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PSG4 pregnancy specific beta-1-glycoprotein 4 [ Homo sapiens (human) ]

Gene ID: 5672, updated on 11-Jun-2021

Summary

Official Symbol
PSG4provided by HGNC
Official Full Name
pregnancy specific beta-1-glycoprotein 4provided by HGNC
Primary source
HGNC:HGNC:9521
See related
Ensembl:ENSG00000243137 MIM:176393
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSG9; PSBG-4; PSBG-9
Summary
The protein encoded by this gene is a pregnancy-specific glycoprotein (PSG), one of several encoded by a cluster of similar genes on chromosome 19. This gene is a member of the carcinoembryonic antigen (CEA) gene family and may play a role in regulation of the innate immune system. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Expression
Restricted expression toward placenta (RPKM 137.5) See more
Orthologs
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Genomic context

See PSG4 in Genome Data Viewer
Location:
19q13.31
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (43192702..43205638, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (43696854..43709790, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985349 Neighboring gene pregnancy specific beta-1-glycoprotein 9 pseudogene Neighboring gene pregnancy specific beta-1-glycoprotein 5 Neighboring gene uncharacterized LOC284344 Neighboring gene CEA cell adhesion molecule pseudogene 10 Neighboring gene pregnancy specific beta-1-glycoprotein 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in female pregnancy TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
pregnancy-specific beta-1-glycoprotein 4
Names
PS-beta-G-4
PS-beta-G-9
Pregnancy-specific beta-1-glycoprotein-4
pregnancy-specific beta-1-glycoprotein 9
pregnancy-specific glycoprotein 4
pregnancy-specific glycoprotein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276495.2NP_001263424.1  pregnancy-specific beta-1-glycoprotein 4 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC005392, AK075149, BC008405
    Consensus CDS
    CCDS62695.1
    UniProtKB/TrEMBL
    B3KQL2, Q96QL5
    Related
    ENSP00000387864.2, ENST00000433626.6
    Conserved Domains (4) summary
    cd05774
    Location:36138
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:246318
    IG_like; Immunoglobulin like
    pfam13895
    Location:242320
    Ig_2; Immunoglobulin domain
    cl11960
    Location:148236
    Ig; Immunoglobulin domain
  2. NM_001316339.2NP_001303268.1  pregnancy-specific beta-1-glycoprotein 4 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC005392, BC008405, BC063127, DA837940, DA838139
    UniProtKB/TrEMBL
    Q6P520, Q96QL5
    Related
    ENSP00000471124.1, ENST00000596907.5
    Conserved Domains (3) summary
    smart00410
    Location:217289
    IG_like; Immunoglobulin like
    pfam13895
    Location:213291
    Ig_2; Immunoglobulin domain
    cl11960
    Location:119207
    Ig; Immunoglobulin domain
  3. NM_002780.5NP_002771.2  pregnancy-specific beta-1-glycoprotein 4 isoform 1 precursor

    See identical proteins and their annotated locations for NP_002771.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC005392, BC008405, BC013431
    Consensus CDS
    CCDS46093.1
    UniProtKB/Swiss-Prot
    Q00888
    UniProtKB/TrEMBL
    Q96QL5
    Related
    ENSP00000384770.3, ENST00000405312.8
    Conserved Domains (4) summary
    cd05774
    Location:36138
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:339411
    IG_like; Immunoglobulin like
    pfam13895
    Location:335413
    Ig_2; Immunoglobulin domain
    cl11960
    Location:241329
    Ig; Immunoglobulin domain
  4. NM_213633.3NP_998798.1  pregnancy-specific beta-1-glycoprotein 4 isoform 2 precursor

    See identical proteins and their annotated locations for NP_998798.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC005392, BC008405, U18469
    Consensus CDS
    CCDS33039.1
    UniProtKB/Swiss-Prot
    Q00888
    UniProtKB/TrEMBL
    Q96QL5
    Related
    ENSP00000244295.8, ENST00000244295.13
    Conserved Domains (4) summary
    cd05774
    Location:36138
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:246318
    IG_like; Immunoglobulin like
    pfam13895
    Location:242320
    Ig_2; Immunoglobulin domain
    cl11960
    Location:148236
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    43192702..43205638 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027001.2XP_016882490.1  pregnancy-specific beta-1-glycoprotein 4 isoform X2

  2. XM_017027002.2XP_016882491.1  pregnancy-specific beta-1-glycoprotein 4 isoform X3

  3. XM_017026997.2XP_016882486.1  pregnancy-specific beta-1-glycoprotein 4 isoform X1

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