1  arginine-glutamic acid dipeptide repeats protein isoform X3

    UniProtKB/TrEMBL
    A0A8M2B917

  4. XM_005162203.6 → XP_005162260.1  arginine-glutamic acid dipeptide repeats protein isoform X1

    See identical proteins and their annotated locations for XP_005162260.1

    UniProtKB/TrEMBL
    A0A8M2B939, E7F226
    Related
    ENSDARP00000102789.2
    Conserved Domains (5) summary
    cd11661
    Location:352 → 397
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:460 → 509
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:101 → 264
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:243 → 293
    ELM2; ELM2 domain
    cl26464
    Location:525 → 1530
    Atrophin-1; Atrophin-1 family

  5. XM_073938964.1 → XP_073795065.1  arginine-glutamic acid dipeptide repeats protein isoform X3

    UniProtKB/TrEMBL
    A0A8M2B917

  6. XM_073938962.1 → XP_073795063.1  arginine-glutamic acid dipeptide repeats protein isoform X1

    UniProtKB/TrEMBL
    A0A8M2B939, E7F226

  7. XM_073938966.1 → XP_073795067.1  arginine-glutamic acid dipeptide repeats protein isoform X3

    UniProtKB/TrEMBL
    A0A8M2B917

  8. XM_009296906.5 → XP_009295181.1  arginine-glutamic acid dipeptide repeats protein isoform X2

    UniProtKB/TrEMBL
    A0A8M3AYH4
    Conserved Domains (7) summary
    smart00717
    Location:353 → 398
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:352 → 397
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:460 → 509
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:463 → 517
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    cd04709
    Location:101 → 264
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:243 → 293
    ELM2; ELM2 domain
    pfam03154
    Location:525 → 1520
    Atrophin-1; Atrophin-1 family

  9. XM_005162201.6 → XP_005162258.1  arginine-glutamic acid dipeptide repeats protein isoform X1

    See identical proteins and their annotated locations for XP_005162258.1

    UniProtKB/TrEMBL
    A0A8M2B939, E7F226
    Conserved Domains (5) summary
    cd11661
    Location:352 → 397
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:460 → 509
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:101 → 264
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:243 → 293
    ELM2; ELM2 domain
    cl26464
    Location:525 → 1530
    Atrophin-1; Atrophin-1 family

  10. XM_068216904.2 → XP_068073005.1  arginine-glutamic acid dipeptide repeats protein isoform X4

    UniProtKB/TrEMBL
    A0AB32TAW1

  11. XM_005162204.6 → XP_005162261.1  arginine-glutamic acid dipeptide repeats protein isoform X3

    UniProtKB/TrEMBL
    A0A8M2B917
    Related
    ENSDARP00000117039.1
    Conserved Domains (7) summary
    smart00717
    Location:353 → 398
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:352 → 397
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:460 → 509
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:463 → 517
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    cd04709
    Location:101 → 264
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:243 → 293
    ELM2; ELM2 domain
    pfam03154
    Location:525 → 1520
    Atrophin-1; Atrophin-1 family

  12. XM_073938967.1 → XP_073795068.1  arginine-glutamic acid dipeptide repeats protein isoform X6

  13. XM_001922746.8 → XP_001922781.3  arginine-glutamic acid dipeptide repeats protein isoform X5

    UniProtKB/TrEMBL
    A0A8M1QLN1
    Conserved Domains (7) summary
    smart00717
    Location:128 → 173
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:127 → 172
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:235 → 284
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:238 → 292
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    pfam01448
    Location:18 → 68
    ELM2; ELM2 domain
    pfam03154
    Location:300 → 1305
    Atrophin-1; Atrophin-1 family
    cl02608
    Location:8 → 39
    BAH; BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...

  14. XM_073938969.1 → XP_073795070.1  arginine-glutamic acid dipeptide repeats protein isoform X8

  15. XM_073938968.1 → XP_073795069.1  arginine-glutamic acid dipeptide repeats protein isoform X7

  16. XM_073938971.1 → XP_073795072.1  arginine-glutamic acid dipeptide repeats protein isoform X10

  17. XM_073938970.1 → XP_073795071.1  arginine-glutamic acid dipeptide repeats protein isoform X9

  18. XM_073938973.1 → XP_073795074.1  arginine-glutamic acid dipeptide repeats protein isoform X12

  19. XM_073938972.1 → XP_073795073.1  arginine-glutamic acid dipeptide repeats protein isoform X11

RNA

  1. XR_012398487.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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