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Pth1r parathyroid hormone 1 receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 56813, updated on 10-Oct-2024

Summary

Official Symbol
Pth1rprovided by RGD
Official Full Name
parathyroid hormone 1 receptorprovided by RGD
Primary source
RGD:3442
See related
EnsemblRapid:ENSRNOG00000020948 AllianceGenome:RGD:3442
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pthr; Pthr1; PTHrel
Summary
Enables parathyroid hormone receptor activity and peptide hormone binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; and positive regulation of inositol phosphate biosynthetic process. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and brush border membrane. Part of receptor complex. Used to study hypercalcemia. Human ortholog(s) of this gene implicated in Eiken syndrome; Jansen's metaphyseal chondrodysplasia; chondrodysplasia Blomstrand type; osteochondrodysplasia; and primary failure of tooth eruption. Orthologous to human PTH1R (parathyroid hormone 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 243.9), Liver (RPKM 24.2) and 1 other tissue See more
Orthologs
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Genomic context

See Pth1r in Genome Data Viewer
Location:
8q32
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (119572295..119597405, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (110693910..110725458, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (118984531..119012803, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene neurobeachin-like 2 Neighboring gene coiled-coil domain containing 12 Neighboring gene myosin light chain 3 Neighboring gene serine protease 42

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables parathyroid hormone receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables parathyroid hormone receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables parathyroid hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables parathyroid hormone receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peptide hormone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables peptide hormone binding IEA
Inferred from Electronic Annotation
more info
 
enables peptide hormone binding ISO
Inferred from Sequence Orthology
more info
 
enables peptide hormone binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in bone mineralization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within bone mineralization ISO
Inferred from Sequence Orthology
more info
 
involved_in bone resorption IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within bone resorption ISO
Inferred from Sequence Orthology
more info
 
involved_in cell maturation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in chondrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chondrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within intracellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ossification ISO
Inferred from Sequence Orthology
more info
 
involved_in osteoblast development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within osteoblast development ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IC
Inferred by Curator
more info
PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of inositol phosphate biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within skeletal system development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in brush border membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
parathyroid hormone/parathyroid hormone-related peptide receptor
Names
PTH/PTHr receptor
PTH/PTHrP type I receptor
PTH1 receptor
parathyroid hormone receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020073.2NP_064458.1  parathyroid hormone/parathyroid hormone-related peptide receptor precursor

    See identical proteins and their annotated locations for NP_064458.1

    Status: PROVISIONAL

    Source sequence(s)
    L19475
    UniProtKB/Swiss-Prot
    P25961
    UniProtKB/TrEMBL
    A6I3G4, A6I3G5
    Related
    ENSRNOP00000080822.1, ENSRNOT00000108530.2
    Conserved Domains (3) summary
    pfam02793
    Location:105170
    HRM; Hormone receptor domain
    cd14964
    Location:186211
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:184476
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    119572295..119597405 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039082024.2XP_038937952.2  parathyroid hormone/parathyroid hormone-related peptide receptor isoform X1

    Related
    ENSRNOP00000094940.1, ENSRNOT00000100984.2
  2. XM_006243999.4XP_006244061.1  parathyroid hormone/parathyroid hormone-related peptide receptor isoform X2

    See identical proteins and their annotated locations for XP_006244061.1

    UniProtKB/Swiss-Prot
    P25961
    UniProtKB/TrEMBL
    A6I3G4, A6I3G5
    Related
    ENSRNOP00000028435.3, ENSRNOT00000028435.6
    Conserved Domains (3) summary
    pfam02793
    Location:105170
    HRM; Hormone receptor domain
    cd14964
    Location:186211
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:184476
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  3. XM_006244002.4XP_006244064.1  parathyroid hormone/parathyroid hormone-related peptide receptor isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZQF2
    Related
    ENSRNOP00000111934.1, ENSRNOT00000135570.1
    Conserved Domains (2) summary
    pfam00002
    Location:163434
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:84149
    HRM; Hormone receptor domain