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KCNK13 potassium two pore domain channel subfamily K member 13 [ Homo sapiens (human) ]

Gene ID: 56659, updated on 8-Jul-2021


Official Symbol
KCNK13provided by HGNC
Official Full Name
potassium two pore domain channel subfamily K member 13provided by HGNC
Primary source
See related
Ensembl:ENSG00000152315 MIM:607367
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
THIK1; THIK-1; K2p13.1
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a potassium channel containing two pore-forming domains. This protein is an open channel that can be stimulated by arachidonic acid and inhibited by the anesthetic halothane. [provided by RefSeq, Jul 2013]
Biased expression in testis (RPKM 6.7), kidney (RPKM 2.6) and 6 other tissues See more
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Genomic context

See KCNK13 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (90061994..90185853)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (90528338..90652197)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene EF-hand calcium binding domain 11 Neighboring gene Sharpr-MPRA regulatory region 15055 Neighboring gene tyrosyl-DNA phosphodiesterase 1 Neighboring gene glutaredoxin pseudogene 2 Neighboring gene proteasome 26S subunit, ATPase 1 Neighboring gene NRDE-2, necessary for RNA interference, domain containing Neighboring gene uncharacterized LOC105370618 Neighboring gene ribosomal protein L21 pseudogene 11

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?


Associated conditions

Description Tests
Genetics of coronary artery calcification among African Americans, a meta-analysis.
GeneReviews: Not available
Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium.
GeneReviews: Not available

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
enables voltage-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
Process Evidence Code Pubs
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
involved_in regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
involved_in stabilization of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
Component Evidence Code Pubs
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
located_in plasma membrane TAS
Traceable Author Statement
more info

General protein information

Preferred Names
potassium channel subfamily K member 13
K2P13.1 potassium channel
potassium channel, subfamily K, member 13
potassium channel, two pore domain subfamily K, member 13
tandem pore domain halothane-inhibited potassium channel 1
tandem pore domain potassium channel THIK-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022054.4NP_071337.2  potassium channel subfamily K member 13

    See identical proteins and their annotated locations for NP_071337.2

    Status: REVIEWED

    Source sequence(s)
    AW117567, BC012779, EU978942
    Consensus CDS
    ENSP00000282146.4, ENST00000282146.5
    Conserved Domains (1) summary
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)
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