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Mtor mechanistic target of rapamycin kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 56718, updated on 15-Jul-2018
Official Symbol
Mtorprovided by RGD
Official Full Name
mechanistic target of rapamycin kinaseprovided by RGD
Primary source
RGD:68371
See related
Ensembl:ENSRNOG00000009615
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Frap1; RAFT1
Summary
binds the complex formed by the immunosuppressive drug rapamycin and its receptor FKBP12; may play a role in the cell cycle G1 to S transition [RGD, Feb 2006]
Annotation information
Annotation category: partial on reference assembly
Expression
Biased expression in Kidney (RPKM 158.6), Heart (RPKM 127.5) and 9 other tissues See more
Orthologs
See Mtor in Genome Data Viewer
Location:
5q36
Exon count:
58
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (165263813..165373967)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 5 NC_005104.3 (168920414..169030568)

Chromosome 5 - NC_005104.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551951 Neighboring gene UbiA prenyltransferase domain containing 1 Neighboring gene angiopoietin-related protein 7-like Neighboring gene 40S ribosomal protein S2-like Neighboring gene exosome component 10 Neighboring gene spermidine synthase

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase III type 1 promoter DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase III type 1 promoter DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase III type 2 promoter DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase III type 2 promoter DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase III type 3 promoter DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase III type 3 promoter DNA binding ISO
Inferred from Sequence Orthology
more info
 
TFIIIC-class transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
TFIIIC-class transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kinase activity ISO
Inferred from Sequence Orthology
more info
 
phosphoprotein binding IEA
Inferred from Electronic Annotation
more info
 
phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
ribosome binding IEA
Inferred from Electronic Annotation
more info
 
ribosome binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
'de novo' pyrimidine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
'de novo' pyrimidine nucleobase biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
T-helper 1 cell lineage commitment ISO
Inferred from Sequence Orthology
more info
 
TOR signaling ISO
Inferred from Sequence Orthology
more info
 
TORC1 signaling IEA
Inferred from Electronic Annotation
more info
 
TORC1 signaling ISO
Inferred from Sequence Orthology
more info
 
brain development IEP
Inferred from Expression Pattern
more info
PubMed 
cardiac cell development ISO
Inferred from Sequence Orthology
more info
 
cardiac muscle cell development IEA
Inferred from Electronic Annotation
more info
 
cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
 
cardiac muscle contraction IEA
Inferred from Electronic Annotation
more info
 
cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
cardiac muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
cell aging IEP
Inferred from Expression Pattern
more info
PubMed 
cell projection organization IGI
Inferred from Genetic Interaction
more info
PubMed 
cell projection organization ISO
Inferred from Sequence Orthology
more info
 
cellular response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
 
cellular response to amino acid stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
cellular response to hypoxia ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to leucine IEA
Inferred from Electronic Annotation
more info
 
cellular response to leucine ISO
Inferred from Sequence Orthology
more info
 
cellular response to leucine starvation IEA
Inferred from Electronic Annotation
more info
 
cellular response to leucine starvation ISO
Inferred from Sequence Orthology
more info
 
cellular response to nutrient levels ISO
Inferred from Sequence Orthology
more info
 
cellular response to nutrient levels ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to starvation ISO
Inferred from Sequence Orthology
more info
 
energy reserve metabolic process IEA
Inferred from Electronic Annotation
more info
 
energy reserve metabolic process ISO
Inferred from Sequence Orthology
more info
 
germ cell development IEA
Inferred from Electronic Annotation
more info
 
germ cell development ISO
Inferred from Sequence Orthology
more info
 
heart morphogenesis IEA
Inferred from Electronic Annotation
more info
 
heart morphogenesis ISO
Inferred from Sequence Orthology
more info
 
heart valve morphogenesis IEA
Inferred from Electronic Annotation
more info
 
heart valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
long-term memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
maternal process involved in female pregnancy IDA
Inferred from Direct Assay
more info
PubMed 
multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
negative regulation of autophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of calcineurin-NFAT signaling cascade IEA
Inferred from Electronic Annotation
more info
 
negative regulation of calcineurin-NFAT signaling cascade ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell size IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell size ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cholangiocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of iodide transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of macroautophagy IEA
Inferred from Electronic Annotation
more info
 
negative regulation of macroautophagy ISO
Inferred from Sequence Orthology
more info
 
