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pot1 protection of telomeres 1 homolog [ Danio rerio (zebrafish) ]

Gene ID: 566847, updated on 27-Mar-2024

Summary

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Official Symbol
pot1provided by ZNC
Official Full Name
protection of telomeres 1 homologprovided by ZNC
Primary source
ZFIN:ZDB-GENE-110324-1
See related
Ensembl:ENSDARG00000079915 AllianceGenome:ZFIN:ZDB-GENE-110324-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable G-rich strand telomeric DNA binding activity and telomerase inhibitor activity. Predicted to be involved in negative regulation of telomerase activity; regulation of telomere maintenance via telomerase; and telomere capping. Predicted to act upstream of or within telomere maintenance. Predicted to be located in chromosome, telomeric region and nucleus. Predicted to be part of nuclear telomere cap complex. Is expressed in several structures, including gill; heart; liver; pleuroperitoneal region; and post-vent region. Human ortholog(s) of this gene implicated in familial melanoma and high grade glioma. Orthologous to human POT1 (protection of telomeres 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 25
Exon count:
22
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (27405777..27491918)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (26962574..27048715)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene glutamate receptor, metabotropic 8b Neighboring gene uncharacterized LOC110438395 Neighboring gene uncharacterized LOC103909868 Neighboring gene G protein-coupled receptor 37a Neighboring gene sperm adhesion molecule 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish as a model system to study the physiological function of telomeric protein TPP1. Xie Y, et al. PLoS One, 2011 Feb 2. PMID 21311760, Free PMC Article
  2. The knockdown efficiency of telomere associated genes with specific methodology in a zebrafish cell line. Hu X, et al. Biochimie, 2021 Nov. PMID 34214617
  3. Knockout of Shelterin subunit genes in zebrafish results in distinct outcomes. Ma J, et al. Biochem Biophys Res Commun, 2022 Aug 20. PMID 35667242
  4. The differential spatiotemporal expression pattern of shelterin genes throughout lifespan. Wagner KD, et al. Aging (Albany NY), 2017 Apr. PMID 28437249, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables G-rich strand telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded telomeric DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables telomerase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of telomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of telomere maintenance via telomerase IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in telomere capping IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within telomere maintenance IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear telomere cap complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protection of telomeres protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001245960.1 → NP_001232889.1  protection of telomeres protein 1

    See identical proteins and their annotated locations for NP_001232889.1

    Status: PROVISIONAL

    Source sequence(s)
    HQ652076
    UniProtKB/TrEMBL
    F1D6H6
    Related
    ENSDARP00000129477.1, ENSDART00000154362.2
    Conserved Domains (2) summary
    cd04497
    Location:151 → 283
    hPOT1_OB1_like; hPOT1_OB1_like: A subfamily of OB folds similar to the first OB fold (OB1) of human protection of telomeres 1 protein (hPOT1), the single OB fold of the N-terminal domain of Schizosaccharomyces pombe POT1 (SpPOT1), and the first OB fold of the N-terminal ...
    pfam16686
    Location:295 → 438
    POT1PC; ssDNA-binding domain of telomere protection protein

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    27405777..27491918
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005163119.4 → XP_005163176.1  protection of telomeres protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BA64, E7F0D5
    Related
    ENSDARP00000102969.2, ENSDART00000115139.5
    Conserved Domains (2) summary
    cd04497
    Location:151 → 283
    hPOT1_OB1_like; hPOT1_OB1_like: A subfamily of OB folds similar to the first OB fold (OB1) of human protection of telomeres 1 protein (hPOT1), the single OB fold of the N-terminal domain of Schizosaccharomyces pombe POT1 (SpPOT1), and the first OB fold of the N-terminal ...
    pfam16686
    Location:295 → 438
    POT1PC; ssDNA-binding domain of telomere protection protein

  2. XM_021470509.1 → XP_021326184.1  protection of telomeres protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PMS4
    Related
    ENSDARP00000145879.1, ENSDART00000183266.1
    Conserved Domains (2) summary
    cd04497
    Location:151 → 283
    hPOT1_OB1_like; A subfamily of OB folds similar to the first OB fold (OB1) of human protection of telomeres 1 protein (hPOT1), the single OB fold of the N-terminal domain of Schizosaccharomyces pombe POT1 (SpPOT1), and the first OB fold of the N-terminal domain of the ...
    pfam16686
    Location:295 → 438
    POT1PC; ssDNA-binding domain of telomere protection protein

  3. XM_021470510.1 → XP_021326185.1  protection of telomeres protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8M9PYF2
    Conserved Domains (2) summary
    cd04497
    Location:151 → 283
    hPOT1_OB1_like; A subfamily of OB folds similar to the first OB fold (OB1) of human protection of telomeres 1 protein (hPOT1), the single OB fold of the N-terminal domain of Schizosaccharomyces pombe POT1 (SpPOT1), and the first OB fold of the N-terminal domain of the ...
    pfam16686
    Location:295 → 438
    POT1PC; ssDNA-binding domain of telomere protection protein

  4. XM_021470511.1 → XP_021326186.1  protection of telomeres protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8M9PUZ9
    Conserved Domains (2) summary
    cd04497
    Location:25 → 157
    hPOT1_OB1_like; A subfamily of OB folds similar to the first OB fold (OB1) of human protection of telomeres 1 protein (hPOT1), the single OB fold of the N-terminal domain of Schizosaccharomyces pombe POT1 (SpPOT1), and the first OB fold of the N-terminal domain of the ...
    pfam16686
    Location:169 → 312
    POT1PC; ssDNA-binding domain of telomere protection protein
Nucleotide Protein
Heading Accession and Version

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