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GPR137 G protein-coupled receptor 137 [ Homo sapiens (human) ]

Gene ID: 56834, updated on 11-Jun-2021

Summary

Official Symbol
GPR137provided by HGNC
Official Full Name
G protein-coupled receptor 137provided by HGNC
Primary source
HGNC:HGNC:24300
See related
Ensembl:ENSG00000173264
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C11orf4; GPR137A; TM7SF1L1
Expression
Broad expression in testis (RPKM 30.3), brain (RPKM 9.0) and 24 other tissues See more
Orthologs
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Genomic context

See GPR137 in Genome Data Viewer
Location:
11q13.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (64270337..64289500)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64038003..64056972)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene PPP1R14B antisense RNA 1 Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14B Neighboring gene phospholipase C beta 3 Neighboring gene BCL2 associated agonist of cell death Neighboring gene KCNK4-TEX40 readthrough Neighboring gene potassium two pore domain channel subfamily K member 4 Neighboring gene catsper channel auxiliary subunit zeta

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A novel sarcoidosis risk locus for Europeans on chromosome 11q13.1.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of bone resorption IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of osteoclast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
integral membrane protein GPR137
Names
transmembrane 7 superfamily member 1-like 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170880.2NP_001164351.1  integral membrane protein GPR137 isoform 2

    See identical proteins and their annotated locations for NP_001164351.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and contains an alternate in-frame exon in the central coding region compared to variant 1. The encoded protein (isoform 2) is longer, compared to isoform 1. Variants 2 and 8-12 all encode the same isoform (2).
    Source sequence(s)
    AJ250392, AP001453, BC033920, BU730610, BX119209
    Consensus CDS
    CCDS53656.1
    UniProtKB/Swiss-Prot
    Q96N19
    UniProtKB/TrEMBL
    Q9NQC5
    Related
    ENSP00000415698.2, ENST00000438980.7
    Conserved Domains (1) summary
    cd21474
    Location:16325
    7tm_GPR137A; Integral membrane protein GPR137A, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily
  2. NM_001170881.2NP_001164352.1  integral membrane protein GPR137 isoform 1

    See identical proteins and their annotated locations for NP_001164352.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 6, and 7 all encode the same isoform (1).
    Source sequence(s)
    AP001453, BC035002, BI830247
    Consensus CDS
    CCDS53658.1
    UniProtKB/Swiss-Prot
    Q96N19
    Related
    ENSP00000366931.4, ENST00000377702.8
    Conserved Domains (2) summary
    cd21464
    Location:2749
    7tm_GPR137; TM helix 1 [structural motif]
    cl28897
    Location:16275
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  3. NM_001177358.2NP_001170829.1  integral membrane protein GPR137 isoform 5

    See identical proteins and their annotated locations for NP_001170829.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform 5) includes an alternate segment and has a shorter and distinct C-terminus, compared to isoform 1. Variants 5 and 14-16 all encode the same isoform (5).
    Source sequence(s)
    AP001453
    Consensus CDS
    CCDS53657.1
    UniProtKB/Swiss-Prot
    Q96N19
    Related
    ENSP00000442792.1, ENST00000539851.5
    Conserved Domains (2) summary
    cd21464
    Location:2749
    7tm_GPR137; TM helix 1 [structural motif]
    cl28897
    Location:16304
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  4. NM_001378076.1NP_001365005.1  integral membrane protein GPR137 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 1 and 7, encodes isoform 1.
    Source sequence(s)
    AP001453
    Conserved Domains (2) summary
    cd21464
    Location:2749
    7tm_GPR137; TM helix 1 [structural motif]
    cl28897
    Location:16275
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  5. NM_001378077.1NP_001365006.1  integral membrane protein GPR137 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variants 1 and 6, encodes isoform 1.
    Source sequence(s)
    AP001453
    Conserved Domains (2) summary
    cd21464
    Location:2749
    7tm_GPR137; TM helix 1 [structural motif]
    cl28897
    Location:16275
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  6. NM_001378078.1NP_001365007.1  integral membrane protein GPR137 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 2 and 9-12, encodes isoform 2.
    Source sequence(s)
    AP001453
    Conserved Domains (1) summary
    cd21474
    Location:16325
    7tm_GPR137A; Integral membrane protein GPR137A, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily
  7. NM_001378079.1NP_001365008.1  integral membrane protein GPR137 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variants 2, 8, and 10-12, encodes isoform 2.
    Source sequence(s)
    AP001453
    Conserved Domains (1) summary
    cd21474
    Location:16325
    7tm_GPR137A; Integral membrane protein GPR137A, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily
  8. NM_001378080.1NP_001365009.1  integral membrane protein GPR137 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variants 2, 8, 9, 11, and 12, encodes isoform 2.
    Source sequence(s)
    AP001453
    Conserved Domains (1) summary
    cd21474
    Location:16325
    7tm_GPR137A; Integral membrane protein GPR137A, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily
  9. NM_001378081.1NP_001365010.1  integral membrane protein GPR137 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variants 2, 8-10, and 12, encodes isoform 2.
    Source sequence(s)
    AP001453
    Conserved Domains (1) summary
    cd21474
    Location:16325
    7tm_GPR137A; Integral membrane protein GPR137A, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily
  10. NM_001378082.1NP_001365011.1  integral membrane protein GPR137 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variants 2 and 8-11, encodes isoform 2.
    Source sequence(s)
    AP001453
    Conserved Domains (1) summary
    cd21474
    Location:16325
    7tm_GPR137A; Integral membrane protein GPR137A, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily
  11. NM_001378083.1NP_001365012.1  integral membrane protein GPR137 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13), as well as variant 3, encodes isoform 3.
    Source sequence(s)
    AP001453
    Conserved Domains (1) summary
    cd21474
    Location:16325
    7tm_GPR137A; Integral membrane protein GPR137A, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily
  12. NM_001378084.1NP_001365013.1  integral membrane protein GPR137 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14), as well as variants 5, 15, and 16, encodes isoform 5.
    Source sequence(s)
    AP001453
    Conserved Domains (2) summary
    cd21464
    Location:2749
    7tm_GPR137; TM helix 1 [structural motif]
    cl28897
    Location:16304
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  13. NM_001378085.1NP_001365014.1  integral membrane protein GPR137 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15), as well as variants 5, 14, and 16, encodes isoform 5.
    Source sequence(s)
    AP001453
    Conserved Domains (2) summary
    cd21464
    Location:2749
    7tm_GPR137; TM helix 1 [structural motif]
    cl28897
    Location:16304
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  14. NM_001378086.1NP_001365015.1  integral membrane protein GPR137 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16), as well as variants 5, 14, and 15, encodes isoform 5.
    Source sequence(s)
    AP001453
    Conserved Domains (2) summary
    cd21464
    Location:2749
    7tm_GPR137; TM helix 1 [structural motif]
    cl28897
    Location:16304
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  15. NM_001378087.1NP_001365016.1  integral membrane protein GPR137 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17), as well as variant 18, encodes isoform 6.
    Source sequence(s)
    AP001453
  16. NM_001378088.1NP_001365017.1  integral membrane protein GPR137 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18), as well as variant 17, encodes isoform 6.
    Source sequence(s)
    AP001453
  17. NM_001378089.1NP_001365018.1  integral membrane protein GPR137 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AP001453
    Conserved Domains (2) summary
    cd21464
    Location:2749
    7tm_GPR137; TM helix 1 [structural motif]
    cl28897
    Location:16273
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  18. NM_020155.4NP_064540.3  integral membrane protein GPR137 isoform 3

