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kcnma1a potassium large conductance calcium-activated channel, subfamily M, alpha member 1a [ Danio rerio (zebrafish) ]

Gene ID: 568554, updated on 4-Feb-2026
Official Symbol
kcnma1aprovided by ZNC
Official Full Name
potassium large conductance calcium-activated channel, subfamily M, alpha member 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070202-9
See related
Ensembl:ENSDARG00000079840 AllianceGenome:ZFIN:ZDB-GENE-070202-9
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
kcnma1; si:ch211-39f22.2
Summary
Enables calcium ion binding activity and calcium-activated potassium channel activity. Involved in potassium ion transmembrane transport. Acts upstream of or within response to auditory stimulus. Located in membrane. Is expressed in several structures, including brain; otic vesicle; pectoral fin bud; peripheral olfactory organ; and presumptive diencephalon. Human ortholog(s) of this gene implicated in Alzheimer's disease; generalized epilepsy; and paroxysmal nonkinesigenic dyskinesia 3. Orthologous to human KCNMA1 (potassium calcium-activated channel subfamily M alpha 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See kcnma1a in Genome Data Viewer
Location:
chromosome: 13
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 13 NC_133188.1 (18504202..18872571)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 13 NC_007124.7 (16521969..16889105)

Chromosome 13 - NC_133188.1Genomic Context describing neighboring genes Neighboring gene discs, large homolog 5a (Drosophila) Neighboring gene uncharacterized LOC141376998 Neighboring gene uncharacterized LOC141375027 Neighboring gene leucine rich melanocyte differentiation associated Neighboring gene uncharacterized LOC141377001

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Open structure of the Ca2+ gating ring in the high-conductance Ca2+-activated K+ channel. Yuan P, et al. Nature, 2011 Dec 4. PMID 22139424, Free PMC Article
  2. Manipulation of BK channel expression is sufficient to alter auditory hair cell thresholds in larval zebrafish. Rohmann KN, et al. J Exp Biol, 2014 Jul 15. PMID 24803460, Free PMC Article
  3. Conserved Role of the Large Conductance Calcium-Activated Potassium Channel, K(Ca)1.1, in Sinus Node Function and Arrhythmia Risk. Pineda S, et al. Circ Genom Precis Med, 2021 Apr. PMID 33629867, Free PMC Article
  4. Ion channel gene expression in the inner ear. Gabashvili IS, et al. J Assoc Res Otolaryngol, 2007 Sep. PMID 17541769, Free PMC Article
  5. Diversity of Ca2+-activated K+ channel transcripts in inner ear hair cells. Beisel KW, et al. Gene, 2007 Jan 15. PMID 17097837

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium-activated potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables large conductance calcium-activated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to auditory stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
calcium-activated potassium channel subunit alpha-1a
Names
BK channel
large conductance calcium-activated potassium (BK) channel alpha subunit a
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
slo1a
slowpoke homolog

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145600.1 → NP_001139072.1  calcium-activated potassium channel subunit alpha-1a

    Status: PROVISIONAL

    Source sequence(s)
    JBMGRA010000013
    UniProtKB/Swiss-Prot
    A0A8M1NRK6, B7ZC96
    UniProtKB/TrEMBL
    A0AB32T574
    Related
    ENSDARP00000118939.1, ENSDART00000143200.2
    Conserved Domains (4) summary
    pfam00520
    Location:164 → 350
    Ion_trans; Ion transport protein
    pfam03493
    Location:499 → 587
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:260 → 345
    Ion_trans_2; Ion channel
    cl21454
    Location:364 → 477
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133188.1 Reference GRCz12tu Primary Assembly

    Range
    18504202..18872571
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073919866.1 → XP_073775967.1  calcium-activated potassium channel subunit alpha-1a isoform X40

  2. XM_073919869.1 → XP_073775970.1  calcium-activated potassium channel subunit alpha-1a isoform X43

  3. XM_073919863.1 → XP_073775964.1  calcium-activated potassium channel subunit alpha-1a isoform X38

  4. XM_073919867.1 → XP_073775968.1  calcium-activated potassium channel subunit alpha-1a isoform X41

  5. XM_073919870.1 → XP_073775971.1  calcium-activated potassium channel subunit alpha-1a isoform X44

  6. XM_009307243.5 → XP_009305518.1  calcium-activated potassium channel subunit alpha-1a isoform X1

    UniProtKB/TrEMBL
    A0A8M3B7Y4, A0AB32T290
    Conserved Domains (4) summary
    pfam00520
    Location:181 → 367
    Ion_trans; Ion transport protein
    pfam03493
    Location:516 → 604
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:277 → 362
    Ion_trans_2; Ion channel
    cl21454
    Location:381 → 494
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  7. XM_073919846.1 → XP_073775947.1  calcium-activated potassium channel subunit alpha-1a isoform X9

