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Lamtor3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [ Mus musculus (house mouse) ]

Gene ID: 56692, updated on 27-Nov-2024

Summary

Official Symbol
Lamtor3provided by MGI
Official Full Name
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3provided by MGI
Primary source
MGI:MGI:1929467
See related
Ensembl:ENSMUSG00000091512 AllianceGenome:MGI:1929467
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mp1; Mapbp; Mapksp1; Map2k1ip1
Summary
Enables kinase activator activity. Acts upstream of or within positive regulation of MAPK cascade and protein localization to cell junction. Located in late endosome. Is expressed in several structures, including central nervous system; genitourinary system; and retina. Orthologous to human LAMTOR3 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 27.6), placenta adult (RPKM 23.6) and 28 other tissues See more
Orthologs
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Genomic context

See Lamtor3 in Genome Data Viewer
Location:
3 G3; 3 63.97 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (137624316..137634523)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (137918555..137928762)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09095 Neighboring gene DnaJ heat shock protein family (Hsp40) member B14 Neighboring gene predicted gene, 40155 Neighboring gene STARR-positive B cell enhancer ABC_E9081 Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene dual adaptor for phosphotyrosine and 3-phosphoinositides 1 Neighboring gene STARR-positive B cell enhancer ABC_E9226 Neighboring gene predicted gene, 19708 Neighboring gene STARR-seq mESC enhancer starr_09102 Neighboring gene STARR-positive B cell enhancer ABC_E6138 Neighboring gene STARR-positive B cell enhancer ABC_E3472 Neighboring gene STARR-positive B cell enhancer ABC_E1268 Neighboring gene STARR-positive B cell enhancer mm9_chr3:137680066-137680366 Neighboring gene RIKEN cDNA 1110002E22 gene Neighboring gene predicted gene 5105

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC103121

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to molecular adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in TORC1 signaling NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cellular response to amino acid stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to amino acid stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to amino acid stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of TOR signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of TORC1 signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within protein localization to cell junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of FNIP-folliculin RagC/D GAP IEA
Inferred from Electronic Annotation
more info
 
part_of FNIP-folliculin RagC/D GAP ISO
Inferred from Sequence Orthology
more info
 
part_of Ragulator complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Ragulator complex ISO
Inferred from Sequence Orthology
more info
 
part_of Ragulator complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in late endosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in late endosome IPI
Inferred from Physical Interaction
more info
PubMed 
located_in late endosome membrane NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in lysosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in lysosomal membrane NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
ragulator complex protein LAMTOR3
Names
MAPK scaffold protein 1
MEK binding partner 1
late endosomal/lysosomal adaptor and MAPK and MTOR activator 3
mitogen activated protein, binding protein
mitogen-activated protein kinase kinase 1-interacting protein 1
mitogen-activated protein kinase scaffold protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019920.2NP_064304.1  ragulator complex protein LAMTOR3

    See identical proteins and their annotated locations for NP_064304.1

    Status: PROVISIONAL

    Source sequence(s)
    AC146607
    Consensus CDS
    CCDS51078.1
    UniProtKB/Swiss-Prot
    O88653
    UniProtKB/TrEMBL
    Q3TX23, Q542I7
    Related
    ENSMUSP00000130811.2, ENSMUST00000168345.6
    Conserved Domains (1) summary
    pfam08923
    Location:3121
    MAPKK1_Int; Mitogen-activated protein kinase kinase 1 interacting

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    137624316..137634523
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)