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SLAMF8 SLAM family member 8 [ Homo sapiens (human) ]

Gene ID: 56833, updated on 13-Mar-2020

Summary

Official Symbol
SLAMF8provided by HGNC
Official Full Name
SLAM family member 8provided by HGNC
Primary source
HGNC:HGNC:21391
See related
Ensembl:ENSG00000158714 MIM:606620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BLAME; CD353; SBBI42
Summary
This gene encodes a member of the CD2 family of cell surface proteins involved in lymphocyte activation. These proteins are characterized by Ig domains. This protein is expressed in lymphoid tissues, and studies of a similar protein in mouse suggest that it may function during B cell lineage commitment. The gene is found in a region of chromosome 1 containing many CD2 genes. [provided by RefSeq, Jul 2008]
Expression
Broad expression in appendix (RPKM 13.5), lymph node (RPKM 12.8) and 22 other tissues See more
Orthologs

Genomic context

See SLAMF8 in Genome Data Viewer
Location:
1q23.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (159826689..159837497)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (159796440..159807282)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371464 Neighboring gene Fc receptor like 6 Neighboring gene uncharacterized LOC107985217 Neighboring gene small nucleolar RNA host gene 28 Neighboring gene uncharacterized LOC107985216 Neighboring gene V-set and immunoglobulin domain containing 8 Neighboring gene cilia and flagella associated protein 45 Neighboring gene microRNA 4259

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20442, MGC129578

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
signaling receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
B-1 B cell lineage commitment ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cellular response to drug ISS
Inferred from Sequence or Structural Similarity
more info
 
defense response to bacterium ISS
Inferred from Sequence or Structural Similarity
more info
 
leukocyte chemotaxis involved in inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of dendritic cell chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of macrophage chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of monocyte chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of neutrophil migration ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of respiratory burst involved in inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
phagosome acidification ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of NAD(P)H oxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
cell surface NAS
Non-traceable Author Statement
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
SLAM family member 8
Names
B lymphocyte activator macrophage expressed
BCM-like membrane protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330741.2NP_001317670.1  SLAM family member 8 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL590560
    Consensus CDS
    CCDS81387.1
    UniProtKB/Swiss-Prot
    Q9P0V8
    Related
    ENSP00000357084.4, ENST00000368104.4
  2. NM_020125.3NP_064510.1  SLAM family member 8 isoform 1 precursor

    See identical proteins and their annotated locations for NP_064510.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF146761
    Consensus CDS
    CCDS1188.1
    UniProtKB/Swiss-Prot
    Q9P0V8
    Related
    ENSP00000289707.5, ENST00000289707.10

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    159826689..159837497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509775.2XP_011508077.1  SLAM family member 8 isoform X1

  2. XM_005245345.3XP_005245402.1  SLAM family member 8 isoform X3

  3. XM_011509777.3XP_011508079.1  SLAM family member 8 isoform X4

  4. XM_017001844.2XP_016857333.1  SLAM family member 8 isoform X4

  5. XM_017001845.2XP_016857334.1  SLAM family member 8 isoform X6

  6. XM_011509779.2XP_011508081.1  SLAM family member 8 isoform X8

  7. XM_011509776.2XP_011508078.1  SLAM family member 8 isoform X2

  8. XM_011509778.2XP_011508080.1  SLAM family member 8 isoform X5

  9. XM_017001846.1XP_016857335.1  SLAM family member 8 isoform X7

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