crhr1 corticotropin releasing hormone receptor 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: crhr1provided by ZNC
Official Full Name: corticotropin releasing hormone receptor 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-081231-1
See related: Ensembl:ENSDARG00000003989 AllianceGenome:ZFIN:ZDB-GENE-081231-1
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: crfr1
Summary: Predicted to enable G protein-coupled receptor activity; corticotropin-releasing hormone binding activity; and corticotropin-releasing hormone receptor activity. Acts upstream of or within response to cortisol and response to stress. Predicted to be located in membrane. Predicted to be active in neuron projection and plasma membrane. Is expressed in several structures, including brain; gill; gonad; heart; and liver. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and obesity. Orthologous to human CRHR1 (corticotropin releasing hormone receptor 1). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	3	NC_133178.1 (20404713..20630572)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (21669620..21894784)

Chromosome 3 - NC_133178.1 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables corticotrophin-releasing factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables corticotropin-releasing hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables corticotropin-releasing hormone receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hormone stimulus	IEA Inferred from Electronic Annotation more info
involved_in regulation of transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to cortisol	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within swimming behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within thigmotaxis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

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The following sections contain reference sequences that belong to a specific genome build. Explain