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FSTL5 follistatin like 5 [ Homo sapiens (human) ]

Gene ID: 56884, updated on 22-Aug-2020

Summary

Official Symbol
FSTL5provided by HGNC
Official Full Name
follistatin like 5provided by HGNC
Primary source
HGNC:HGNC:21386
See related
Ensembl:ENSG00000168843
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in brain (RPKM 6.2), adrenal (RPKM 3.7) and 1 other tissue See more
Orthologs

Genomic context

See FSTL5 in Genome Data Viewer
Location:
4q32.2
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (161383897..162164000, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (162305044..163085186, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377514 Neighboring gene uncharacterized LOC105377515 Neighboring gene uncharacterized LOC101928052 Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase pseudogene 4 Neighboring gene TOMM22 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A novel colorectal cancer risk locus at 4q32.2 identified from an international genome-wide association study.
GeneReviews: Not available
Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1263, DKFZp566D234

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
follistatin-related protein 5
Names
follistatin-like protein 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128427.3NP_001121899.1  follistatin-related protein 5 isoform b precursor

    See identical proteins and their annotated locations for NP_001121899.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AA350666, AB033089, BI549596, DA243182
    Consensus CDS
    CCDS47158.1
    UniProtKB/Swiss-Prot
    Q8N475
    Related
    ENSP00000368462.4, ENST00000379164.8
    Conserved Domains (8) summary
    cd05736
    Location:357432
    Ig2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a follistatin-like molecule encoded by the Mahya gene and similar proteins
    smart00408
    Location:262324
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:259338
    IG_like; Immunoglobulin like
    COG3391
    Location:505733
    YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
    cd00104
    Location:92132
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam07679
    Location:340429
    I-set; Immunoglobulin I-set domain
    pfam13499
    Location:181241
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:179242
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  2. NM_001128428.3NP_001121900.1  follistatin-related protein 5 isoform c precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site and lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AA350666, AB033089, AK315152, BI549596, DA243182
    Consensus CDS
    CCDS47157.1
    UniProtKB/Swiss-Prot
    Q8N475
    Related
    ENSP00000389270.2, ENST00000427802.2
    Conserved Domains (8) summary
    cd05736
    Location:357432
    Ig2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a follistatin-like molecule encoded by the Mahya gene and similar proteins
    smart00408
    Location:262324
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:259338
    IG_like; Immunoglobulin like
    COG3391
    Location:496724
    YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
    cd00104
    Location:92132
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam07679
    Location:340429
    I-set; Immunoglobulin I-set domain
    pfam13499
    Location:181241
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:179242
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  3. NM_020116.5NP_064501.2  follistatin-related protein 5 isoform a precursor

    See identical proteins and their annotated locations for NP_064501.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AA350666, AB033089, BC036502, BI549596, DA243182
    Consensus CDS
    CCDS3802.1
    UniProtKB/Swiss-Prot
    Q8N475
    Related
    ENSP00000305334.4, ENST00000306100.10
    Conserved Domains (8) summary
    cd05736
    Location:358433
    Ig2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a follistatin-like molecule encoded by the Mahya gene and similar proteins
    smart00408
    Location:263325
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:260339
    IG_like; Immunoglobulin like
    COG3391
    Location:506734
    YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
    cd00104
    Location:93133
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam07679
    Location:341430
    I-set; Immunoglobulin I-set domain
    pfam13499
    Location:182242
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:180243
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    161383897..162164000 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532126.1XP_011530428.1  follistatin-related protein 5 isoform X1

    Conserved Domains (8) summary
    cd05736
    Location:358433
    Ig2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a follistatin-like molecule encoded by the Mahya gene and similar proteins
    smart00408
    Location:263325
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:260339
    IG_like; Immunoglobulin like
    COG3391
    Location:497725
    YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
    cd00104
    Location:93133
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam07679
    Location:341430
    I-set; Immunoglobulin I-set domain
    pfam13499
    Location:182242
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:180243
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
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