nfatc1 nuclear factor of activated T cells 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nfatc1provided by ZNC
Official Full Name: nuclear factor of activated T cells 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-060503-677
See related: Ensembl:ENSDARG00000036168 AllianceGenome:ZFIN:ZDB-GENE-060503-677
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:ch211-198c22.2
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within with a negative effect on lymphangiogenesis. Acts upstream of or within atrioventricular valve morphogenesis and response to mechanical stimulus. Predicted to be located in cytoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including adaxial cell; bone tissue; heart; olfactory system; and scale. Human ortholog(s) of this gene implicated in congenital heart disease and ventricular septal defect. Orthologous to human NFATC1 (nuclear factor of activated T cells 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	19	NC_133194.1 (24622075..24710990)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (22216778..22303614)

Chromosome 19 - NC_133194.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nfatc1 Promotes Interstitial Cell Formation During Cardiac Valve Development in Zebrafish.
Title: Nfatc1 Promotes Interstitial Cell Formation During Cardiac Valve Development in Zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within atrioventricular valve morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within atrioventricular valve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcineurin-NFAT signaling cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in epithelium development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within_negative_effect lymphangiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to mechanical stimulus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: nuclear factor of activated T-cells, cytoplasmic 1

Names: nuclear factor of activated T-cells calcineurin-dependent 1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045159.1 → NP_001038624.1 nuclear factor of activated T-cells, cytoplasmic 1

See identical proteins and their annotated locations for NP_001038624.1

Status: PROVISIONAL

Source sequence(s)

DQ530435

UniProtKB/TrEMBL

Q19AW4

Related

ENSDARP00000052520.5, ENSDART00000052521.6

Conserved Domains (2) summary

cd07881
Location:357 → 531

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

cl15674
Location:536 → 636

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...