Format

Send to:

Choose Destination

Srek1 splicing regulatory glutamic acid and lysine rich protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 56763, updated on 2-Oct-2018

Summary

Official Symbol
Srek1provided by RGD
Official Full Name
splicing regulatory glutamic acid and lysine rich protein 1provided by RGD
Primary source
RGD:621696
See related
Ensembl:ENSRNOG00000032735
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sfrs12; Srrp86; Srsf12
Summary
comprises of a single amino-terminal RNA recognition motif and two carboxy-terminal domains rich in serine-arginine (SR) dipeptides [RGD, Feb 2006]
Expression
Biased expression in Adrenal (RPKM 166.6), Thymus (RPKM 153.7) and 9 other tissues See more
Orthologs

Genomic context

See Srek1 in Genome Data Viewer
Location:
2q12
Exon count:
13
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (33806035..33841594, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (52935275..52970575, complement)

Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene microtubule associated serine/threonine kinase family member 4 Neighboring gene uncharacterized LOC108350209 Neighboring gene uncharacterized LOC103695096 Neighboring gene AKT-interacting protein-like Neighboring gene erbb2 interacting protein

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

  • mRNA processing, organism-specific biosystem (from WikiPathways)
    mRNA processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' pol...

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
RNA binding IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA splicing IEA
Inferred from Electronic Annotation
more info
 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
regulation of alternative mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear speck ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
splicing regulatory glutamine/lysine-rich protein 1
Names
SR-related protein of 86 kDa
serine/arginine-rich splicing factor 12
serine/arginine-rich-splicing regulatory protein 86
splicing factor, arginine/serine-rich 12
splicing regulatory glutamic acid/lysine-rich protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020092.1NP_064477.1  splicing regulatory glutamine/lysine-rich protein 1

    See identical proteins and their annotated locations for NP_064477.1

    Status: PROVISIONAL

    Source sequence(s)
    AF234765
    UniProtKB/Swiss-Prot
    Q9JKL7
    Conserved Domains (1) summary
    cd12260
    Location:65150
    RRM2_SREK1; RNA recognition motif 2 in splicing regulatory glutamine/lysine-rich protein 1 (SREK1) and similar proteins

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

    Range
    33806035..33841594 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231892.3XP_006231954.1  splicing regulatory glutamine/lysine-rich protein 1 isoform X1

    UniProtKB/TrEMBL
    G3V9I9
    Related
    ENSRNOP00000049050.3, ENSRNOT00000040533.3
    Conserved Domains (3) summary
    COG0724
    Location:157262
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12260
    Location:181266
    RRM2_SREK1; RNA recognition motif 2 in splicing regulatory glutamine/lysine-rich protein 1 (SREK1) and similar proteins
    cd12519
    Location:2099
    RRM1_SREK1; RNA recognition motif 1 in splicing regulatory glutamine/lysine-rich protein 1 (SREK1) and similar proteins
  2. XM_006231894.3XP_006231956.1  splicing regulatory glutamine/lysine-rich protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006231956.1

    Conserved Domains (1) summary
    cd12260
    Location:65150
    RRM2_SREK1; RNA recognition motif 2 in splicing regulatory glutamine/lysine-rich protein 1 (SREK1) and similar proteins

Alternate Rn_Celera

Genomic

  1. AC_000070.1 Alternate Rn_Celera

    Range
    30833959..30852836 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center