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KCNK12 potassium two pore domain channel subfamily K member 12 [ Homo sapiens (human) ]

Gene ID: 56660, updated on 13-Mar-2020

Summary

Official Symbol
KCNK12provided by HGNC
Official Full Name
potassium two pore domain channel subfamily K member 12provided by HGNC
Primary source
HGNC:HGNC:6274
See related
Ensembl:ENSG00000184261 MIM:607366
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
THIK2; THIK-2; K2p12.1
Summary
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 1.7), placenta (RPKM 0.4) and 8 other tissues See more
Orthologs

Genomic context

See KCNK12 in Genome Data Viewer
Location:
2p16.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (47509290..47570985, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (47747914..47797470, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 119 Neighboring gene epithelial cell adhesion molecule Neighboring gene microRNA 559 Neighboring gene mutS homolog 2 Neighboring gene MSH2 overlapping transcript 1 Neighboring gene ribosomal protein L18a pseudogene 6 Neighboring gene uncharacterized LOC440864 Neighboring gene NME2 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of generalized vitiligo in an isolated European founder population identifies SMOC2, in close proximity to IDDM8.
NHGRI GWA Catalog

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
voltage-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
stabilization of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
potassium channel subfamily K member 12
Names
potassium channel, subfamily K, member 12
potassium channel, two pore domain subfamily K, member 12
tandem pore domain halothane-inhibited potassium channel 2
tandem pore domain potassium channel THIK-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022055.2NP_071338.1  potassium channel subfamily K member 12

    See identical proteins and their annotated locations for NP_071338.1

    Status: REVIEWED

    Source sequence(s)
    AC138655
    Consensus CDS
    CCDS1835.1
    UniProtKB/Swiss-Prot
    Q9HB15
    Related
    ENSP00000327611.3, ENST00000327876.5
    Conserved Domains (1) summary
    pfam07885
    Location:101169
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    47509290..47570985 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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