Clec7a C-type lectin domain family 7, member a [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Clec7aprovided by MGI
Official Full Name: C-type lectin domain family 7, member aprovided by MGI
Primary source: MGI:MGI:1861431
See related: Ensembl:ENSMUSG00000079293 AllianceGenome:MGI:1861431
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BGR; beta-GR; Clecsf12
Summary: Predicted to enable (1->3)-beta-D-glucan binding activity and pattern recognition receptor activity. Predicted to be involved in several processes, including phagocytosis, recognition; positive regulation of cytokine production involved in inflammatory response; and response to fungus. Predicted to be active in cell surface. Is expressed in brain; gut; limb; musculature; and ventral grey horn. Human ortholog(s) of this gene implicated in aspergillosis and chronic mucocutaneous candidiasis. Orthologous to human CLEC7A (C-type lectin domain containing 7A). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Expression: Broad expression in lung adult (RPKM 2.7), bladder adult (RPKM 1.9) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6; 6 F3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (129438554..129449748, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (129461591..129472785, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Human Dectin-1 deficiency impairs macrophage-mediated defense against phaeohyphomycosis.
Title: Human Dectin-1 deficiency impairs macrophage-mediated defense against phaeohyphomycosis.
Repeated Stimulation of Toll-Like Receptor 2 and Dectin-1 Induces Chronic Pancreatitis in Mice Through the Participation of Acquired Immunity.
Title: Repeated Stimulation of Toll-Like Receptor 2 and Dectin-1 Induces Chronic Pancreatitis in Mice Through the Participation of Acquired Immunity.
Deletion of both Dectin-1 and Dectin-2 affects the bacterial but not fungal gut microbiota and susceptibility to colitis in mice.
Title: Deletion of both Dectin-1 and Dectin-2 affects the bacterial but not fungal gut microbiota and susceptibility to colitis in mice.
Adaptor protein 3BP2 regulates dectin-1-mediated cellular signalling to induce cytokine expression and NF-kappaB activation.
Title: Adaptor protein 3BP2 regulates dectin-1-mediated cellular signalling to induce cytokine expression and NF-κB activation.
Dectin-1 limits autoimmune neuroinflammation and promotes myeloid cell-astrocyte crosstalk via Card9-independent expression of Oncostatin M.
Title: Dectin-1 limits autoimmune neuroinflammation and promotes myeloid cell-astrocyte crosstalk via Card9-independent expression of Oncostatin M.
Ovalbumin-Induced Airway Inflammation Is Ameliorated in Dectin-1-Deficient Mice, in Which Pulmonary Regulatory T Cells Are Expanded through Modification of Intestinal Commensal Bacteria.
Title: Ovalbumin-Induced Airway Inflammation Is Ameliorated in Dectin-1-Deficient Mice, in Which Pulmonary Regulatory T Cells Are Expanded through Modification of Intestinal Commensal Bacteria.
Paracoccidioides brasiliensis activates mesenchymal stem cells through TLR2, TLR4, and Dectin-1.
Title: Paracoccidioides brasiliensis activates mesenchymal stem cells through TLR2, TLR4, and Dectin-1.
Molecular dynamics simulation of lentinan and its interaction with the innate receptor dectin-1.
Title: Molecular dynamics simulation of lentinan and its interaction with the innate receptor dectin-1.
Dectin-1 Stimulation of Hematopoietic Stem and Progenitor Cells Occurs In Vivo and Promotes Differentiation Toward Trained Macrophages via an Indirect Cell-Autonomous Mechanism.
Title: Dectin-1 Stimulation of Hematopoietic Stem and Progenitor Cells Occurs <i>In Vivo</i> and Promotes Differentiation Toward Trained Macrophages via an Indirect Cell-Autonomous Mechanism.
Intestinal Macrophages Balance Inflammatory Expression Profiles via Vitamin A and Dectin-1-Mediated Signaling.
Title: Intestinal Macrophages Balance Inflammatory Expression Profiles via Vitamin A and Dectin-1-Mediated Signaling.

Submit: New GeneRIF Correction See all GeneRIFs (120)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Clec7a gene: The Clec7a gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, and rat.
Orthologs from Annotation Pipeline: 167 organisms have orthologs with human gene Clec7a
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables (1->3)-beta-D-glucan binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables (1->3)-beta-D-glucan binding	IDA Inferred from Direct Assay more info	PubMed
enables (1->3)-beta-D-glucan immune receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables opsonin binding	IDA Inferred from Direct Assay more info	PubMed
enables pattern recognition receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables polysaccharide binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell surface pattern recognition receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to molecule of fungal origin	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in detection of fungus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in detection of molecule of fungal origin	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within detection of yeast	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within phagocytosis, engulfment	IDA Inferred from Direct Assay more info	PubMed
involved_in phagocytosis, recognition	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within phagocytosis, recognition	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of cytokine production involved in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of killing of cells of another organism	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of lymphocyte activation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of phagocytosis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within positive regulation of phagocytosis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of tumor necrosis factor production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of wound healing	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within response to molecule of fungal origin	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to yeast	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: C-type lectin domain family 7 member A

Names: C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12; C-type lectin superfamily member 12; DC-associated C-type lectin 1; beta-glucan receptor; dectin-1; dendritic cell-associated C-type lectin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001309637.2 → NP_001296566.1 C-type lectin domain family 7 member A isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

Source sequence(s)

AA240643, AC138620, BY750022

Consensus CDS

CCDS85170.1

UniProtKB/TrEMBL

V9GXI5

Related

ENSMUSP00000139167.2, ENSMUST00000184581.3

Conserved Domains (1) summary

cd03593
Location:74 → 197

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
NM_020008.4 → NP_064392.2 C-type lectin domain family 7 member A isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1, coding) represents the longer transcript and encodes the longer, functional protein (isoform 1).

Source sequence(s)

AA240643, AC138620, AF262985, BY750022

Conserved Domains (1) summary

cd03593
Location:119 → 242

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

RNA

NR_132130.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (1, non-coding) includes a premature stop codon and represents the non-functional allele, as in the C57BL/6 reference genome.

Source sequence(s)

AA240643, AC138620, BY750022

Related

ENSMUST00000195589.6