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MUC13 mucin 13, cell surface associated [ Homo sapiens (human) ]

Gene ID: 56667, updated on 20-Apr-2020

Summary

Official Symbol
MUC13provided by HGNC
Official Full Name
mucin 13, cell surface associatedprovided by HGNC
Primary source
HGNC:HGNC:7511
See related
Ensembl:ENSG00000173702 MIM:612181
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRCC1; MUC-13
Summary
Epithelial mucins, such as MUC13, are a family of secreted and cell surface glycoproteins expressed by ductal and glandular epithelial tissues (Williams et al., 2001 [PubMed 11278439]).[supplied by OMIM, Jul 2008]
Expression
Biased expression in duodenum (RPKM 317.3), small intestine (RPKM 271.9) and 4 other tissues See more
Orthologs

Genomic context

See MUC13 in Genome Data Viewer
Location:
3q21.2
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (124905442..124934751, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (124624289..124653595, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein S26 pseudogene 22 Neighboring gene uridine monophosphate synthetase Neighboring gene integrin subunit beta 5 Neighboring gene enolase 1 pseudogene 3 Neighboring gene heart development protein with EGF like domains 1 Neighboring gene Sharpr-MPRA regulatory region 1791 Neighboring gene RNA, 5S ribosomal pseudogene 137

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20063

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
O-glycan processing TAS
Traceable Author Statement
more info
 
maintenance of gastrointestinal epithelium IMP
Inferred from Mutant Phenotype
more info
PubMed 
stimulatory C-type lectin receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi lumen TAS
Traceable Author Statement
more info
 
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
mucin-13
Names
down-regulated in colon cancer 1
mucin 13, epithelial transmembrane

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033049.4NP_149038.3  mucin-13 precursor

    See identical proteins and their annotated locations for NP_149038.3

    Status: VALIDATED

    Source sequence(s)
    AB035807, AF286113, AK000070, DA428072
    Consensus CDS
    CCDS33839.2
    UniProtKB/Swiss-Prot
    Q9H3R2
    Related
    ENSP00000485028.1, ENST00000616727.4
    Conserved Domains (2) summary
    TIGR04561
    Location:419468
    membra_charge; integral membrane protein
    pfam01390
    Location:214313
    SEA; SEA domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    124905442..124934751 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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