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Psrc1 proline/serine-rich coiled-coil 1 [ Mus musculus (house mouse) ]

Gene ID: 56742, updated on 26-Sep-2022

Summary

Official Symbol
Psrc1provided by MGI
Official Full Name
proline/serine-rich coiled-coil 1provided by MGI
Primary source
MGI:MGI:1913099
See related
Ensembl:ENSMUSG00000068744 AllianceGenome:MGI:1913099
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dda3; 5430413I02Rik
Summary
Enables microtubule binding activity. Involved in several processes, including microtubule bundle formation; positive regulation of microtubule polymerization; and positive regulation of nitrogen compound metabolic process. Located in cytoplasm; midbody; and spindle. Is expressed in several structures, including brain ventricular layer; lung; rest of cerebellum marginal layer; submandibular gland primordium; and thymus primordium. Orthologous to human PSRC1 (proline and serine rich coiled-coil 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 24.5), limb E14.5 (RPKM 18.2) and 14 other tissues See more
Orthologs
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Genomic context

See Psrc1 in Genome Data Viewer
Location:
3; 3 F3
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (108291120..108295547)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (108383804..108388231)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 19343 Neighboring gene sortilin 1 Neighboring gene myosin binding protein H-like Neighboring gene predicted gene 12522 Neighboring gene cadherin, EGF LAG seven-pass G-type receptor 2 Neighboring gene predicted gene, 52630 Neighboring gene seryl-aminoacyl-tRNA synthetase Neighboring gene predicted gene, 22942

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC7063

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in spindle IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with spindle microtubule ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with spindle pole ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
proline/serine-rich coiled-coil protein 1
Names
differential display and activated by p53
p53-regulated DDA3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190161.1NP_001177090.1  proline/serine-rich coiled-coil protein 1

    See identical proteins and their annotated locations for NP_001177090.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK041835, BY231608
    Consensus CDS
    CCDS17758.1
    UniProtKB/Swiss-Prot
    Q9D0P7, Q9QXY5
    Related
    ENSMUSP00000099689.2, ENSMUST00000102629.8
    Conserved Domains (1) summary
    pfam15259
    Location:10124
    GTSE1_N; G-2 and S-phase expressed 1
  2. NM_019976.3NP_064360.1  proline/serine-rich coiled-coil protein 1

    See identical proteins and their annotated locations for NP_064360.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF156598, AK041835, BY080522
    Consensus CDS
    CCDS17758.1
    UniProtKB/Swiss-Prot
    Q9D0P7, Q9QXY5
    Related
    ENSMUSP00000088049.4, ENSMUST00000090561.10
    Conserved Domains (1) summary
    pfam15259
    Location:10124
    GTSE1_N; G-2 and S-phase expressed 1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    108291120..108295547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)