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EIF5A2 eukaryotic translation initiation factor 5A2 [ Homo sapiens (human) ]

Gene ID: 56648, updated on 8-Mar-2025

Summary

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Official Symbol
EIF5A2provided by HGNC
Official Full Name
eukaryotic translation initiation factor 5A2provided by HGNC
Primary source
HGNC:HGNC:3301
See related
Ensembl:ENSG00000163577 MIM:605782; AllianceGenome:HGNC:3301
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EIF-5A2; eIF5AII
Summary
Predicted to enable translation elongation factor activity. Predicted to be involved in translational elongation. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Mar 2025]
Expression
Ubiquitous expression in brain (RPKM 2.4), testis (RPKM 2.3) and 25 other tissues See more
Orthologs
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Genomic context

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See EIF5A2 in Genome Data Viewer
Location:
3q26.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (170888418..170908637, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (173672753..173692976, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (170606207..170626426, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNY5 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20807 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:170587696-170588422 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:170588423-170589148 Neighboring gene ribosomal protein L22 like 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:170601523-170602103 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14888 Neighboring gene KLF7 pseudogene 1 Neighboring gene RNA, U1 small nuclear 70, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. Expression and amplification of eIF-5A2 in human epithelial ovarian tumors and overexpression of EIF-5A2 is a new independent predictor of outcome in patients with ovarian carcinoma. Yang GF, et al. Gynecol Oncol, 2009 Feb. PMID 19054548
  2. Knockdown of eukaryotic translation initiation factor 5A2 enhances the therapeutic efficiency of doxorubicin in hepatocellular carcinoma cells by triggering lethal autophagy. Tang Y, et al. Int J Oncol, 2020 Dec. PMID 33174013, Free PMC Article
  3. EIF5A2 is a novel chemoresistance gene in breast cancer. Liu Y, et al. Breast Cancer, 2015 Nov. PMID 24638963
  4. EIF5A2 enhances stemness of epithelial ovarian cancer cells via a E2F1/KLF4 axis. Wang K, et al. Stem Cell Res Ther, 2021 Mar 16. PMID 33726845, Free PMC Article
  5. Role of EIF5A2, a downstream target of Akt, in promoting melanoma cell invasion. Khosravi S, et al. Br J Cancer, 2014 Jan 21. PMID 24178756, Free PMC Article

See all (93) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MiR-5189-3p Suppresses cell Proliferation, Invasion and Migration Through Targeting EIF5A2 in Laryngeal Squamous Cell Carcinoma.
    Title: MiR-5189-3p Suppresses cell Proliferation, Invasion and Migration Through Targeting EIF5A2 in Laryngeal Squamous Cell Carcinoma.
  2. Long non-coding RNA RAD51-AS1 promotes the tumorigenesis of ovarian cancer by elevating EIF5A2 expression.
    Title: Long non-coding RNA RAD51-AS1 promotes the tumorigenesis of ovarian cancer by elevating EIF5A2 expression.
  3. microRNA-15a-5p suppresses hypoxia-induced tumor growth and chemoresistance in bladder cancer by binding to eIF5A2.
    Title: microRNA-15a-5p suppresses hypoxia-induced tumor growth and chemoresistance in bladder cancer by binding to eIF5A2.
  4. EIF5A2 Promotes Doxorubicin Resistance in Bladder Cancer Cells through the TGF-beta Signaling Pathway.
    Title: EIF5A2 Promotes Doxorubicin Resistance in Bladder Cancer Cells through the TGF-β Signaling Pathway.
  5. MicroRNA-577/EIF5A2 axis suppressed the proliferation of DDP-resistant nasopharyngeal carcinoma cells by blocking TGF-beta signaling pathway.
    Title: MicroRNA-577/EIF5A2 axis suppressed the proliferation of DDP-resistant nasopharyngeal carcinoma cells by blocking TGF-β signaling pathway.
  6. EIF5A2 specifically regulates the transcription of aging-related genes in human neuroblastoma cells.
    Title: EIF5A2 specifically regulates the transcription of aging-related genes in human neuroblastoma cells.
  7. EIF5A2 promotes proliferation and invasion of intrahepatic cholangiocarcinoma cells.
    Title: EIF5A2 promotes proliferation and invasion of intrahepatic cholangiocarcinoma cells.
  8. Eukaryotic Initiation Factor 5A2 Regulates Expression of Antiviral Genes.
    Title: Eukaryotic Initiation Factor 5A2 Regulates Expression of Antiviral Genes.
  9. HERC3 regulates epithelial-mesenchymal transition by directly ubiquitination degradation EIF5A2 and inhibits metastasis of colorectal cancer.
    Title: HERC3 regulates epithelial-mesenchymal transition by directly ubiquitination degradation EIF5A2 and inhibits metastasis of colorectal cancer.
  10. The deubiquitinating enzyme ATXN3 promotes the progression of anaplastic thyroid carcinoma by stabilizing EIF5A2.
    Title: The deubiquitinating enzyme ATXN3 promotes the progression of anaplastic thyroid carcinoma by stabilizing EIF5A2.
Submit: New GeneRIF Correction See all GeneRIFs (49)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
  
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of translational elongation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of translational termination IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 5A-2
Names
eIF-5A-2
eukaryotic initiation factor 5A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020390.6 → NP_065123.1  eukaryotic translation initiation factor 5A-2

    See identical proteins and their annotated locations for NP_065123.1

    Status: VALIDATED

    Source sequence(s)
    AY205261
    Consensus CDS
    CCDS3214.1
    UniProtKB/Swiss-Prot
    B2R4V5, Q9GZV4
    Related
    ENSP00000295822.2, ENST00000295822.7
    Conserved Domains (1) summary
    cl30809
    Location:1 → 150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    170888418..170908637 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    173672753..173692976 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9GZV4.3 GenPept UniProtKB/Swiss-Prot:Q9GZV4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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