U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

foxp1b forkhead box P1b [ Danio rerio (zebrafish) ]

Gene ID: 569047, updated on 9-Sep-2025
Official Symbol
foxp1bprovided by ZNC
Official Full Name
forkhead box P1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041203-1
See related
Ensembl:ENSDARG00000014181 AllianceGenome:ZFIN:ZDB-GENE-041203-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
foxp1; im:7139058; wu:fc83a06
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including gut; hatching gland; nervous system; pericardial region; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including Barrett's esophagus; congenital heart disease; esophagus adenocarcinoma; intellectual disability-severe speech delay-mild dysmorphism syndrome; and peritonitis. Orthologous to human FOXP1 (forkhead box P1). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table
See foxp1b in Genome Data Viewer
Location:
chromosome: 6
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 6 NC_133181.1 (46118978..46410143, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 6 NC_007117.7 (43598677..43890857, complement)

Chromosome 6 - NC_133181.1Genomic Context describing neighboring genes Neighboring gene zgc:113054 Neighboring gene uncharacterized LOC141386340 Neighboring gene MyoD family inhibitor domain containing 2 Neighboring gene uncharacterized LOC141386344 Neighboring gene uncharacterized LOC141386343 Neighboring gene G protein-coupled receptor 27 Neighboring gene prokineticin 2

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Molecular cloning, characterization, and developmental expression of foxp1 in zebrafish. Cheng L, et al. Dev Genes Evol, 2007 Oct. PMID 17876603
  2. FOXP1 potentiates Wnt/β-catenin signaling in diffuse large B cell lymphoma. Walker MP, et al. Sci Signal, 2015 Feb 3. PMID 25650440, Free PMC Article
  3. The Fox gene family in Xenopus laevis:FoxI2, FoxM1 and FoxP1 in early development. Pohl BS, et al. Int J Dev Biol, 2005. PMID 15744668
  4. Differential evolution of duplicated medakafish mitf genes. Li M, et al. Int J Biol Sci, 2013. PMID 23781143, Free PMC Article
  5. Biochemical characterization of Prokineticin 2 binding to Prokineticin receptor 1 in zebrafish. Lattanzi R, et al. Neuropeptides, 2024 Oct. PMID 39089191

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Foxp and Skor family proteins control differentiation of Purkinje cells from Ptf1a- and Neurog1-expressing progenitors in zebrafish.
    Title: Foxp and Skor family proteins control differentiation of Purkinje cells from Ptf1a- and Neurog1-expressing progenitors in zebrafish.
  2. Prominent foxp1 expression is detected in many regions of the developing central nervous system, especially in midbrain-hindbrain boundary, hindbrain, and spinal cord.
    Title: Molecular cloning, characterization, and developmental expression of foxp1 in zebrafish.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
forkhead box protein P1-B
Names
forkhead box P1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039637.1 → NP_001034726.1  forkhead box protein P1-B

    See identical proteins and their annotated locations for NP_001034726.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ333303
    UniProtKB/Swiss-Prot
    Q2LE08
    UniProtKB/TrEMBL
    A0A8M3ATJ4
    Related
    ENSDARP00000064937.3, ENSDART00000064938.5
    Conserved Domains (2) summary
    pfam00250
    Location:448 → 521
    Forkhead; Forkhead domain
    pfam16159
    Location:285 → 352
    FOXP-CC; FOXP coiled-coil domain

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133181.1 Reference GRCz12tu Primary Assembly

    Range
    46118978..46410143 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073953183.1 → XP_073809284.1  forkhead box protein P1-B isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q673

  2. XM_073953198.1 → XP_073809299.1  forkhead box protein P1-B isoform X3

    UniProtKB/TrEMBL
    A0A8M3ATJ4, A0A8M9PZW2

  3. XM_073953191.1 → XP_073809292.1  forkhead box protein P1-B isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q673

  4. XM_073953197.1 → XP_073809298.1  forkhead box protein P1-B isoform X2

  5. XM_073953203.1 → XP_073809304.1  forkhead box protein P1-B isoform X4

    UniProtKB/TrEMBL
    A0A8M3ATJ4, A0AB32TWY7

  6. XM_073953181.1 → XP_073809282.1  forkhead box protein P1-B isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q673

  7. XM_068221767.2 → XP_068077868.1  forkhead box protein P1-B isoform X3

    UniProtKB/TrEMBL
    A0A8M3ATJ4, A0A8M9PZW2

  8. XM_073953194.1 → XP_073809295.1  forkhead box protein P1-B isoform X2

  9. XM_073953206.1 → XP_073809307.1  forkhead box protein P1-B isoform X4

    UniProtKB/TrEMBL
    A0A8M3ATJ4, A0AB32TWY7

  10. XM_073953185.1 → XP_073809286.1  forkhead box protein P1-B isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q673

  11. XM_073953200.1 → XP_073809301.1  forkhead box protein P1-B isoform X3

    UniProtKB/TrEMBL
    A0A8M3ATJ4, A0A8M9PZW2

  12. XM_073953192.1 → XP_073809293.1  forkhead box protein P1-B isoform X2

  13. XM_073953204.1 → XP_073809305.1  forkhead box protein P1-B isoform X4

    UniProtKB/TrEMBL
    A0A8M3ATJ4, A0AB32TWY7

  14. XM_073953182.1 → XP_073809283.1  forkhead box protein P1-B isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q673

