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Prkn parkin RBR E3 ubiquitin protein ligase [ Rattus norvegicus (Norway rat) ]

Gene ID: 56816, updated on 8-Feb-2025

Summary

Official Symbol
Prknprovided by RGD
Official Full Name
parkin RBR E3 ubiquitin protein ligaseprovided by RGD
Primary source
RGD:61797
See related
EnsemblRapid:ENSRNOG00000055547 AllianceGenome:RGD:61797
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Park; Park2
Summary
Enables protein kinase binding activity. Involved in several processes, including cellular response to amino acid stimulus; modulation of chemical synaptic transmission; and regulation of apoptotic process. Located in several cellular components, including Golgi membrane; neuronal cell body; and synaptic vesicle. Is active in glutamatergic synapse; postsynapse; and synaptic vesicle membrane. Used to study Parkinson's disease. Biomarker of metabolic dysfunction-associated steatohepatitis and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 2; lung cancer; and ovarian cancer. Orthologous to human PRKN (parkin RBR E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Feb 2025]
Expression
Biased expression in Heart (RPKM 59.2), Muscle (RPKM 59.2) and 9 other tissues See more
Orthologs
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Genomic context

See Prkn in Genome Data Viewer
Location:
1q11
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (51236410..52430242, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (48688651..49882520, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (48880015..50069998, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108349099 Neighboring gene uncharacterized LOC134482716 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 4 Neighboring gene uncharacterized LOC134482715 Neighboring gene uncharacterized LOC120100099 Neighboring gene uncharacterized LOC134482719 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene uncharacterized LOC134482720 Neighboring gene parkin coregulated Neighboring gene uncharacterized LOC120100098 Neighboring gene colon adenocarcinoma hypermethylated

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables F-box domain binding IEA
Inferred from Electronic Annotation
more info
 
enables F-box domain binding ISO
Inferred from Sequence Orthology
more info
 
enables F-box domain binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables G protein-coupled receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables Hsp70 protein binding IEA
Inferred from Electronic Annotation
more info
 
enables Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables PDZ domain binding IEA
Inferred from Electronic Annotation
more info
 
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables PDZ domain binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-catenin binding IEA
Inferred from Electronic Annotation
more info
 
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables cullin family protein binding IEA
Inferred from Electronic Annotation
more info
 
enables cullin family protein binding ISO
Inferred from Sequence Orthology
more info
 
enables cullin family protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase binding IEA
Inferred from Electronic Annotation
more info
 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase binding IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
enables tubulin binding IEA
Inferred from Electronic Annotation
more info
 
enables tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin conjugating enzyme binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin conjugating enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin conjugating enzyme binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables ubiquitin-specific protease binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin-specific protease binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in adult locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within adult locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in adult locomotory behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in aggresome assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in aggresome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in aggresome assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in autophagy of mitochondrion ISO
Inferred from Sequence Orthology
more info
 
involved_in autophagy of mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to L-glutamate IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to L-glutamine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to hydrogen sulfide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to manganese ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to toxic substance IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to toxic substance ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to toxic substance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in dopamine metabolic process IEA
Inferred from Electronic Annotation
more info
 
NOT acts_upstream_of_or_within dopamine metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within dopamine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in dopamine uptake involved in synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within dopamine uptake involved in synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in free ubiquitin chain polymerization IEA
Inferred from Electronic Annotation
more info
 
involved_in free ubiquitin chain polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in learning IEA
Inferred from Electronic Annotation
more info
 
NOT acts_upstream_of_or_within learning ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within learning ISO
Inferred from Sequence Orthology
more info
 
NOT acts_upstream_of_or_within locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial fission ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mitochondrial fragmentation involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrion localization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitochondrion organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mitochondrion to lysosome vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrion to lysosome vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
 
