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PSG1 pregnancy specific beta-1-glycoprotein 1 [ Homo sapiens (human) ]

Gene ID: 5669, updated on 8-Jul-2021

Summary

Official Symbol
PSG1provided by HGNC
Official Full Name
pregnancy specific beta-1-glycoprotein 1provided by HGNC
Primary source
HGNC:HGNC:9514
See related
Ensembl:ENSG00000231924 MIM:176390
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SP1; B1G1; PBG1; CD66f; PSBG1; PSG95; PSGGA; DHFRP2; PSBG-1; PSGIIA; FL-NCA-1/2; PS-beta-C/D; PS-beta-G-1
Summary
The human placenta is a multihormonal endocrine organ that produces hormones, enzymes, and other molecules that support fetal survival and development. Pregnancy-specific beta-1-glycoprotein (PSBG, PSG) is a major product of the syncytiotrophoblast, reaching concentrations of 100 to 290 mg/l at term in the serum of pregnant women (Horne et al., 1976 [PubMed 971765]). PSG is a member of the immunoglobulin (Ig) superfamily (Watanabe and Chou, 1988 [PubMed 3257488]; Streydio et al., 1988 [PubMed 3260773]).[supplied by OMIM, Oct 2009]
Expression
Restricted expression toward placenta (RPKM 224.3) See more
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Genomic context

See PSG1 in Genome Data Viewer
Location:
19q13.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (42866464..42879713, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (43370616..43383865, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene PSG8 antisense RNA 1 Neighboring gene pregnancy specific beta-1-glycoprotein 10, pseudogene Neighboring gene pregnancy specific beta-1-glycoprotein 6 Neighboring gene pregnancy specific beta-1-glycoprotein 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ90598, FLJ90654

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in female pregnancy TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
pregnancy-specific beta-1-glycoprotein 1
Names
CD66 antigen-like family member F
fetal liver non-specific cross-reactive antigen 1/2
pregnancy-specific B-1 glycoprotein
pregnancy-specific beta-1 glycoprotein C/D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001184825.2NP_001171754.1  pregnancy-specific beta-1-glycoprotein 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001171754.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 3' terminal exon, compared to variant 4. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 4.
    Source sequence(s)
    AC005238
    Consensus CDS
    CCDS54275.1
    UniProtKB/Swiss-Prot
    P11464
    Related
    ENSP00000413041.2, ENST00000436291.7
    Conserved Domains (3) summary
    pfam13895
    Location:335413
    Ig_2; Immunoglobulin domain
    cd05774
    Location:36138
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cl11960
    Location:148236
    Ig; Immunoglobulin domain
  2. NM_001184826.2NP_001171755.1  pregnancy-specific beta-1-glycoprotein 1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001171755.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 3' terminal exon, compared to variant 4. It encodes isoform 3, which has a shorter and distinct C-terminus, compared to isoform 4.
    Source sequence(s)
    AC005238
    Consensus CDS
    CCDS59392.1
    UniProtKB/Swiss-Prot
    P11464
    Related
    ENSP00000472610.1, ENST00000595356.5
    Conserved Domains (4) summary
    cd05774
    Location:36138
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:339413
    IG_like; Immunoglobulin like
    pfam13895
    Location:335413
    Ig_2; Immunoglobulin domain
    cl11960
    Location:148236
    Ig; Immunoglobulin domain
  3. NM_001297773.2NP_001284702.1  pregnancy-specific beta-1-glycoprotein 1 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001284702.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (4).
    Source sequence(s)
    AC005238, M20879
    Consensus CDS
    CCDS74380.1
    UniProtKB/Swiss-Prot
    P11464
    Related
    ENSP00000308970.6, ENST00000312439.10
    Conserved Domains (4) summary
    cd05774
    Location:36138
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:339413
    IG_like; Immunoglobulin like
    pfam13895
    Location:335413
    Ig_2; Immunoglobulin domain
    cl11960
    Location:148236
    Ig; Immunoglobulin domain
  4. NM_001330524.2NP_001317453.1  pregnancy-specific beta-1-glycoprotein 1 isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AC005238, DA829309
    Consensus CDS
    CCDS82360.1
    UniProtKB/TrEMBL
    G5E9F7
    Related
    ENSP00000385386.3, ENST00000403380.7
    Conserved Domains (4) summary
    cd05774
    Location:36138
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:246320
    IG_like; Immunoglobulin like
    pfam13895
    Location:242320
    Ig_2; Immunoglobulin domain
    cl11960
    Location:148236
    Ig; Immunoglobulin domain
  5. NM_006905.3NP_008836.2  pregnancy-specific beta-1-glycoprotein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_008836.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses alternate splice sites in the 3' terminal exon, compared to variant 4. It encodes isoform 1, which has a shorter and distinct C-terminus, compared to isoform 4.
    Source sequence(s)
    AC005238, BC022338
    Consensus CDS
    CCDS12612.1
    UniProtKB/Swiss-Prot
    P11464
    Related
    ENSP00000244296.2, ENST00000244296.6
    Conserved Domains (4) summary
    cd05774
    Location:36138
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:339413
    IG_like; Immunoglobulin like
    pfam13895
    Location:335413
    Ig_2; Immunoglobulin domain
    cl11960
    Location:148236
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    42866464..42879713 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259065.4XP_005259122.1  pregnancy-specific beta-1-glycoprotein 1 isoform X1

    Conserved Domains (4) summary
    cd05774
    Location:36138
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:246320
    IG_like; Immunoglobulin like
    pfam13895
    Location:242320
    Ig_2; Immunoglobulin domain
    cl11960
    Location:148236
    Ig; Immunoglobulin domain
  2. XM_011527125.2XP_011525427.1  pregnancy-specific beta-1-glycoprotein 1 isoform X2

    See identical proteins and their annotated locations for XP_011525427.1

    UniProtKB/TrEMBL
    O75238
    Conserved Domains (4) summary
    cd05774
    Location:36138
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:246320
    IG_like; Immunoglobulin like
    pfam13895
    Location:242320
    Ig_2; Immunoglobulin domain
    cl11960
    Location:148236
    Ig; Immunoglobulin domain
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