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Adam2 ADAM metallopeptidase domain 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 56806, updated on 5-Jun-2021

Summary

Official Symbol
Adam2provided by RGD
Official Full Name
ADAM metallopeptidase domain 2provided by RGD
Primary source
RGD:69299
See related
Ensembl:ENSRNOG00000017027
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ftnb; PH-30
Summary
may play a role in sperm-oocyte binding and fusion [RGD, Feb 2006]
Expression
Restricted expression toward (RPKM 339.4) See more
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Genomic context

See Adam2 in Genome Data Viewer
Location:
15p12
Exon count:
22
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (40242783..40284025, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (42708536..42751281, complement)

Chromosome 15 - NC_051350.1Genomic Context describing neighboring genes Neighboring gene serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like Neighboring gene clusterin Neighboring gene gulonolactone (L-) oxidase Neighboring gene uncharacterized LOC102555773 Neighboring gene epoxide hydrolase 2 Neighboring gene cholinergic receptor nicotinic alpha 2 subunit

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in adult behavior IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within adult behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in binding of sperm to zona pellucida IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in male gonad development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in single fertilization IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in visual learning IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within visual learning ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
disintegrin and metalloproteinase domain-containing protein 2
Names
A disintegrin and metalloprotease domain 2 (Fertilin beta)
ADAM 2
PH30
PH30-beta
a disintegrin and metallopeptidase domain 2
a disintegrin and metalloprotease domain (ADAM) 2
fertilin beta
fertilin subunit beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020077.2NP_064462.2  disintegrin and metalloproteinase domain-containing protein 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000270
    Related
    ENSRNOP00000061122.3, ENSRNOT00000066478.3
    Conserved Domains (4) summary
    smart00050
    Location:398475
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:477613
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:184381
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:32147
    Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051350.1 Reference mRatBN7.2 Primary Assembly

    Range
    40242783..40284025 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093614.1XP_038949542.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X1

    Conserved Domains (4) summary
    smart00050
    Location:346423
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:425561
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:132329
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:32107
    Pep_M12B_propep; Reprolysin family propeptide
  2. XM_039093615.1XP_038949543.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X2

    Conserved Domains (3) summary
    smart00050
    Location:235312
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:314450
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:21218
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
  3. XM_039093616.1XP_038949544.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X3

    Conserved Domains (3) summary
    smart00050
    Location:161238
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:240376
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:1144
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
  4. XM_039093617.1XP_038949545.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X4

    Conserved Domains (3) summary
    smart00050
    Location:74151
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:153289
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:157
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
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