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AKIP1 A-kinase interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 56672, updated on 9-Sep-2018

Summary

Official Symbol
AKIP1provided by HGNC
Official Full Name
A-kinase interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:1170
See related
Ensembl:ENSG00000166452 MIM:609191; Vega:OTTHUMG00000165653
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BCA3; C11orf17
Summary
This gene encodes a nuclear protein that interacts with protein kinase A catalytic subunit, and regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in thyroid (RPKM 4.3), adrenal (RPKM 4.1) and 25 other tissues See more
Orthologs

Genomic context

See AKIP1 in Genome Data Viewer
Location:
11p15.4
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (8911117..8920079)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (8932701..8941626)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene suppression of tumorigenicity 5 Neighboring gene uncharacterized LOC105376539 Neighboring gene uncharacterized LOC102724784 Neighboring gene RNA, 5S ribosomal pseudogene 330 Neighboring gene chromosome 11 open reading frame 16 Neighboring gene achaete-scute family bHLH transcription factor 3 Neighboring gene TMEM9 domain family member B Neighboring gene TMEM9B antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol HIV-1 PR(D25N) directly interacts with BCA3 in cells and co-localizes with BCA3 in the cytoplasm, particularly at the mitochondria PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of NIK/NF-kappaB signaling IEA
Inferred from Electronic Annotation
more info
 
substrate adhesion-dependent cell spreading IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
A-kinase-interacting protein 1
Names
A kinase (PRKA) interacting protein 1
breast cancer associated gene 3
koyt binding protein 1
koyt binding protein 2
koyt binding protein 3
proline-rich protein BCA3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030417.1 RefSeqGene

    Range
    5001..13926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001206646.1NP_001193575.1  A-kinase-interacting protein 1 isoform b

    See identical proteins and their annotated locations for NP_001193575.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon in the 5' region compared to variant 1. This results in a shorter isoform (b) missing an internal protein segment compared to isoform a. Note, isoforms b and c are the same length, but have different sequences.
    Source sequence(s)
    AF493785, DB570956
    Consensus CDS
    CCDS55744.1
    UniProtKB/Swiss-Prot
    Q9NQ31
    Related
    ENSP00000299576.5, OTTHUMP00000230630, ENST00000299576.9, OTTHUMT00000385614
  2. NM_001206647.1NP_001193576.1  A-kinase-interacting protein 1 isoform c

    See identical proteins and their annotated locations for NP_001193576.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame coding exon in the 3' region compared to variant 1. This results in a shorter isoform (c) missing an internal protein segment compared to isoform a. Note, isoforms b and c are the same length, but have different sequences.
    Source sequence(s)
    AF493784, DB570956
    Consensus CDS
    CCDS55743.1
    UniProtKB/Swiss-Prot
    Q9NQ31
    Related
    ENSP00000310644.4, OTTHUMP00000230632, ENST00000309357.8, OTTHUMT00000385616
  3. NM_001206648.1NP_001193577.1  A-kinase-interacting protein 1 isoform d

    See identical proteins and their annotated locations for NP_001193577.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two in-frame coding exons compared to variant 1. This results in a shorter isoform (d) missing two internal protein segments compared to isoform a.
    Source sequence(s)
    AF493783, AW340643, DB570956
    UniProtKB/Swiss-Prot
    Q9NQ31
    Related
    ENSP00000431602.1, OTTHUMP00000230640, ENST00000529942.1, OTTHUMT00000385624
    Conserved Domains (1) summary
    COG1470
    Location:114153
    COG1470; Uncharacterized membrane protein [Function unknown]
  4. NM_020642.3NP_065693.2  A-kinase-interacting protein 1 isoform a

    See identical proteins and their annotated locations for NP_065693.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC026894, AF493783
    Consensus CDS
    CCDS7793.1
    UniProtKB/Swiss-Prot
    Q9NQ31
    Related
    ENSP00000310459.4, OTTHUMP00000230631, ENST00000309377.8, OTTHUMT00000385615

RNA

  1. NR_045417.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs at the 5' end compared to variant 1. It is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with the translation of the longer downstream ORF; translation of the upstream ORF renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF493783, BC030996, BP355293
  2. NR_045418.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs at the 5' end and lacks an exon in the 3' region compared to variant 1. It is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with the translation of the longer downstream ORF; translation of the upstream ORF renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF493783, BC030996, BM706322, BP355293

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    8911117..8920079
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018012.2XP_016873501.1  A-kinase-interacting protein 1 isoform X2

    UniProtKB/TrEMBL
    E9PN38
    Related
    ENSP00000434726.1, OTTHUMP00000230633, ENST00000529876.5
  2. XM_017018011.1XP_016873500.1  A-kinase-interacting protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9NQ31
    Conserved Domains (1) summary
    COG1470
    Location:168207
    COG1470; Uncharacterized membrane protein [Function unknown]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001206645.1: Suppressed sequence

    Description
    NM_001206645.1: This RefSeq was permanently suppressed because it contains an upstream open reading frame with a strong Kozak signal, use of which will render this transcript a candidate for nonsense-mediated mRNA decay (NMD).
  2. NM_182901.3: Suppressed sequence

    Description
    NM_182901.3: This RefSeq was permanently suppressed because it contains an upstream open reading frame with a strong Kozak signal, use of which will render this transcript a candidate for nonsense-mediated mRNA decay (NMD).
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