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POLE4 DNA polymerase epsilon 4, accessory subunit [ Homo sapiens (human) ]

Gene ID: 56655, updated on 1-Aug-2020

Summary

Official Symbol
POLE4provided by HGNC
Official Full Name
DNA polymerase epsilon 4, accessory subunitprovided by HGNC
Primary source
HGNC:HGNC:18755
See related
Ensembl:ENSG00000115350 MIM:607269
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p12; YHHQ1
Summary
POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]
Expression
Ubiquitous expression in fat (RPKM 27.9), bone marrow (RPKM 20.0) and 25 other tissues See more
Orthologs

Genomic context

See POLE4 in Genome Data Viewer
Location:
2p12
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (74958643..74970128)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (75185775..75196859)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1291 Neighboring gene uncharacterized LOC105374809 Neighboring gene long intergenic non-protein coding RNA 1293 Neighboring gene tachykinin receptor 1 Neighboring gene microRNA 5000 Neighboring gene uncharacterized LOC105374811 Neighboring gene uncharacterized LOC107985900

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with polymerase (DNA directed), epsilon 4 (POLE4) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-directed DNA polymerase activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
DNA replication initiation TAS
Traceable Author Statement
more info
 
G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
telomere maintenance via semi-conservative replication TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Ada2/Gcn5/Ada3 transcription activator complex IDA
Inferred from Direct Assay
more info
PubMed 
epsilon DNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
epsilon DNA polymerase complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
DNA polymerase epsilon subunit 4
Names
DNA polymerase II subunit 4
DNA polymerase epsilon subunit p12
polymerase (DNA) epsilon 4, accessory subunit
polymerase (DNA-directed), epsilon 4, accessory subunit
NP_063949.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019896.4NP_063949.2  DNA polymerase epsilon subunit 4

    See identical proteins and their annotated locations for NP_063949.2

    Status: VALIDATED

    Source sequence(s)
    AC007400, BC031331, BU594966
    Consensus CDS
    CCDS1957.1
    UniProtKB/Swiss-Prot
    Q9NR33
    Related
    ENSP00000420176.1, ENST00000483063.2
    Conserved Domains (1) summary
    cl23735
    Location:40103
    H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    74958643..74970128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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