  15. XM_068221770.2 → XP_068077871.1  forkhead box protein P1-B isoform X3

    UniProtKB/TrEMBL
    A0A8M3ATJ4, A0A8M9PZW2

  16. XM_073953199.1 → XP_073809300.1  forkhead box protein P1-B isoform X3

    UniProtKB/TrEMBL
    A0A8M3ATJ4, A0A8M9PZW2

  17. XM_073953190.1 → XP_073809291.1  forkhead box protein P1-B isoform X2

  18. XM_068221776.2 → XP_068077877.1  forkhead box protein P1-B isoform X4

    UniProtKB/TrEMBL
    A0A8M3ATJ4, A0AB32TWY7

  19. XM_073953177.1 → XP_073809278.1  forkhead box protein P1-B isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q673

  20. XM_068221769.2 → XP_068077870.1  forkhead box protein P1-B isoform X3

    UniProtKB/TrEMBL
    A0A8M3ATJ4, A0A8M9PZW2

  21. XM_073953196.1 → XP_073809297.1  forkhead box protein P1-B isoform X2

  22. XM_073953202.1 → XP_073809303.1  forkhead box protein P1-B isoform X4

    UniProtKB/TrEMBL
    A0A8M3ATJ4, A0AB32TWY7

  23. XM_073953179.1 → XP_073809280.1  forkhead box protein P1-B isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q673

  24. XM_068221771.2 → XP_068077872.1  forkhead box protein P1-B isoform X3

    UniProtKB/TrEMBL
    A0A8M3ATJ4, A0A8M9PZW2

  25. XM_073953189.1 → XP_073809290.1  forkhead box protein P1-B isoform X2

  26. XM_068221775.2 → XP_068077876.1  forkhead box protein P1-B isoform X4

    UniProtKB/TrEMBL
    A0A8M3ATJ4, A0AB32TWY7

  27. XM_005166055.6 → XP_005166112.1  forkhead box protein P1-B isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q673
    Conserved Domains (2) summary
    cd00059
    Location:449 → 521
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:286 → 353
    FOXP-CC; FOXP coiled-coil domain

  28. XM_068221766.2 → XP_068077867.1  forkhead box protein P1-B isoform X3

    UniProtKB/TrEMBL
    A0A8M3ATJ4, A0A8M9PZW2

  29. XM_073953201.1 → XP_073809302.1  forkhead box protein P1-B isoform X4

    UniProtKB/TrEMBL
    A0A8M3ATJ4, A0AB32TWY7

  30. XM_073953178.1 → XP_073809279.1  forkhead box protein P1-B isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q673

  31. XM_068221768.2 → XP_068077869.1  forkhead box protein P1-B isoform X3

    UniProtKB/TrEMBL
    A0A8M3ATJ4, A0A8M9PZW2

  32. XM_073953193.1 → XP_073809294.1  forkhead box protein P1-B isoform X2

  33. XM_073953205.1 → XP_073809306.1  forkhead box protein P1-B isoform X4

    UniProtKB/TrEMBL
    A0A8M3ATJ4, A0AB32TWY7

  34. XM_073953184.1 → XP_073809285.1  forkhead box protein P1-B isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q673

  35. XM_068221772.2 → XP_068077873.1  forkhead box protein P1-B isoform X3

    UniProtKB/TrEMBL
    A0A8M3ATJ4, A0A8M9PZW2
    Related
    ENSDARP00000154863.1

  36. XM_073953195.1 → XP_073809296.1  forkhead box protein P1-B isoform X2

  37. XM_073953207.1 → XP_073809308.1  forkhead box protein P1-B isoform X4

    UniProtKB/TrEMBL
    A0A8M3ATJ4, A0AB32TWY7

  38. XM_073953186.1 → XP_073809287.1  forkhead box protein P1-B isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q673

  39. XM_021476918.3 → XP_021332593.1  forkhead box protein P1-B isoform X3

    UniProtKB/TrEMBL
    A0A8M3ATJ4, A0A8M9PZW2
    Related
    ENSDARP00000156823.1
    Conserved Domains (2) summary
    cd00059
    Location:449 → 521
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:286 → 353
    FOXP-CC; FOXP coiled-coil domain

  40. XM_073953188.1 → XP_073809289.1  forkhead box protein P1-B isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q673

  41. XM_068221774.2 → XP_068077875.1  forkhead box protein P1-B isoform X3

    UniProtKB/TrEMBL
    A0A8M3ATJ4, A0A8M9PZW2
    Related
    ENSDARP00000109350.1

  42. XM_073953208.1 → XP_073809309.1  forkhead box protein P1-B isoform X4

    UniProtKB/TrEMBL
    A0A8M3ATJ4, A0AB32TWY7

  43. XM_073953187.1 → XP_073809288.1  forkhead box protein P1-B isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q673

  44. XM_068221773.2 → XP_068077874.1  forkhead box protein P1-B isoform X3

    UniProtKB/TrEMBL
    A0A8M3ATJ4, A0A8M9PZW2

  45. XM_073953210.1 → XP_073809311.1  forkhead box protein P1-B isoform X6

  46. XM_073953212.1 → XP_073809313.1  forkhead box protein P1-B isoform X8

  47. XM_073953209.1 → XP_073809310.1  forkhead box protein P1-B isoform X5

  48. XM_073953211.1 → XP_073809312.1  forkhead box protein P1-B isoform X7

RNA

  1. XR_012407405.1 RNA Sequence

  2. XR_012407404.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2LE08.1 GenPept UniProtKB/Swiss-Prot:Q2LE08

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools