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col6a2 collagen, type VI, alpha 2 [ Danio rerio (zebrafish) ]

Gene ID: 567771, updated on 9-Sep-2025
Official Symbol
col6a2provided by ZNC
Official Full Name
collagen, type VI, alpha 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-070501-7
See related
Ensembl:ENSDARG00000061436 AllianceGenome:ZFIN:ZDB-GENE-070501-7
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Acts upstream of or within axonogenesis; muscle cell development; and muscle organ development. Predicted to be located in extracellular region. Predicted to be part of collagen trimer. Predicted to be active in collagen-containing extracellular matrix. Is expressed in several structures, including cardiovascular system; digestive system; head; integument; and musculature system. Human ortholog(s) of this gene implicated in Bethlem myopathy and Ullrich congenital muscular dystrophy 1B. Orthologous to human COL6A2 (collagen type VI alpha 2 chain). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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See col6a2 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 11 NC_133186.1 (36210489..36249695, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 11 NC_007122.7 (33921355..33960449, complement)

Chromosome 11 - NC_133186.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC141376644 Neighboring gene phosphorylase kinase, alpha 2 (liver) Neighboring gene uncharacterized LOC141376649 Neighboring gene uncharacterized LOC141376701 Neighboring gene uncharacterized LOC141376646 Neighboring gene collagen, type VI, alpha 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Two novel COLVI long chains in zebrafish that are essential for muscle development. Ramanoudjame L, et al. Hum Mol Genet, 2015 Dec 1. PMID 26362255
  2. Collagen VI ablation in zebrafish causes neuromuscular defects during developmental and adult stages. Tonelotto V, et al. Matrix Biol, 2022 Sep. PMID 35961424
  3. Spatio-temporal expression and distribution of collagen VI during zebrafish development. Tonelotto V, et al. Sci Rep, 2019 Dec 27. PMID 31882701, Free PMC Article
  4. CBP and P300 regulate distinct gene networks required for human primary myoblast differentiation and muscle integrity. Fauquier L, et al. Sci Rep, 2018 Aug 22. PMID 30135524, Free PMC Article
  5. Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish. Wehner D, et al. Nat Commun, 2017 Jul 25. PMID 28743881, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within axonogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within muscle cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within muscle organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
collagen alpha-2(VI) chain

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RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133186.1 Reference GRCz12tu Primary Assembly

    Range
    36210489..36249695 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009306168.5 → XP_009304443.2  collagen alpha-2(VI) chain isoform X2

    UniProtKB/TrEMBL
    A0A8M3AXV0

  2. XM_021479872.3 → XP_021335547.1  collagen alpha-2(VI) chain isoform X1

    UniProtKB/TrEMBL
    A0A8M9PVL2
    Conserved Domains (3) summary
    pfam01391
    Location:346 → 404
    Collagen; Collagen triple helix repeat (20 copies)
    pfam00092
    Location:903 → 1078
    VWA; von Willebrand factor type A domain
    cl00057
    Location:681 → 872
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  3. XM_691072.10 → XP_696164.2  collagen alpha-2(VI) chain isoform X4

    See identical proteins and their annotated locations for XP_696164.2

    UniProtKB/TrEMBL
    A0A8N7TFA2, E7FCV8, F1Q518
    Related
    ENSDARP00000082031.4
    Conserved Domains (3) summary
    pfam01391
    Location:271 → 329
    Collagen; Collagen triple helix repeat (20 copies)
    pfam00092
    Location:828 → 1003
    VWA; von Willebrand factor type A domain
    cl00057
    Location:606 → 797
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  4. XM_021479873.3 → XP_021335548.1  collagen alpha-2(VI) chain isoform X3

    UniProtKB/TrEMBL
    A0A8M9Q7S8
    Conserved Domains (3) summary
    pfam01391
    Location:277 → 335
    Collagen; Collagen triple helix repeat (20 copies)
    pfam00092
    Location:834 → 1009
    VWA; von Willebrand factor type A domain
    cl00057
    Location:612 → 803
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
Nucleotide Protein Strain
Heading Accession and Version

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