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CDC42SE1 CDC42 small effector 1 [ Homo sapiens (human) ]

Gene ID: 56882, updated on 21-Dec-2019

Summary

Official Symbol
CDC42SE1provided by HGNC
Official Full Name
CDC42 small effector 1provided by HGNC
Primary source
HGNC:HGNC:17719
See related
Ensembl:ENSG00000197622
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCIP1; SPEC1
Expression
Ubiquitous expression in spleen (RPKM 61.6), lymph node (RPKM 60.7) and 25 other tissues See more
Orthologs

Genomic context

See CDC42SE1 in Genome Data Viewer
Location:
1q21.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (151050971..151059649, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151023447..151032125, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene prune exopolyphosphatase 1 Neighboring gene RNA, U6 small nuclear 884, pseudogene Neighboring gene BCL2 interacting protein like Neighboring gene chromosome 1 open reading frame 56 Neighboring gene MLLT11 transcription factor 7 cofactor Neighboring gene GA binding protein transcription factor subunit beta 2 Neighboring gene ribosomal protein S29 pseudogene 29

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
Rho GTPase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
phagocytosis IEA
Inferred from Electronic Annotation
more info
 
regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell junction IDA
Inferred from Direct Assay
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
CDC42 small effector protein 1
Names
1300002M12Rik
CDC42-binding protein SCIP1
signaling molecule SPEC1 beta
small effector of CDC42 protein 1
small protein effector 1 of Cdc42

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038707.1NP_001033796.1  CDC42 small effector protein 1

    See identical proteins and their annotated locations for NP_001033796.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL590133, BC012796, BP340339, BX339337
    Consensus CDS
    CCDS981.1
    UniProtKB/Swiss-Prot
    Q9NRR8
    Related
    ENSP00000445647.1, ENST00000540998.5
    Conserved Domains (1) summary
    cl00113
    Location:2967
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
  2. NM_020239.4NP_064624.1  CDC42 small effector protein 1

    See identical proteins and their annotated locations for NP_064624.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL590133, BC012796, BP340339
    Consensus CDS
    CCDS981.1
    UniProtKB/Swiss-Prot
    Q9NRR8
    Related
    ENSP00000349773.4, ENST00000357235.6
    Conserved Domains (1) summary
    cl00113
    Location:2967
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    151050971..151059649 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001847.2XP_016857336.1  CDC42 small effector protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9NRR8
    Conserved Domains (1) summary
    cl00113
    Location:2967
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
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