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OR2S2 olfactory receptor family 2 subfamily S member 2 [ Homo sapiens (human) ]

Gene ID: 56656, updated on 23-Nov-2023


Official Symbol
OR2S2provided by HGNC
Official Full Name
olfactory receptor family 2 subfamily S member 2provided by HGNC
Primary source
See related
Ensembl:ENSG00000278889 AllianceGenome:HGNC:8276
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR37A; OST715
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jul 2015]
Annotation information
Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
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Genomic context

See OR2S2 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (35957108..35958154, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (35978781..35979827, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (35957105..35958151, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:35910159-35911039 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19884 Neighboring gene small regulatory polypeptide of amino acid response Neighboring gene ReSE screen-validated silencer GRCh37_chr9:35917525-35917666 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:35923268-35924467 Neighboring gene phosphoglycerate mutase 1 pseudogene 2 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:35951260-35952459 Neighboring gene Y-box binding protein 1 pseudogene 10 Neighboring gene olfactory receptor family 13 subfamily C member 6 pseudogene

Genomic regions, transcripts, and products

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
enables olfactory receptor activity NAS
Non-traceable Author Statement
more info
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
involved_in detection of chemical stimulus involved in sensory perception of smell IBA
Inferred from Biological aspect of Ancestor
more info
involved_in sensory perception of smell NAS
Non-traceable Author Statement
more info
Component Evidence Code Pubs
located_in membrane NAS
Non-traceable Author Statement
more info
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
located_in plasma membrane TAS
Traceable Author Statement
more info

General protein information

Preferred Names
olfactory receptor 2S2
olfactory receptor OR9-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019897.2NP_063950.2  olfactory receptor 2S2

    See identical proteins and their annotated locations for NP_063950.2


    Source sequence(s)
    Consensus CDS
    Q2M3L0, Q6IF19, Q96R42, Q9NQN1
    ENSP00000344040.2, ENST00000341959.2
    Conserved Domains (1) summary
    7tmA_OR13-like; olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    35957108..35958154 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060933.1 Alternate T2T-CHM13v2.0

    35978781..35979827 complement
    GenBank, FASTA, Sequence Viewer (Graphics)