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POLE4 DNA polymerase epsilon 4, accessory subunit [ Homo sapiens (human) ]

Gene ID: 56655, updated on 1-Oct-2024

Summary

Official Symbol
POLE4provided by HGNC
Official Full Name
DNA polymerase epsilon 4, accessory subunitprovided by HGNC
Primary source
HGNC:HGNC:18755
See related
Ensembl:ENSG00000115350 MIM:607269; AllianceGenome:HGNC:18755
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p12; YHHQ1
Summary
POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]
Expression
Ubiquitous expression in fat (RPKM 27.9), bone marrow (RPKM 20.0) and 25 other tissues See more
Orthologs
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Genomic context

See POLE4 in Genome Data Viewer
Location:
2p12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (74958643..74970128)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (74967499..74978982)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (75185770..75197255)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:75061972-75062848 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:75064008-75064523 Neighboring gene Sharpr-MPRA regulatory region 11570 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16083 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:75082772-75083312 Neighboring gene hexokinase 2 Neighboring gene uncharacterized LOC105374809 Neighboring gene long intergenic non-protein coding RNA 1291 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:75185356-75185856 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:75185857-75186357 Neighboring gene NANOG hESC enhancer GRCh37_chr2:75211079-75211580 Neighboring gene uncharacterized LOC124907850 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11678 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11679 Neighboring gene tachykinin receptor 1 Neighboring gene microRNA 5000

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with polymerase (DNA directed), epsilon 4 (POLE4) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-directed DNA polymerase activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA-templated DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA-templated DNA replication IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of ATAC complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of epsilon DNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of epsilon DNA polymerase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of epsilon DNA polymerase complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
DNA polymerase epsilon subunit 4
Names
DNA polymerase II subunit 4
DNA polymerase epsilon subunit p12
polymerase (DNA) epsilon 4, accessory subunit
polymerase (DNA-directed), epsilon 4, accessory subunit
NP_063949.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019896.4NP_063949.2  DNA polymerase epsilon subunit 4

    See identical proteins and their annotated locations for NP_063949.2

    Status: VALIDATED

    Source sequence(s)
    AC007400, BC031331, BU594966
    Consensus CDS
    CCDS1957.1
    UniProtKB/Swiss-Prot
    Q53TR2, Q9NR33
    Related
    ENSP00000420176.1, ENST00000483063.2
    Conserved Domains (1) summary
    COG5208
    Location:37112
    HAP5; CCAAT-binding factor, subunit C [Transcription]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    74958643..74970128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    74967499..74978982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)