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casp3b caspase 3, apoptosis-related cysteine peptidase b [ Danio rerio (zebrafish) ]

Gene ID: 566604, updated on 9-Sep-2025
Official Symbol
casp3bprovided by ZNC
Official Full Name
caspase 3, apoptosis-related cysteine peptidase bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070607-1
See related
Ensembl:ENSDARG00000055045 AllianceGenome:ZFIN:ZDB-GENE-070607-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
casp3l
Summary
Enables protein homodimerization activity. Predicted to be involved in several processes, including erythrocyte differentiation; keratinocyte differentiation; and positive regulation of neuron apoptotic process. Predicted to be part of death-inducing signaling complex. Predicted to be active in cytoplasm. Is expressed in female organism; intestine; muscle cell; nervous system; and pharyngeal arch. Human ortholog(s) of this gene implicated in Parkinson's disease; colon cancer; lung non-small cell carcinoma; and stomach cancer. Orthologous to human CASP3 (caspase 3). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
human mouse all
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See casp3b in Genome Data Viewer
Location:
chromosome: 14
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 14 NC_133189.1 (4620964..4654651, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 14 NC_007125.7 (4129369..4151254, complement)

Chromosome 14 - NC_133189.1Genomic Context describing neighboring genes Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 6 Neighboring gene interferon regulatory factor 2b Neighboring gene dehydrogenase/reductase (SDR family) member 13 like 1 Neighboring gene centromere protein U Neighboring gene solute carrier family 25 member 51b

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Phage display and structural studies reveal plasticity in substrate specificity of caspase-3a from zebrafish. Tucker MB, et al. Protein Sci, 2016 Nov. PMID 27577093, Free PMC Article
  2. Remodeling hydrogen bond interactions results in relaxed specificity of Caspase-3. Yao L, et al. Biosci Rep, 2021 Jan 29. PMID 33448281, Free PMC Article
  3. Induction of seizures and initiation of epileptogenesis by pilocarpine in zebrafish larvae. Gawel K, et al. Front Mol Neurosci, 2024. PMID 39165716, Free PMC Article
  4. Comparing the folding landscapes of evolutionarily divergent procaspase-3. Yao L, et al. Biosci Rep, 2022 Jun 30. PMID 35670809, Free PMC Article
  5. Silver nanoparticles induce oocyte maturation in zebrafish (Danio rerio). Chen SX, et al. Chemosphere, 2017 Mar. PMID 27974271, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables enzyme activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in erythrocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in execution phase of apoptosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in execution phase of apoptosis IEA
Inferred from Electronic Annotation
more info
  
involved_in keratinocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein maturation IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of death-inducing signaling complex IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
caspase-3b
Names
caspase 3, apoptosis-related cysteine protease b
caspase 3, apoptosis-related cysteine protease, like
NP_001041531.2
XP_005173133.1
XP_068069330.1
XP_073777626.1
XP_073777627.1
XP_073777629.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048066.2 → NP_001041531.2  caspase-3b

    Status: VALIDATED

    Source sequence(s)
    JBMGRA010000014
    UniProtKB/TrEMBL
    A0A8M2BKT2, F1Q7K7
    Related
    ENSDARP00000071815.4, ENSDART00000077348.6
    Conserved Domains (1) summary
    cd00032
    Location:47 → 284
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133189.1 Reference GRCz12tu Primary Assembly

    Range
    4620964..4654651 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073921525.1 → XP_073777626.1  caspase-3b isoform X1

  2. XM_005173076.6 → XP_005173133.1  caspase-3b isoform X2

    See identical proteins and their annotated locations for XP_005173133.1

    UniProtKB/TrEMBL
    A0A8M2BKT2, F1Q7K7
    Conserved Domains (1) summary
    cd00032
    Location:47 → 284
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

  3. XM_073921526.1 → XP_073777627.1  caspase-3b isoform X2

    UniProtKB/TrEMBL
    A0A8M2BKT2, F1Q7K7

  4. XM_073921528.1 → XP_073777629.1  caspase-3b isoform X3

  5. XM_068213229.2 → XP_068069330.1  caspase-3b isoform X2

    UniProtKB/TrEMBL
    A0A8M2BKT2, F1Q7K7
Nucleotide Protein Strain
Heading Accession and Version

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