negative regulation of muscle atrophy IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-threonine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell growth involved in cardiac muscle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cholangiocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of dendritic spine development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of eating behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epithelial to mesenchymal transition IEA
Inferred from Electronic Annotation
more info
 
positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of granulosa cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of keratinocyte migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of keratinocyte migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of lamellipodium assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of lipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of myotube differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of myotube differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of skeletal muscle hypertrophy IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of stress fiber assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase III IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase III ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription of nucleolar large rRNA by RNA polymerase I IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription of nucleolar large rRNA by RNA polymerase I ISO
Inferred from Sequence Orthology
more info
 
positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of translation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of wound healing, spreading of epidermal cells IEA
Inferred from Electronic Annotation
more info
 
positive regulation of wound healing, spreading of epidermal cells ISO
Inferred from Sequence Orthology
more info
 
post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
post-embryonic development ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
regulation of brown fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of carbohydrate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of carbohydrate metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of carbohydrate utilization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of carbohydrate utilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
regulation of cell size ISO
Inferred from Sequence Orthology
more info
 
regulation of fatty acid beta-oxidation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of fatty acid beta-oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of glycogen biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of glycogen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of membrane permeability IEA
Inferred from Electronic Annotation
more info
 
regulation of membrane permeability ISO
Inferred from Sequence Orthology
more info
 
regulation of myelination IEA
Inferred from Electronic Annotation
more info
 
regulation of myelination ISO
Inferred from Sequence Orthology
more info
 
regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
regulation of osteoclast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of response to food IDA
Inferred from Direct Assay
more info
PubMed 
regulation of response to food IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
response to amino acid ISO
Inferred from Sequence Orthology
more info
 
response to cocaine IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to insulin IEA
Inferred from Electronic Annotation
more info
 
response to insulin ISO
Inferred from Sequence Orthology
more info
 
response to morphine IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to nutrient IEA
Inferred from Electronic Annotation
more info
 
response to nutrient ISO
Inferred from Sequence Orthology
more info
 
ruffle organization IEA
Inferred from Electronic Annotation
more info
 
ruffle organization ISO
Inferred from Sequence Orthology
more info
 
social behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
spinal cord development IDA
Inferred from Direct Assay
more info
PubMed 
visual learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
voluntary musculoskeletal movement IEA
Inferred from Electronic Annotation
more info
 
voluntary musculoskeletal movement ISO
Inferred from Sequence Orthology
more info
 
wound healing IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with PML body ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with PML body ISS
Inferred from Sequence or Structural Similarity
more info
 
TORC1 complex IDA
Inferred from Direct Assay
more info
PubMed 
TORC1 complex ISO
Inferred from Sequence Orthology
more info
 
TORC2 complex IEA
Inferred from Electronic Annotation
more info
 
TORC2 complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with dendrite IDA
Inferred from Direct Assay
more info
PubMed 
dendrite ISO
Inferred from Sequence Orthology
more info
 
endomembrane system ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
lysosome ISO
Inferred from Sequence Orthology
more info
 
lysosome ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
serine/threonine-protein kinase mTOR
Names
FK506 binding protein 12-rapamycin associated protein 1
FK506-binding protein 12-rapamycin complex-associated protein 1
FKBP12-rapamycin complex-associated protein
RAPT1
mammalian target of rapamycin
mechanistic target of rapamycin (serine/threonine kinase)
rapamycin and FKBP12 target-1 protein
rapamycin target protein 1
NP_063971.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019906.1NP_063971.1  serine/threonine-protein kinase mTOR

    See identical proteins and their annotated locations for NP_063971.1

    Status: PROVISIONAL

    Source sequence(s)
    U11681
    UniProtKB/Swiss-Prot
    P42346
    Related
    ENSRNOP00000014167.4, ENSRNOT00000014167.7
    Conserved Domains (6) summary
    COG5032
    Location:3632549
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05169
    Location:21532431
    PIKKc_TOR; Catalytic domain of Target of Rapamycin
    pfam02260
    Location:25182549
    FATC; FATC domain
    pfam08771
    Location:20152112
    Rapamycin_bind; Rapamycin binding domain
    pfam11865
    Location:8541024
    DUF3385; Domain of unknown function (DUF3385)
    sd00044
    Location:655681
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005104.4 Reference Rnor_6.0 Primary Assembly

    Range
    165263813..165373967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000073.1 Alternate Rn_Celera

    Range
    157161454..157270899
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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