shq1 SHQ1, H/ACA ribonucleoprotein assembly factor [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: shq1provided by ZNC
Official Full Name: SHQ1, H/ACA ribonucleoprotein assembly factorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070112-1412
See related: Ensembl:ENSDARG00000058522 AllianceGenome:ZFIN:ZDB-GENE-070112-1412
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:158255
Summary: Predicted to enable unfolded protein binding activity. Predicted to be involved in box H/ACA snoRNP assembly. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm and nucleoplasm. Human ortholog(s) of this gene implicated in dystonia 35, childhood-onset. Orthologous to human SHQ1 (SHQ1, H/ACA ribonucleoprotein assembly factor). [provided by Alliance of Genome Resources, Mar 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (44089189..44161290, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (44091653..44163754, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in box H/ACA snoRNP assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within box H/ACA snoRNP assembly	IEA Inferred from Electronic Annotation more info
involved_in protein-RNA complex assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein SHQ1 homolog

Names: SHQ1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080600.2 → NP_001074069.2 protein SHQ1 homolog

Status: VALIDATED

Source sequence(s)

BX546459, EH443650, EH469534, EH518762

UniProtKB/Swiss-Prot

A1L1R0

UniProtKB/TrEMBL

A0A8M1NBN6, F1QC67

Related

ENSDARP00000036580.5, ENSDART00000035513.7

Conserved Domains (2) summary

pfam04925
Location:233 → 405

SHQ1; SHQ1 protein

cl00175
Location:9 → 75

alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.