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SUCNR1 succinate receptor 1 [ Homo sapiens (human) ]

Gene ID: 56670, updated on 23-Nov-2021

Summary

Official Symbol
SUCNR1provided by HGNC
Official Full Name
succinate receptor 1provided by HGNC
Primary source
HGNC:HGNC:4542
See related
Ensembl:ENSG00000198829 MIM:606381
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPR91
Summary
This gene encodes a G-protein-coupled receptor for succinate, an intermediate molecule of the citric acid cycle. It is involved in the promotion of hematopoietic progenitor cell development, and it has a potential role in renovascular hypertension which has known correlations to renal failure, diabetes and atherosclerosis. [provided by RefSeq, Oct 2009]
Expression
Biased expression in kidney (RPKM 20.6), thyroid (RPKM 7.3) and 7 other tissues See more
Orthologs
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Genomic context

See SUCNR1 in Genome Data Viewer
Location:
3q25.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (151873643..151884619)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (151591431..151602407)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene AADACL2 antisense RNA 1 Neighboring gene uncharacterized LOC105374160 Neighboring gene arylacetamide deacetylase Neighboring gene uncharacterized LOC105374159 Neighboring gene uncharacterized LOC107986047

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in macrophage activation involved in immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of angiotensin metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in renin secretion into blood stream IEA
Inferred from Electronic Annotation
more info
 
involved_in response to calcium ion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
succinate receptor 1
Names
G-protein coupled receptor 91
P2Y purinoceptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033050.6NP_149039.2  succinate receptor 1

    See identical proteins and their annotated locations for NP_149039.2

    Status: REVIEWED

    Source sequence(s)
    AC068647, AK290420, BP394710, BX093329
    Consensus CDS
    CCDS3162.1
    UniProtKB/Swiss-Prot
    Q9BXA5
    Related
    ENSP00000355156.4, ENST00000362032.6
    Conserved Domains (1) summary
    cd15378
    Location:24306
    7tmA_SUCNR1_GPR91; succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    151873643..151884619
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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