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lepr leptin receptor [ Danio rerio (zebrafish) ]

Gene ID: 567241, updated on 9-Sep-2025
Official Symbol
leprprovided by ZNC
Official Full Name
leptin receptorprovided by ZNC
Primary source
ZFIN:ZDB-GENE-080104-1
See related
Ensembl:ENSDARG00000070961 AllianceGenome:ZFIN:ZDB-GENE-080104-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
obr
Summary
Predicted to enable cytokine binding activity and cytokine receptor activity. Involved in leptin-mediated signaling pathway and regulation of canonical Wnt signaling pathway. Acts upstream of or within several processes, including oocyte maturation; ovulation; and type B pancreatic cell development. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including digestive system; musculature system; nervous system; notochord; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); liver disease (multiple); obesity; obstructive sleep apnea; and type 2 diabetes mellitus. Orthologous to human LEPR (leptin receptor). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
human mouse all
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See lepr in Genome Data Viewer
Location:
chromosome: 6
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 6 NC_133181.1 (33699428..33778049, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 6 NC_007117.7 (31184205..31262646, complement)

Chromosome 6 - NC_133181.1Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 4B, cAMP-specific a Neighboring gene uncharacterized LOC141386299 Neighboring gene uncharacterized LOC141386301 Neighboring gene uncharacterized LOC137490216 Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 6

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Expression of leptin receptor gene in developing and adult zebrafish. Liu Q, et al. Gen Comp Endocrinol, 2010 Apr 1. PMID 19941865, Free PMC Article
  2. Leptin expression affects metabolic rate in zebrafish embryos (D. rerio). Dalman MR, et al. Front Physiol, 2013. PMID 23847542, Free PMC Article
  3. Expression and distribution of leptin and its receptors in the digestive tract of DIO (diet-induced obese) zebrafish. Mania M, et al. Ann Anat, 2017 Jul. PMID 28477448
  4. Leptin and leptin receptor: analysis of a structure to function relationship in interaction and evolution from humans to fish. Prokop JW, et al. Peptides, 2012 Dec. PMID 23085324, Free PMC Article
  5. Leptin system loss of function in the absence of obesity in zebrafish. Bagivalu Lakshminarasimha A, et al. J Endocrinol, 2021 Aug 16. PMID 34265742

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Impaired leptin signaling causes subfertility in female zebrafish.
    Title: Impaired leptin signaling causes subfertility in female zebrafish.
  2. Leptin receptor-deficient (knockout) zebrafish: Effects on nutrient acquisition.
    Title: Leptin receptor-deficient (knockout) zebrafish: Effects on nutrient acquisition.
  3. Leptin receptor-deficient larvae have increased numbers of beta-cells and insulin mRNA. beta-cell hyperplasia in response to high fat feeding or peripheral insulin resistance require the leptin receptor.
    Title: Leptin signaling regulates glucose homeostasis, but not adipostasis, in the zebrafish.
  4. results showed that leptin receptor expression was both spatially and temporally regulated in zebrafish
    Title: Expression of leptin receptor gene in developing and adult zebrafish.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within camera-type eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within inner ear development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in leptin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within oocyte maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ovulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to glucose IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within type B pancreatic cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
leptin receptor

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001309403.1 → NP_001296332.1  leptin receptor precursor

    See identical proteins and their annotated locations for NP_001296332.1

    Status: VALIDATED

    Source sequence(s)
    JBMGRA010000006
    UniProtKB/TrEMBL
    A0A8M1P6L4, F1QUB9
    Related
    ENSDARP00000073629.4, ENSDART00000079173.6
    Conserved Domains (2) summary
    cd00063
    Location:181 → 271
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:301 → 346
    Lep_receptor_Ig; Ig-like C2-type domain

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133181.1 Reference GRCz12tu Primary Assembly

    Range
    33699428..33778049 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021476908.2 → XP_021332583.1  leptin receptor isoform X2

    UniProtKB/TrEMBL
    A0A8M1P6L4, F1QUB9
    Conserved Domains (2) summary
    cd00063
    Location:181 → 271
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:301 → 346
    Lep_receptor_Ig; Ig-like C2-type domain

  2. XM_073953113.1 → XP_073809214.1  leptin receptor isoform X2

    UniProtKB/TrEMBL
    A0A8M1P6L4, F1QUB9

  3. XM_068221762.2 → XP_068077863.1  leptin receptor isoform X1

    UniProtKB/TrEMBL
    A0AB32TVW1

RNA

  1. XR_012407393.1 RNA Sequence

  2. XR_012407394.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001113376.1: Suppressed sequence

    Description
    NM_001113376.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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