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ntrk3a neurotrophic tyrosine kinase, receptor, type 3a [ Danio rerio (zebrafish) ]

Gene ID: 568668, updated on 4-Nov-2022

Summary

Official Symbol
ntrk3aprovided by ZNC
Official Full Name
neurotrophic tyrosine kinase, receptor, type 3aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-010126-3
See related
Ensembl:ENSDARG00000077228 AllianceGenome:ZFIN:ZDB-GENE-010126-3
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
trkC1
Summary
Predicted to enable neurotrophin binding activity; neurotrophin receptor activity; and transmembrane receptor protein tyrosine kinase activity. Acts upstream of or within central nervous system development and negative regulation of apoptotic process. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in axon. Predicted to be integral component of plasma membrane. Is expressed in nervous system and otic vesicle. Human ortholog(s) of this gene implicated in adenoid cystic carcinoma; colorectal cancer; and stomach cancer. Orthologous to human NTRK3 (neurotrophic receptor tyrosine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See ntrk3a in Genome Data Viewer
Location:
chromosome: 25
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (11805540..12203961, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (11706542..12107456, complement)
103 previous assembly Zv9 (GCF_000002035.4) 25 NC_007136.5 (12143566..12538848, complement)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene kelch like family member 25 Neighboring gene ATP/GTP binding protein like 1 Neighboring gene uncharacterized LOC110438380 Neighboring gene uncharacterized LOC103909826 Neighboring gene DET1 partner of COP1 E3 ubiquitin ligase Neighboring gene microRNA 7a-1

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables neurotrophin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables neurotrophin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to nerve growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within central nervous system development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
NOT involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of protein kinase B signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within transmembrane receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
NT-3 growth factor receptor
NP_001243593.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256664.2NP_001243593.1  NT-3 growth factor receptor precursor

    Status: VALIDATED

    Source sequence(s)
    BX088695, CR352216, CU076078, CU855793, FQ311882
    UniProtKB/TrEMBL
    A0A8M1P2M2, F1QKJ0, G9JKB3
    Related
    ENSDARP00000086160.5, ENSDART00000091727.6
    Conserved Domains (8) summary
    cd04972
    Location:208298
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00221
    Location:531803
    STYKc; Protein kinase; unclassified specificity
    pfam07679
    Location:207298
    I-set; Immunoglobulin I-set domain
    cd05094
    Location:525811
    PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
    sd00031
    Location:103126
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:101157
    LRR_8; Leucine rich repeat
    pfam16920
    Location:161205
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cl11960
    Location:316393
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    11805540..12203961 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395189.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    81509..167234 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)