bub1bb BUB1 mitotic checkpoint serine/threonine kinase Bb [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: bub1bbprovided by ZNC
Official Full Name: BUB1 mitotic checkpoint serine/threonine kinase Bbprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030829-51
See related: Ensembl:ENSDARG00000074927 AllianceGenome:ZFIN:ZDB-GENE-030829-51
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sb:cb730
Summary: Predicted to enable kinase activity. Predicted to act upstream of or within mitotic spindle assembly checkpoint signaling and phosphorylation. Is expressed in hindbrain; optic tectum; pectoral fin musculature; proliferative region; and retina. Human ortholog(s) of this gene implicated in colorectal cancer and mosaic variegated aneuploidy syndrome 1. Orthologous to human BUB1B (BUB1 mitotic checkpoint serine/threonine kinase B). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 17

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	17	NC_133192.1 (3139711..3160796)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (2127009..2148106)

Chromosome 17 - NC_133192.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in mitotic spindle assembly checkpoint signaling	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mitotic checkpoint serine/threonine-protein kinase BUB1 beta

Names: budding uninhibited by benzimidazoles 1 homolog beta b

XP_695384.3

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001442448.1 → NP_001429377.1 mitotic checkpoint serine/threonine-protein kinase BUB1 beta

Status: VALIDATED

Source sequence(s)

JBMGRA010000017

UniProtKB/TrEMBL

A0A8N7T876, E7F5T9