involved_in mitophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitophagy IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within mitophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in mitophagy ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation by host of viral genome replication IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation by host of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of actin filament bundle assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of exosomal secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of exosomal secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of glucokinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glucokinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of insulin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of intralumenal vesicle formation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of intralumenal vesicle formation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mitochondrial fission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of mitochondrial fusion ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of primary amine oxidase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of reactive oxygen species biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of reactive oxygen species metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of release of cytochrome c from mitochondria IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of release of cytochrome c from mitochondria ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of spontaneous neurotransmitter secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of spontaneous neurotransmitter secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron cellular homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in norepinephrine metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within norepinephrine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ATP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of canonical NF-kappaB signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of dendrite extension IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of dendrite extension ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of mitochondrial fission ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of mitochondrial fusion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of mitochondrial fusion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitochondrial fusion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of mitochondrial membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mitophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mitophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neurotransmitter uptake IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neurotransmitter uptake ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein linear polyubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein linear polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein localization to membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tumor necrosis factor-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of type 2 mitophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of type 2 mitophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein K11-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K11-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein K48-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K6-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in protein K6-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K6-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein K63-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K63-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein autoubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein destabilization IEA
Inferred from Electronic Annotation
more info
 
involved_in protein destabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein destabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization to mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to mitochondrion IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization to mitochondrion ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein monoubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein monoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein polyubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein stabilization IEA
Inferred from Electronic Annotation
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of autophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cellular response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cellular response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cellular response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of dopamine metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of dopamine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitochondrial membrane potential IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of mitochondrial membrane potential ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitochondrion organization ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within regulation of neurotransmitter secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synaptic vesicle endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation protein catabolic process at presynapse IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation protein catabolic process at presynapse ISO
Inferred from Sequence Orthology
more info
 
involved_in response to corticosterone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to curcumin IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
 
involved_in response to endoplasmic reticulum stress IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
involved_in response to muscle activity IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to unfolded protein IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in startle response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within startle response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within synaptic transmission, dopaminergic ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic transmission, glutamatergic IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
involved_in type 2 mitophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in type 2 mitophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of Parkin-FBXW7-Cul1 ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
 
part_of Parkin-FBXW7-Cul1 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
part_of Parkin-FBXW7-Cul1 ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
located_in aggresome IEA
Inferred from Electronic Annotation
more info
 
located_in aggresome ISO
Inferred from Sequence Orthology
more info
 
located_in aggresome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in dopaminergic synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in dopaminergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in intracellular vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitochondrion-derived vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion-derived vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in terminal bouton IDA
Inferred from Direct Assay
more info
PubMed 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
 
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
part_of ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase parkin
Names
Parkinson disease (autosomal recessive, juvenile) 2, parkin
parkin RBR E3 ubiquitin protein ligase 2
parkin variant SV5DEL
parkinson protein 2, E3 ubiquitin protein ligase
NP_064478.1
XP_038944638.1
XP_038944641.1
XP_038944642.1
XP_038944645.1
XP_038944652.1
XP_063128104.1
XP_063128107.1
XP_063128110.1
XP_063128114.1
XP_063128116.1
XP_063128124.1
XP_063128127.1
XP_063128128.1
XP_063128130.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020093.1NP_064478.1  E3 ubiquitin-protein ligase parkin

    See identical proteins and their annotated locations for NP_064478.1

    Status: PROVISIONAL

    Source sequence(s)
    AB039878
    UniProtKB/TrEMBL
    A0A1S7IWU1
    Related
    ENSRNOP00000077507.2, ENSRNOT00000096213.2
    Conserved Domains (4) summary
    cd01798
    Location:372
    parkin_N; amino-terminal ubiquitin-like of parkin protein
    smart00213
    Location:172
    UBQ; Ubiquitin homologues
    smart00647
    Location:313375
    IBR; In Between Ring fingers
    pfam01485
    Location:413453
    IBR; IBR domain, a half RING-finger domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    51236410..52430242 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272040.1XP_063128110.1  E3 ubiquitin-protein ligase parkin isoform X4

    UniProtKB/TrEMBL
    A0A8I6A5N7, D3JVU6
  2. XM_063272046.1XP_063128116.1  E3 ubiquitin-protein ligase parkin isoform X8

    UniProtKB/Swiss-Prot
    Q8K5C3, Q8K5C4, Q8K5C5, Q8K5C6, Q8VHY6, Q9JK66, Q9JLL1, Q9JM64
    UniProtKB/TrEMBL
    A0A1S7IWU1, A6KJZ1
    Related
    ENSRNOP00000075137.3, ENSRNOT00000086127.3
  3. XM_039088710.2XP_038944638.1  E3 ubiquitin-protein ligase parkin isoform X3

