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PAPOLB poly(A) polymerase beta [ Homo sapiens (human) ]

Gene ID: 56903, updated on 18-Aug-2020

Summary

Official Symbol
PAPOLBprovided by HGNC
Official Full Name
poly(A) polymerase betaprovided by HGNC
Primary source
HGNC:HGNC:15970
See related
Ensembl:ENSG00000218823 MIM:607436
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAPT; TPAP
Orthologs

Genomic context

See PAPOLB in Genome Data Viewer
Location:
7p22.1
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (4857738..4862030, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (4897369..4901625, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene adaptor related protein complex 5 subunit zeta 1 Neighboring gene microRNA 4656 Neighboring gene Rap associating with DIL domain Neighboring gene small nucleolar RNA, C/D box 165 Neighboring gene ribosomal protein L22 pseudogene 16 Neighboring gene Sharpr-MPRA regulatory region 4159

Genomic regions, transcripts, and products

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat The poly(A) site in the HIV-1 5'-LTR is occluded in a Tat-dependent manner, suggesting a role for Tat in regulating this nucleotide signal PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
polynucleotide adenylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
mRNA polyadenylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
poly(A) polymerase beta
Names
PAP-beta
poly(A) polymerase beta (testis specific)
polynucleotide adenylyltransferase beta
testis-specific poly(A) polymerase
NP_064529.4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020144.5NP_064529.4  poly(A) polymerase beta

    See identical proteins and their annotated locations for NP_064529.4

    Status: VALIDATED

    Source sequence(s)
    AC092610, AF218840, BC036653
    Consensus CDS
    CCDS78202.1
    UniProtKB/Swiss-Prot
    Q9NRJ5
    UniProtKB/TrEMBL
    A4D1Z6
    Related
    ENSP00000384700.2, ENST00000404991.2
    Conserved Domains (3) summary
    PTZ00418
    Location:21569
    PTZ00418; Poly(A) polymerase; Provisional
    pfam04926
    Location:367496
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:22364
    PAP_central; Poly(A) polymerase central domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    4857738..4862030 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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