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map2k4b mitogen-activated protein kinase kinase 4b [ Danio rerio (zebrafish) ]

Gene ID: 568951, updated on 13-Jun-2020

Summary

Official Symbol
map2k4bprovided by ZNC
Official Full Name
mitogen-activated protein kinase kinase 4bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-080721-13
See related
Ensembl:ENSDARG00000077177
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
MKK4B; zgc:194486
Orthologs

Genomic context

See map2k4b in Genome Data Viewer
Location:
chromosome: 12
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (280137..287821, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (83262..90270, complement)
103 previous assembly Zv9 (GCF_000002035.4) 12 NC_007123.5 (12606..19612)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene myosin-16-like Neighboring gene growth arrest-specific 7b Neighboring gene uncharacterized LOC103910607 Neighboring gene growth arrest-specific protein 7-like Neighboring gene ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent

Genomic regions, transcripts, and products

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
JUN kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MAP kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
activation of JUN kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of MAPK activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
convergent extension involved in gastrulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dual specificity mitogen-activated protein kinase kinase 4; dual specificity mitogen-activated protein kinase kinase 4b
Names
MAP kinase kinase 4B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001089421.1NP_001082890.1  dual specificity mitogen-activated protein kinase kinase 4b

    See identical proteins and their annotated locations for NP_001082890.1

    Status: PROVISIONAL

    Source sequence(s)
    EF489398
    UniProtKB/TrEMBL
    A4UU31
    Related
    ENSDARP00000101456.2, ENSDART00000113335.4
    Conserved Domains (2) summary
    smart00220
    Location:121385
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06616
    Location:114403
    PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    280137..287821 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021480156.1XP_021335831.1  dual specificity mitogen-activated protein kinase kinase 4 isoform X2

    Conserved Domains (1) summary
    cd06616
    Location:179476
    PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4
  2. XM_021480155.1XP_021335830.1  dual specificity mitogen-activated protein kinase kinase 4 isoform X1

    Conserved Domains (1) summary
    cd06616
    Location:190487
    PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4
  3. XM_005172951.4XP_005173008.1  dual specificity mitogen-activated protein kinase kinase 4 isoform X3

    Conserved Domains (2) summary
    smart00220
    Location:186450
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06616
    Location:179468
    PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4
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