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Clec7a C-type lectin domain family 7, member a [ Mus musculus (house mouse) ]

Gene ID: 56644, updated on 29-Nov-2022

Summary

Official Symbol
Clec7aprovided by MGI
Official Full Name
C-type lectin domain family 7, member aprovided by MGI
Primary source
MGI:MGI:1861431
See related
Ensembl:ENSMUSG00000079293 AllianceGenome:MGI:1861431
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BGR; beta-GR; Clecsf12
Summary
Predicted to enable (1->3)-beta-D-glucan binding activity and pattern recognition receptor activity. Predicted to be involved in several processes, including phagocytosis, recognition; positive regulation of cytokine production involved in inflammatory response; and response to fungus. Predicted to be active in cell surface. Is expressed in brain; gut; limb; musculature; and ventral grey horn. Human ortholog(s) of this gene implicated in aspergillosis and chronic mucocutaneous candidiasis. Orthologous to human CLEC7A (C-type lectin domain containing 7A). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Expression
Broad expression in lung adult (RPKM 2.7), bladder adult (RPKM 1.9) and 16 other tissues See more
Orthologs
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Genomic context

See Clec7a in Genome Data Viewer
Location:
6; 6 F3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (129438554..129449748, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (129461591..129472785, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene C-type lectin domain family 12, member B Neighboring gene C-type lectin domain family 9, member a Neighboring gene C-type lectin domain family 1, member a Neighboring gene predicted gene, 45969 Neighboring gene oxidized low density lipoprotein (lectin-like) receptor 1 Neighboring gene transmembrane protein 52B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables (1->3)-beta-D-glucan binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables (1->3)-beta-D-glucan binding IDA
Inferred from Direct Assay
more info
PubMed 
enables (1->3)-beta-D-glucan immune receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables opsonin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables pattern recognition receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables polysaccharide binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell surface pattern recognition receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to molecule of fungal origin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in detection of fungus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in detection of molecule of fungal origin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within detection of yeast IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within phagocytosis, engulfment IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phagocytosis, recognition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within phagocytosis, recognition IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cytokine production involved in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of killing of cells of another organism IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of lymphocyte activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of phagocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of phagocytosis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of wound healing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within response to molecule of fungal origin IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to yeast IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
C-type lectin domain family 7 member A
Names
C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12
C-type lectin superfamily member 12
DC-associated C-type lectin 1
beta-glucan receptor
dectin-1
dendritic cell-associated C-type lectin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001309637.2NP_001296566.1  C-type lectin domain family 7 member A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AA240643, AC138620, BY750022
    Consensus CDS
    CCDS85170.1
    UniProtKB/TrEMBL
    V9GXI5
    Related
    ENSMUSP00000139167.2, ENSMUST00000184581.3
    Conserved Domains (1) summary
    cd03593
    Location:74197
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
  2. NM_020008.4NP_064392.2  C-type lectin domain family 7 member A isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, coding) represents the longer transcript and encodes the longer, functional protein (isoform 1).
    Source sequence(s)
    AA240643, AC138620, AF262985, BY750022
    Conserved Domains (1) summary
    cd03593
    Location:119242
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

RNA

  1. NR_132130.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, non-coding) includes a premature stop codon and represents the non-functional allele, as in the C57BL/6 reference genome.
    Source sequence(s)
    AA240643, AC138620, BY750022
    Related
    ENSMUST00000195589.6

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    129438554..129449748 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)