    UniProtKB/TrEMBL
    A0A8I6A5N7
    Related
    ENSRNOP00000070559.3, ENSRNOT00000089439.3
    Conserved Domains (4) summary
    cd01798
    Location:376
    Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins
    pfam01485
    Location:343405
    IBR; IBR domain, a half RING-finger domain
    pfam17978
    Location:258348
    zf-RING_14; RING/Ubox like zinc-binding domain
    cd21382
    Location:146259
    RING0_parkin; RING finger-like zinc-binding domain 0 of parkin
  4. XM_039088724.2XP_038944652.1  E3 ubiquitin-protein ligase parkin isoform X10

    UniProtKB/TrEMBL
    S4X294
    Related
    ENSRNOP00000071167.2, ENSRNOT00000090521.3
    Conserved Domains (3) summary
    pfam01485
    Location:148210
    IBR; IBR domain, a half RING-finger domain
    pfam17978
    Location:63153
    zf-RING_14; RING/Ubox like zinc-binding domain
    cd21382
    Location:664
    RING0_parkin; RING finger-like zinc-binding domain 0 of parkin
  5. XM_063272054.1XP_063128124.1  E3 ubiquitin-protein ligase parkin isoform X10

    UniProtKB/TrEMBL
    S4X294
  6. XM_039088713.2XP_038944641.1  E3 ubiquitin-protein ligase parkin isoform X5

    UniProtKB/TrEMBL
    A0A8I6A5N7
    Conserved Domains (4) summary
    cd01798
    Location:274
    Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins
    pfam01485
    Location:341403
    IBR; IBR domain, a half RING-finger domain
    pfam17978
    Location:256346
    zf-RING_14; RING/Ubox like zinc-binding domain
    cd21382
    Location:144257
    RING0_parkin; RING finger-like zinc-binding domain 0 of parkin
  7. XM_063272037.1XP_063128107.1  E3 ubiquitin-protein ligase parkin isoform X2

    UniProtKB/TrEMBL
    A0A8I6A5N7
  8. XM_063272034.1XP_063128104.1  E3 ubiquitin-protein ligase parkin isoform X1

    UniProtKB/TrEMBL
    A0A8I6A5N7
  9. XM_063272044.1XP_063128114.1  E3 ubiquitin-protein ligase parkin isoform X7

    UniProtKB/Swiss-Prot
    Q8K5C3, Q8K5C4, Q8K5C5, Q8K5C6, Q8VHY6, Q9JK66, Q9JLL1, Q9JM64
    UniProtKB/TrEMBL
    A0A1S7IWU1, A6KJZ1
  10. XM_039088717.2XP_038944645.1  E3 ubiquitin-protein ligase parkin isoform X9

    UniProtKB/TrEMBL
    A0A8I6GIU4
    Conserved Domains (4) summary
    cd01798
    Location:30103
    Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins
    pfam01485
    Location:312374
    IBR; IBR domain, a half RING-finger domain
    pfam17978
    Location:227317
    zf-RING_14; RING/Ubox like zinc-binding domain
    cd21382
    Location:173228
    RING0_parkin; RING finger-like zinc-binding domain 0 of parkin
  11. XM_039088714.2XP_038944642.1  E3 ubiquitin-protein ligase parkin isoform X6

    UniProtKB/Swiss-Prot
    Q8K5C3, Q8K5C4, Q8K5C5, Q8K5C6, Q8VHY6, Q9JK66, Q9JLL1, Q9JM64
    UniProtKB/TrEMBL
    A6KJZ1
    Related
    ENSRNOP00000091214.2, ENSRNOT00000105555.2
    Conserved Domains (4) summary
    cd01798
    Location:30103
    Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins
    pfam01485
    Location:340402
    IBR; IBR domain, a half RING-finger domain
    pfam17978
    Location:255345
    zf-RING_14; RING/Ubox like zinc-binding domain
    cd21382
    Location:173256
    RING0_parkin; RING finger-like zinc-binding domain 0 of parkin
  12. XM_063272057.1XP_063128127.1  E3 ubiquitin-protein ligase parkin isoform X11

    UniProtKB/TrEMBL
    A6KJZ3, S4X294
    Related
    ENSRNOP00000072264.3, ENSRNOT00000083884.3
  13. XM_063272060.1XP_063128130.1  E3 ubiquitin-protein ligase parkin isoform X13

    UniProtKB/TrEMBL
    A0A0G2JY87
  14. XM_063272058.1XP_063128128.1  E3 ubiquitin-protein ligase parkin isoform X12