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THAP10 THAP domain containing 10 [ Homo sapiens (human) ]

Gene ID: 56906, updated on 25-Jan-2022

Summary

Official Symbol
THAP10provided by HGNC
Official Full Name
THAP domain containing 10provided by HGNC
Primary source
HGNC:HGNC:23193
See related
Ensembl:ENSG00000129028 MIM:612538; AllianceGenome:HGNC:23193
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of a family of proteins sharing an N-terminal Thanatos-associated domain. The Thanatos-associated domain contains a zinc finger signature similar to DNA-binding domains. This gene is part of a bidirectional gene pair on the long arm of chromosome 15 that is regulated by estrogen and may play a role in breast cancer. [provided by RefSeq, Nov 2010]
Expression
Ubiquitous expression in brain (RPKM 3.1), thyroid (RPKM 2.1) and 24 other tissues See more
Orthologs
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Genomic context

See THAP10 in Genome Data Viewer
Location:
15q23
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (70881342..70892433, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (71173681..71184772, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene La ribonucleoprotein 6, translational regulator Neighboring gene leucine rich repeat containing 49 Neighboring gene keratin 8 pseudogene 9 Neighboring gene ribosomal protein L5 pseudogene 3 Neighboring gene uncharacterized LOC105370886

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
THAP domain-containing protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020147.4NP_064532.1  THAP domain-containing protein 10

    See identical proteins and their annotated locations for NP_064532.1

    Status: REVIEWED

    Source sequence(s)
    AC090868, BC027857, DA272000
    Consensus CDS
    CCDS10237.1
    UniProtKB/Swiss-Prot
    Q9P2Z0
    Related
    ENSP00000249861.4, ENST00000249861.9
    Conserved Domains (1) summary
    smart00980
    Location:490
    THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    70881342..70892433 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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