    See identical proteins and their annotated locations for NP_064540.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' and 3' UTRs and has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform 3) has a distinct C-terminus and is longer than isoform 1. Variants 3 and 13 both encode the same isoform (3).
    Source sequence(s)
    AJ250392, AK056094, AP001453, BU730610, BX119209
    Consensus CDS
    CCDS8066.1
    UniProtKB/Swiss-Prot
    Q96N19
    UniProtKB/TrEMBL
    Q9NQC5
    Related
    ENSP00000321698.3, ENST00000313074.7
    Conserved Domains (1) summary
    cd21474
    Location:16325
    7tm_GPR137A; Integral membrane protein GPR137A, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily

RNA

  1. NR_165394.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP001453
  2. NR_165395.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP001453
  3. NR_165396.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP001453
  4. NR_165397.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP001453

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    64270337..64289500
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545168.2XP_011543470.1  integral membrane protein GPR137 isoform X1

    See identical proteins and their annotated locations for XP_011543470.1

  2. XM_017018016.1XP_016873505.1  integral membrane protein GPR137 isoform X5

  3. XM_024448611.1XP_024304379.1  integral membrane protein GPR137 isoform X6

  4. XM_005274102.2XP_005274159.1  integral membrane protein GPR137 isoform X2

    See identical proteins and their annotated locations for XP_005274159.1

    UniProtKB/Swiss-Prot
    Q96N19
    Conserved Domains (1) summary
    cd21474
    Location:16325
    7tm_GPR137A; Integral membrane protein GPR137A, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily
  5. XM_005274104.2XP_005274161.1  integral membrane protein GPR137 isoform X2

    See identical proteins and their annotated locations for XP_005274161.1

    UniProtKB/Swiss-Prot
    Q96N19
    Conserved Domains (1) summary
    cd21474
    Location:16325
    7tm_GPR137A; Integral membrane protein GPR137A, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily
  6. XM_011545169.1XP_011543471.1  integral membrane protein GPR137 isoform X2

    See identical proteins and their annotated locations for XP_011543471.1

    UniProtKB/Swiss-Prot
    Q96N19
    Related
    ENSP00000411827.1, ENST00000411458.5
    Conserved Domains (1) summary
    cd21474
    Location:16325
    7tm_GPR137A; Integral membrane protein GPR137A, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily
  7. XM_005274100.2XP_005274157.1  integral membrane protein GPR137 isoform X2

    See identical proteins and their annotated locations for XP_005274157.1

    UniProtKB/Swiss-Prot
    Q96N19
    Conserved Domains (1) summary
    cd21474
    Location:16325
    7tm_GPR137A; Integral membrane protein GPR137A, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily

RNA

  1. XR_002957154.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001170726.1: Suppressed sequence

    Description
    NM_001170726.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
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