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Pigo phosphatidylinositol glycan anchor biosynthesis, class O [ Mus musculus (house mouse) ]

Gene ID: 56703, updated on 26-Sep-2022

Summary

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Official Symbol
Pigoprovided by MGI
Official Full Name
phosphatidylinositol glycan anchor biosynthesis, class Oprovided by MGI
Primary source
MGI:MGI:1861452
See related
Ensembl:ENSMUSG00000028454 AllianceGenome:MGI:1861452
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PIG-O
Summary
Predicted to enable mannose-ethanolamine phosphotransferase activity. Involved in GPI anchor biosynthetic process. Located in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and skeleton. Orthologous to human PIGO (phosphatidylinositol glycan anchor biosynthesis class O). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 11.6), duodenum adult (RPKM 11.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Pigo in Genome Data Viewer
Location:
4; 4 A5
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (43017626..43026374, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (43017626..43027696, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene valosin containing protein Neighboring gene Fanconi anemia, complementation group G Neighboring gene stomatin (Epb7.2)-like 2 Neighboring gene atos homolog B Neighboring gene unc-13 homolog B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Requirement of PIG-F and PIG-O for transferring phosphoethanolamine to the third mannose in glycosylphosphatidylinositol. Hong Y, et al. J Biol Chem, 2000 Jul 7. PMID 10781593
  2. GPI7 is the second partner of PIG-F and involved in modification of glycosylphosphatidylinositol. Shishioh N, et al. J Biol Chem, 2005 Mar 11. PMID 15632136
  3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (20) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • FLJ00350, mFLJ00350

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mannose-ethanolamine phosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables mannose-ethanolamine phosphotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphotransferase activity, for other substituted phosphate groups TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity, transferring phosphorus-containing groups IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in GPI anchor biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GPI ethanolamine phosphate transferase 3
Names
phosphatidylinositol-glycan biosynthesis class O protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305386.1 → NP_001292315.1  GPI ethanolamine phosphate transferase 3 isoform 2

    See identical proteins and their annotated locations for NP_001292315.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AK050819, AL672276, BC092394, BU708685
    UniProtKB/TrEMBL
    Q562G0
    Conserved Domains (1) summary
    cd16023
    Location:64 → 344
    GPI_EPT_3; GPI ethanolamine phosphate transferase 3, PIG-O

  2. NM_001305387.1 → NP_001292316.1  GPI ethanolamine phosphate transferase 3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, uses a downstream start codon, and uses an alternate in-frame splice site in 3' coding region compared to variant 1. The encoded isoform (3) has a shorter N-terminus and lacks an internal segment compared to isoform 1.
    Source sequence(s)
    BC092394, BU708685, BY130204, CF532064
    Consensus CDS
    CCDS84720.1
    UniProtKB/TrEMBL
    A2AG36, Q562G0
    Related
    ENSMUSP00000069749.6, ENSMUST00000067481.6
    Conserved Domains (2) summary
    COG1524
    Location:42 → 433
    Npp1; Predicted pyrophosphatase or phosphodiesterase, AlkP superfamily [General function prediction only]
    cd16023
    Location:64 → 344
    GPI_EPT_3; GPI ethanolamine phosphate transferase 3, PIG-O

  3. NM_020035.3 → NP_064419.2  GPI ethanolamine phosphate transferase 3 isoform 1

    See identical proteins and their annotated locations for NP_064419.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC092394, BU708685
    Consensus CDS
    CCDS18088.1
    UniProtKB/TrEMBL
    Q562G0
    Related
    ENSMUSP00000095713.3, ENSMUST00000098109.9
    Conserved Domains (2) summary
    COG1524
    Location:50 → 441
    Npp1; Predicted pyrophosphatase or phosphodiesterase, AlkP superfamily [General function prediction only]
    cd16023
    Location:72 → 352
    GPI_EPT_3; GPI ethanolamine phosphate transferase 3, PIG-O

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    43017626..43026374 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538113.4 → XP_006538176.1  GPI ethanolamine phosphate transferase 3 isoform X1

    See identical proteins and their annotated locations for XP_006538176.1

    Conserved Domains (1) summary
    cd16023
    Location:64 → 344
    GPI_EPT_3; GPI ethanolamine phosphate transferase 3, PIG-O

  2. XM_030253685.2 → XP_030109545.1  GPI ethanolamine phosphate transferase 3 isoform X2

    Conserved Domains (1) summary
    cl23718
    Location:1 → 65
    ALP_like; alkaline phosphatases and sulfatases

RNA

  1. XR_390332.3 RNA Sequence

  2. XR_004941938.1 RNA Sequence

  3. XR_004941937.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JJI6.2 GenPept UniProtKB/Swiss-Prot:Q9JJI6

Gene LinkOut

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