    UniProtKB/TrEMBL
    A0A8M6Z968

  8. XM_073919843.1 → XP_073775944.1  calcium-activated potassium channel subunit alpha-1a isoform X4

    UniProtKB/TrEMBL
    A0AB32T290

  9. XM_073919851.1 → XP_073775952.1  calcium-activated potassium channel subunit alpha-1a isoform X17

    UniProtKB/TrEMBL
    A0A8M6Z968

  10. XM_068212907.2 → XP_068069008.1  calcium-activated potassium channel subunit alpha-1a isoform X2

    UniProtKB/TrEMBL
    A0AB32T1I2, A0AB32T290

  11. XM_073919848.1 → XP_073775949.1  calcium-activated potassium channel subunit alpha-1a isoform X12

    UniProtKB/TrEMBL
    A0A8M6Z968

  12. XM_009307246.5 → XP_009305521.1  calcium-activated potassium channel subunit alpha-1a isoform X5

    UniProtKB/TrEMBL
    A0A8M3BEL0, A0AB32T290
    Conserved Domains (4) summary
    pfam00520
    Location:181 → 367
    Ion_trans; Ion transport protein
    pfam03493
    Location:516 → 604
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:277 → 362
    Ion_trans_2; Ion channel
    cl21454
    Location:381 → 494
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  13. XM_005156667.6 → XP_005156724.1  calcium-activated potassium channel subunit alpha-1a isoform X19

    UniProtKB/TrEMBL
    A0A8M2B3K4, A0A8M6Z968
    Conserved Domains (4) summary
    pfam00520
    Location:181 → 367
    Ion_trans; Ion transport protein
    pfam03493
    Location:516 → 604
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:277 → 362
    Ion_trans_2; Ion channel
    cl21454
    Location:381 → 494
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  14. XM_021480635.3 → XP_021336310.1  calcium-activated potassium channel subunit alpha-1a isoform X10

    UniProtKB/TrEMBL
    A0A8M9QNH1, A0AB32T290
    Conserved Domains (3) summary
    pfam00520
    Location:150 → 367
    Ion_trans; Ion transport protein
    pfam03493
    Location:516 → 604
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl26838
    Location:314 → 474
    Ion_trans; Ion transport protein

  15. XM_073919859.1 → XP_073775960.1  calcium-activated potassium channel subunit alpha-1a isoform X31

    UniProtKB/TrEMBL
    A0A8M6Z968

  16. XM_005156663.6 → XP_005156720.1  calcium-activated potassium channel subunit alpha-1a isoform X14

    UniProtKB/TrEMBL
    A0A8M2B2Q5, A0AB32T290
    Conserved Domains (4) summary
    pfam00520
    Location:181 → 367
    Ion_trans; Ion transport protein
    pfam03493
    Location:516 → 604
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:277 → 362
    Ion_trans_2; Ion channel
    cl21454
    Location:381 → 494
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  17. XM_017358781.4 → XP_017214270.1  calcium-activated potassium channel subunit alpha-1a isoform X27

    UniProtKB/TrEMBL
    A0A8M6Z1R0, A0A8M6Z968

  18. XM_005156670.6 → XP_005156727.1  calcium-activated potassium channel subunit alpha-1a isoform X21

    UniProtKB/TrEMBL
    A0A8M2B2T7, A0AB32T290, F1QYL4
    Related
    ENSDARP00000105964.3
    Conserved Domains (4) summary
    pfam00520
    Location:181 → 367
    Ion_trans; Ion transport protein
    pfam03493
    Location:516 → 604
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:277 → 362
    Ion_trans_2; Ion channel
    cl21454
    Location:381 → 494
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  19. XM_017358783.4 → XP_017214272.1  calcium-activated potassium channel subunit alpha-1a isoform X34

    UniProtKB/TrEMBL
    A0A8M6Z2C3, A0A8M6Z968

  20. XM_073919844.1 → XP_073775945.1  calcium-activated potassium channel subunit alpha-1a isoform X6

    UniProtKB/TrEMBL
    A0AB32T574

  21. XM_073919845.1 → XP_073775946.1  calcium-activated potassium channel subunit alpha-1a isoform X8

    UniProtKB/TrEMBL
    A0AB32T574

  22. XM_073919854.1 → XP_073775955.1  calcium-activated potassium channel subunit alpha-1a isoform X25

    UniProtKB/TrEMBL
    A0A8M6Z968

  23. XM_005156659.6 → XP_005156716.1  calcium-activated potassium channel subunit alpha-1a isoform X7

    UniProtKB/TrEMBL
    A0A8M2B3J8, A0AB32T574
    Conserved Domains (4) summary
    pfam00520
    Location:181 → 367
    Ion_trans; Ion transport protein
    pfam03493
    Location:516 → 604
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:277 → 362
    Ion_trans_2; Ion channel
    cl21454
    Location:381 → 494
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  24. XM_005156669.6 → XP_005156726.1  calcium-activated potassium channel subunit alpha-1a isoform X20

    UniProtKB/TrEMBL
    A0A8M2B2Q8, A0A8M6Z968
    Conserved Domains (4) summary
    pfam00520
    Location:181 → 367
    Ion_trans; Ion transport protein
    pfam03493
    Location:516 → 604
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:277 → 362
    Ion_trans_2; Ion channel
    cl21454
    Location:381 → 494
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  25. XM_073919847.1 → XP_073775948.1  calcium-activated potassium channel subunit alpha-1a isoform X11

    UniProtKB/TrEMBL
    A0AB32T574

  26. XM_073919855.1 → XP_073775956.1  calcium-activated potassium channel subunit alpha-1a isoform X26

    UniProtKB/TrEMBL
    A0A8M6Z968

  27. XM_073919852.1 → XP_073775953.1  calcium-activated potassium channel subunit alpha-1a isoform X18

    UniProtKB/TrEMBL
    A0AB32T574

  28. XM_073919860.1 → XP_073775961.1  calcium-activated potassium channel subunit alpha-1a isoform X32

    UniProtKB/TrEMBL
    A0A8M6Z968

  29. XM_073919842.1 → XP_073775943.1  calcium-activated potassium channel subunit alpha-1a isoform X3

    UniProtKB/TrEMBL
    A0AB32T574

  30. XM_073919849.1 → XP_073775950.1  calcium-activated potassium channel subunit alpha-1a isoform X13

    UniProtKB/TrEMBL
    A0A8M6Z968

  31. XM_005156665.6 → XP_005156722.1  calcium-activated potassium channel subunit alpha-1a isoform X15

    UniProtKB/TrEMBL
    A0A2R8QRZ7, A0A8M2B2Z8, A0AB32T574
    Related
    ENSDARP00000155995.1
    Conserved Domains (4) summary
    pfam00520
    Location:181 → 367
    Ion_trans; Ion transport protein
    pfam03493
    Location:516 → 604
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:277 → 362
    Ion_trans_2; Ion channel
    cl21454
    Location:381 → 494
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  32. XM_073919856.1 → XP_073775957.1  calcium-activated potassium channel subunit alpha-1a isoform X28

    UniProtKB/TrEMBL
    A0A8M6Z968

  33. XM_017358785.4 → XP_017214274.1  calcium-activated potassium channel subunit alpha-1a isoform X35

    UniProtKB/TrEMBL
    A0A8M6Z968, A0A8M6Z9M0

  34. XM_021480639.3 → XP_021336314.1  calcium-activated potassium channel subunit alpha-1a isoform X22

    UniProtKB/TrEMBL
    A0A8M9QFI6, A0AB32T0L3
    Conserved Domains (3) summary
    pfam00520
    Location:150 → 358
    Ion_trans; Ion transport protein
    pfam03493
    Location:516 → 604
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:381 → 494
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  35. XM_073919853.1 → XP_073775954.1  calcium-activated potassium channel subunit alpha-1a isoform X23

    UniProtKB/TrEMBL
    A0AB32T0L3

  36. XM_073919857.1 → XP_073775958.1  calcium-activated potassium channel subunit alpha-1a isoform X29

    UniProtKB/TrEMBL
    A0AB32T0L3

  37. XM_073919861.1 → XP_073775962.1  calcium-activated potassium channel subunit alpha-1a isoform X33

    UniProtKB/TrEMBL
    A0A8M6Z968

  38. XM_073919850.1 → XP_073775951.1  calcium-activated potassium channel subunit alpha-1a isoform X16

    UniProtKB/TrEMBL
    A0AB32T0L3

  39. XM_073919858.1 → XP_073775959.1  calcium-activated potassium channel subunit alpha-1a isoform X30

    UniProtKB/TrEMBL
    A0A8M6Z968

  40. XM_021480641.3 → XP_021336316.1  calcium-activated potassium channel subunit alpha-1a isoform X24

    UniProtKB/TrEMBL
    A0A8M9QJS7, A0AB32T0L3
    Conserved Domains (3) summary
    pfam00520
    Location:150 → 358
    Ion_trans; Ion transport protein
    pfam03493
    Location:516 → 604
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:381 → 494
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  41. XM_021480642.3 → XP_021336317.1  calcium-activated potassium channel subunit alpha-1a isoform X36

    UniProtKB/TrEMBL
    A0A8M6Z968, A0A8M9PY23
    Conserved Domains (3) summary
    pfam00520
    Location:150 → 358
    Ion_trans; Ion transport protein
    pfam03493
    Location:516 → 604
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:381 → 494
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  42. XM_073919862.1 → XP_073775963.1  calcium-activated potassium channel subunit alpha-1a isoform X37

  43. XM_073919865.1 → XP_073775966.1  calcium-activated potassium channel subunit alpha-1a isoform X39

  44. XM_073919868.1 → XP_073775969.1  calcium-activated potassium channel subunit alpha-1a isoform X42

  45. XM_073919871.1 → XP_073775972.1  calcium-activated potassium channel subunit alpha-1a isoform X45

RNA

  1. XR_012388642.1 RNA Sequence

  2. XR_012388643.1 RNA Sequence

  3. XR_012388644.1 RNA Sequence

  4. XR_012388641.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B7ZC96.1 GenPept UniProtKB/Swiss-Prot:B7ZC96

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